MnO2 Decorated Metal‐Organic Framework‐Based Hydrogel Relieving Tumor Hypoxia for Enhanced Photodynamic Therapy DOI
Yifan Li,

Jian Wang,

Hanrong Li

et al.

Macromolecular Rapid Communications, Journal Year: 2023, Volume and Issue: 44(19)

Published: July 5, 2023

Photodynamic therapy (PDT) has emerged as a promising cancer treatment modality; however, its therapeutic efficacy is greatly limited by tumor hypoxia. In this study, metal-organic framework (MOF)-based hydrogel (MOF Gel) system that synergistically combines PDT with the supply of oxygen designed. Porphyrin-based Zr-MOF nanoparticles are synthesized photosensitizer. MnO2 decorated onto surface MOF, which can effectively convert H₂O₂ into oxygen. Simultaneously, incorporation -decorated MOF (MnP NPs) chitosan serves to enhance stability and retention at site. The results show integrated approach significantly improves inhibition efficiency relieving hypoxia enhancing PDT. Overall, findings underscore potential for employing nano-MOF-based systems agents therapy, thus advancing application multifunctional MOFs in treatment.

Language: Английский

NIR light-activated nanocomposites combat biofilm formation and enhance antibacterial efficacy for improved wound healing DOI Creative Commons

I. Ullah,

Shahin Shah Khan, Waqar Ahmad

et al.

Communications Chemistry, Journal Year: 2024, Volume and Issue: 7(1)

Published: June 8, 2024

Abstract Nanoparticle-based therapies are emerging as a pivotal frontier in biomedical research, showing their potential combating infections and facilitating wound recovery. Herein, selenium-tellurium dopped copper oxide nanoparticles (SeTe-CuO NPs) with dual photodynamic photothermal properties were synthesized, presenting an efficient strategy for bacterial infections. In vitro evaluations revealed robust antibacterial activity of SeTe-CuO NPs, achieving up to 99% eradication bacteria significant biofilm inhibition upon near-infrared (NIR) irradiation. Moreover, vivo studies demonstrated accelerated closure treatment NIR-activated demonstrating efficacy promoting healing. Furthermore, NPs exhibited rapid clearance within wounds, offering promising solution care. Overall, this versatile platform holds great promise multidrug-resistant advancing therapeutic interventions management.

Language: Английский

Citations

4
Novel platinum therapeutics induce rapid cancer cell death through triggering intracellular ROS storm DOI
Yongbin Liu,

Dongfang Yu,

Xueying Ge

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122835 - 122835

Published: Sept. 12, 2024

Language: Английский

Citations

4
Antitumor Cream: Transdermal Hydrogel Containing Liposome‐Encapsulated Ruthenium Complex for Infrared‐Controlled Multimodal Synergistic Therapy DOI Open Access
Yufei Yan,

Xue‐Lian Li,

Li‐Zhen Zeng

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Abstract A transdermal drug delivery cream, which is non‐invasive and painless, containing a liposome‐encapsulated Ru(II) complex ( LipoRu ) created for the treatment of skin cancer. This formulation capitalizes on synergistic antitumor effects two‐photon excited photodynamic therapy (PDT), photothermal (PTT), chemotherapy. exhibits effective tumor accumulation, efficient cellular uptake, pH‐sensitive infrared‐accelerated release, dual localization to nucleus mitochondria. The released complexes within cells exert multiple mechanisms, such as DNA topoisomerase RNA polymerase inhibition, Type I II PDT, PTT, photodamage, apoptosis ferroptosis induction. biodistribution therapeutic efficacy in vivo are systematically compared via three distinct administration routes: intratumoral injection, intravenous through topical cream application. positive fabricated here subcutaneous tumor‐bearing mice offer optimistic potential painless both early‐stage advanced cancers, well superficially located solid tumors.

Language: Английский

Citations

4
Addressing the in vivo delivery of nucleic-acid nanostructure therapeutics DOI

Shana Alexander,

Mohammadamir G. Moghadam,

Meghan Rothenbroker

et al.

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 199, P. 114898 - 114898

Published: May 23, 2023

Language: Английский

Citations

10
MnO2 Decorated Metal‐Organic Framework‐Based Hydrogel Relieving Tumor Hypoxia for Enhanced Photodynamic Therapy DOI
Yifan Li,

Jian Wang,

Hanrong Li

et al.

Macromolecular Rapid Communications, Journal Year: 2023, Volume and Issue: 44(19)

Published: July 5, 2023

Photodynamic therapy (PDT) has emerged as a promising cancer treatment modality; however, its therapeutic efficacy is greatly limited by tumor hypoxia. In this study, metal-organic framework (MOF)-based hydrogel (MOF Gel) system that synergistically combines PDT with the supply of oxygen designed. Porphyrin-based Zr-MOF nanoparticles are synthesized photosensitizer. MnO2 decorated onto surface MOF, which can effectively convert H₂O₂ into oxygen. Simultaneously, incorporation -decorated MOF (MnP NPs) chitosan serves to enhance stability and retention at site. The results show integrated approach significantly improves inhibition efficiency relieving hypoxia enhancing PDT. Overall, findings underscore potential for employing nano-MOF-based systems agents therapy, thus advancing application multifunctional MOFs in treatment.

Language: Английский

Citations

10