Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 1, 2024
Abstract
Hepatocellular
carcinoma
(HCC)
is
among
the
most
common
malignancies
worldwide
and
characterized
by
high
rates
of
morbidity
mortality,
posing
a
serious
threat
to
human
health.
Interventional
embolization
therapy
main
treatment
against
middle-
late-stage
liver
cancer,
but
its
efficacy
limited
performance
embolism,
hence
new
embolic
materials
have
provided
hope
inoperable
patients.
Especially,
hydrogel
with
strength,
appropriate
viscosity,
reliable
security
multifunctionality
are
widely
used
as
materials,
can
improve
interventional
therapy.
In
this
review,
we
described
status
research
on
hydrogels
challenges
in
field
HCC
First,
various
preparation
methods
through
different
cross-linking
introduced,
then
functions
related
summarized,
including
therapies,
imaging
techniques,
vitro
3D
models,
shortcomings
prospects
proposed
applications
discussed
relation
HCC.
We
that
review
informative
for
readers
interested
multifunctional
will
help
researchers
develop
more
novel
Graphical
Chemical Engineering Journal,
Journal Year:
2024,
Volume and Issue:
487, P. 150403 - 150403
Published: March 16, 2024
Hydrogels
have
emerged
in
various
biomedical
applications,
including
tissue
engineering
and
medical
devices,
due
to
their
ability
imitate
the
natural
extracellular
matrix
(ECM)
of
tissues.
However,
conventional
static
hydrogels
lack
dynamically
respond
changes
surroundings
withstand
robust
biophysical
microenvironment
trigger
on-demand
functionality
such
as
drug
release
mechanical
change.
In
contrast,
multifunctional
dynamic
can
adapt
external
stimuli
drawn
great
attention
recent
studies.
It
is
realized
that
integration
nanomaterials
into
provides
numerous
functionalities
for
a
variety
applications
cannot
be
achieved
by
hydrogels.
This
review
article
comprehensive
overview
advances
designing
fabricating
applications.
We
describe
different
types
based
on
breakable
reversible
covalent
bonds
well
noncovalent
interactions.
These
mechanisms
are
described
detail
useful
reference
crosslinking
strategies
strongly
influence
properties
also
discuss
use
potential
benefits.
further
explores
nanocomposite
hydrogels,
delivery,
engineering,
bioadhesives,
wound
healing,
cancer
treatment,
mechanistic
study,
multiple-scale
Finally,
we
challenges
future
perspectives
field
diverse
technologies.
Gels,
Journal Year:
2025,
Volume and Issue:
11(1), P. 31 - 31
Published: Jan. 2, 2025
Researchers
have
been
investigating
the
physical
and
morphological
properties
of
biodegradable
polymer
copolymer
films,
blending
them
with
other
chemicals
to
solve
challenges
in
medical,
industrial,
eco-environmental
fields.
The
present
study
introduces
a
novel,
straightforward
method
for
preparing
hydrogels
based
on
polyvinyl
alcohol
(PVA)
pyrrolidone
(PVP)
medical
applications.
resulting
PVA/PVP-based
hydrogel
uniquely
combines
water
absorbency,
biocompatibility,
biodegradability
composite.
For
hygiene
products
uses,
such
as
wound
healing,
hydrogen
peroxide
(HP)
was
encapsulated
PVA/PVP
controlled
release
application.
Incorporating
PVP
into
PVA
significantly
enhances
absorbency
improves
mechanical
properties.
However,
mitigate
disadvantage
high
which
could
result
undesired
early
dissolution,
efforts
were
made
increase
resistance
characteristics
these
using
freeze-thaw
(F/T)
cycles
chemical
crosslinking
chains
trisodium
trimetaphosphate
(STMP).
serve
environmentally
friendly
bio-based
blends,
broadening
their
applications
industrial
products.
structural
characterized
Fourier
transform
infrared
spectroscopy
(FTIR),
environmental
scanning
electron
microscope
analysis
(E-SEM),
water-swelling
tests.
HP
rate
evaluated
through
kinetic
experiments
ex
vivo
skin
model.
antibacterial
activity
films
examined
four
medically
relevant
bacteria:
Staphylococcus
aureus,
Enterococcus
faecalis,
Escherichia
coli,
Pseudomonas
aeruginosa,
an
adapted
disk
diffusion
assay.
Using
this
assay,
we
also
effect
over
course
days,
demonstrating
from
hydrogels.
These
findings
support
further
investigation
systems
improved
wound-healing
outcomes.
The
severe
side
effects
of
systemic
chemotherapy
for
cervical
cancer
encourage
the
use
topical
intravaginal
drug
delivery
systems.
5-fluorouracil,
5-FU,
is
an
anticancer
accepted
in
clinical
therapy
colorectal,
gastric,
and
hepatocellular
carcinoma.
However,
it
shows
low
activity
against
cells
(HeLa)
thus
requires
usage
additional
drugs
to
support
therapy,
which
associated
with
effects.
We
report
on
polyglycidol/polyacrylamide-based
hydrogel
carrier
providing
effective
monotherapy
cells,
HeLa
along
a
neutral
effect
normal
HMEC-1.
hyperbranched
polyglycidol
modified
aryl
groups,
i.e.,
phenylurethane,
1,4-biphenylurethane,
benzoyl
ester,
respectively,
enhance
solubility
5-FU
aqueous
medium
ensured
drug's
efficacy
selectivity
Hela
after
48
h
at
dose.
Crucially,
cross-linking
drug-loaded
aryl-enriched
acrylamide
copolymer
bearing
2-acrylamidephenylboronic
acid
induced
anticervical
reducing
time
required
complete
cell
death
24
h.
An
vitro
study
showed
that
boronic
moieties
are
responsible
promotion
5-FU.
Reported
hydrogels'
structure
based
reversibly
cross-linked
HbPGLs
provides
self-healing
properties
network
crucial
formation
continuous
layer
formulation
ensuring
afflicted
area
covered
tissue.
Among
tested
hydrogels,
system
constructed
from
HbPGL
linear
constitutional
units
were
ester
or
phenylurethane
approximately
45
mol
%
highest
permeability
through
STRAT-M
model
membrane.
This
demonstrates
direction
synthetic
design
assuring
safe
avoiding
typical
combinatory
therapies.
Precision medicine and engineering.,
Journal Year:
2024,
Volume and Issue:
1(1), P. 100001 - 100001
Published: July 28, 2024
Stimulus-responsive
hydrogels
can
undergo
controllable
shape
deformation
and
exhibit
sol-gel
transition
behavior
under
stimulus
signals
such
as
pH,
reactive
oxygen
species
(ROS),
heat,
light.
Polysaccharides
have
become
ideal
candidates
for
constructing
stimulus-responsive
due
to
their
biocompatibility
biodegradability.
The
diversity
of
molecular
weights
functional
groups
polysaccharides
allows
them
self-assemble
or
cooperate
with
other
materials
obtain
through
physical
chemical
crosslinking.
Bioactive
ingredients
nanomaterials
be
conveniently
encapsulated
in
the
hydrogel
matrix
meet
various
requirements.
polysaccharide-based
are
widely
used
biomedical
field,
especially
fields
drug
delivery,
tissue
engineering,
biosensors,
imaging.
In
this
review,
design
strategies
recent
research
advances
stimuli-responsive
summarized.
Future
challenges
also
presented,
review
will
guide
study
polysaccharide
hydrogels.
