Injectable Self‐Expanding/Self‐Propelling Hydrogel Adhesive with Procoagulant Activity and Rapid Gelation for Lethal Massive Hemorrhage Management

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(15)

Published: Nov. 16, 2023

Developing hydrogels that can quickly reach deep bleeding sites, adhere to wounds, and expand stop lethal and/or noncompressible in civil battlefield environments remains a challenge. Herein, an injectable, antibacterial, self-expanding, self-propelling hydrogel bioadhesive with procoagulant activity rapid gelation is reported. This combines spontaneous gas foaming Schiff base crosslinking for massive hemorrhage. Hydrogels have expansion rate, high self-expanding ratio, excellent antibacterial activity, antioxidant efficiency, tissue adhesion capacity. In addition, good cytocompatibility, ability, higher blood cell/platelet than commercial combat gauze gelatin sponge. The optimized (OD-C/QGQL-A30) exhibits better hemostatic ability sponge rat liver femoral artery models, rabbit volumetric loss models with/without anticoagulant, kidney incision site not visible. Especially, OD-C/QGQL-A30 rapidly stops the bleedings from pelvic area of rabbit, swine subclavian vein transection. Furthermore, has biodegradability biocompatibility, accelerates Methicillin-resistant S. aureus (MRSA)-infected skin wound healing. opens up new avenue develop hemostats bleeding, abdominal organ coagulation lesions.

Language: Английский

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Gelable and Adhesive Powder for Lethal Non‐Compressible Hemorrhage Control

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(46)

Published: Aug. 4, 2023

Abstract Hemostatic powders are widely used in clinical and emergency situations but often exhibit low wet adhesion, cytotoxicity concerns, do not work well for lethal non‐compressible hemorrhage. Here a new kind of gelable adhesive powder (GAP) is developed, which integrates chitosan microspheres (CM), tetra‐armed poly(ethylene glycol) amine (Tetra‐PEG‐NH 2 ), succinimidyl succinate (Tetra‐PEG‐SS). Upon application to the wound site, macroporous CM can rapidly absorb interfacial liquids, meanwhile, hydrated GAP turns into hydrogel (crosslinking between Tetra‐PEG‐SS CM/Tetra‐PEG‐NH ) with stable robust adhesion tissue though covalent bonding. The vitro vivo results suggest that optimized formulation exhibits strong adhesive, high burst pressure, enhanced blood clotting ability, as excellent biocompatibility on‐demand removal properties. A significantly improved hemostatic efficacy demonstrated rat liver, spleen, femoral artery injury models compared CM, commercial fibrin glue, Yunnan Baiyao (YB). also halt severe bleeding from pig visceral organs. Overall, proposed has many advantages including good biocompatibility, rapid effective hemostasis, cost, ease use, making it promising hemostat hemorrhage control.

Language: Английский

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The marriage of immunomodulatory, angiogenic, and osteogenic capabilities in a piezoelectric hydrogel tissue engineering scaffold for military medicine

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: July 31, 2023

Most bone-related injuries to grassroots troops are caused by training or accidental injuries. To establish preventive measures reduce all kinds of trauma and improve the combat effectiveness troops, it is imperative develop new strategies scaffolds promote bone regeneration.

Language: Английский

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Efficient recovery of highly viscous crude oil spill by superhydrophobic ocean biomass-based aerogel assisted with solar energy

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 467, P. 143532 - 143532

Published: May 15, 2023

Language: Английский

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Recent advances of chitosan as a hemostatic material: Hemostatic mechanism, material design and prospective application

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 327, P. 121673 - 121673

Published: Dec. 9, 2023

Language: Английский

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Progress in chitin/chitosan and their derivatives for biomedical applications: Where we stand

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 343, P. 122233 - 122233

Published: May 4, 2024

Language: Английский

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Anisotropic Shape‐Memory Cryogel with Oriented Macroporous Channel for Hemorrhage Control and Tissue Generation

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Injectable shape‐memory materials represent a promising solution for managing severe bleeding from deep, inaccessible wounds. However, many existing expandable hemostats consist of randomly porous networks and often exhibit inadequate liquid absorption, non‐degradability, potential cytotoxicity, which limits their effectiveness in hemostasis wound repair. To overcome these challenges, this study introduces an anisotropic hemostatic cryogel, SALC, featuring oriented macroporous channels made biocompatible polymers (poly(ethylene glycol), gelatin, lignin) through simple one‐step cryo‐structuration process. This structural alignment provides the cryogel with low water flow resistance, efficient fluid transport, rapid shape recovery. SALC demonstrates superior adsorption retention, vitro tamponade sealing, pro‐coagulant properties compared to commercial gelatin sponges XSTAT, along favorable biocompatibility biodegradability. The efficacy surpasses clinically used counterparts rat models liver perforation femoral artery transection. Remarkably, achieves effective porcine hepatic, artery, cardiac injuries. Additionally, supports tissue regeneration by promoting cell migration angiogenesis while mitigating inflammatory responses. is also lightweight easy carry implement. Overall, shows clinical applications treating hemorrhages improving healing.

Language: Английский

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A Strong and Water‐Retaining Biomass Adhesive Inspired by Tofu

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 9, 2025

Abstract The poor mechanical strength and low water retention of biomass adhesives present significant challenges when substituting petrochemical in practical applications. Inspired by the colloidal gel structure Tofu, development a high‐performance protein‐based adhesive derived from soybean meal (SM) oxidized glucose oxidase (GOx) calcium sulfate oligomer (CSO) is reported. catalytic oxidation sugars SM GOx produces active carboxyl groups, increasing sites for bridge (sugar‐protein) formation CSO. Concurrently, disrupts internal electrostatic equilibrium SM, promoting an acid‐induced gel‐like network structure. This Tofu‐like structures can effectively minimize evaporation significantly enhance interfacial adhesion. Plywood bonded with modified demonstrates 129% increase wet compared to unmodified counterparts. Additionally, loss rate reduced 30.66% at 30 minutes, while maintaining 70.37% its initial strength. enzymatically mediated organic–inorganic hybrid represents promising strategy future sustainable adhesives.

Language: Английский

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Cellulose nanofibers embedded chitosan/tannin hydrogel with high antibacterial activity and hemostatic ability for drug-resistant bacterial infected wound healing

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 329, P. 121687 - 121687

Published: Dec. 12, 2023

Language: Английский

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Quaternized chitosan/oxidized bacterial cellulose cryogels with shape recovery for noncompressible hemorrhage and wound healing

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 327, P. 121679 - 121679

Published: Dec. 13, 2023

Language: Английский

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