ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 2, 2024
Between
2015
and
2017,
90%
of
Chinese
adults
were
reported
to
have
periodontitis
varying
degrees,
highlighting
the
importance
novel,
inexpensive,
affordable
treatments
for
public.
The
fact
that
more
pathogens
are
becoming
resistant
antibiotics
further
highlights
this
prevalence.
This
article
addresses
a
novel
micromotor
capable
generating
reactive
oxygen
species,
as
proven
by
Fenton-like
reaction.
Such
reactions
allow
targeting
Gram-negative
bacteria
such
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(21), P. 5000 - 5023
Published: Jan. 1, 2024
Currently,
the
rapid
spread
of
multidrug-resistant
bacteria
derived
from
indiscriminate
use
traditional
antibiotics
poses
a
significant
threat
to
public
health
worldwide.
Moreover,
established
bacterial
biofilms
are
extremely
difficult
eradicate
because
their
high
tolerance
antimicrobial
agents
and
extraordinary
resistance
phagocytosis.
Hence,
it
is
universal
significance
develop
novel
robust
efficient
antibacterial
strategies
combat
infections.
Micro/nanomotors
exhibit
many
intriguing
properties,
including
enhanced
mass
transfer
micro-mixing
resulting
locomotion,
intrinsic
capabilities,
active
cargo
delivery,
targeted
treatment
with
precise
micromanipulation,
which
facilitate
delivery
antimicrobials
infected
sites
deep
permeation
into
for
fast
inactivation.
Thus,
ideal
activity
micro/nanorobots
makes
them
desirable
alternatives
treatments
has
aroused
extensive
interest
in
recent
years.
In
this
review,
advancements
micro/nanomotors
briefly
summarized,
focusing
on
synthetic
methods,
propulsion
mechanism,
versatile
applications.
Finally,
some
personal
insights
current
challenges
possible
future
directions
translate
proof-of-concept
research
clinic
application
proposed.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
Abstract
Thrombotic
cardiovascular
diseases
remain
the
leading
cause
of
mortality
worldwide.
However,
current
thrombolytic
therapeutics
suffer
from
limited
efficacy
and
a
high
risk
severe
bleeding.
Here,
phosphatidylcholine
liposome
accelerated
platinum
nanomachine
(PLANE)
for
thrombus
mechanotherapy
is
designed,
constructed
by
encapsulating
nanomotors
within
isotropic,
lubricating
(PC)
liposomes.
The
precisely
engineered
PLANE
exhibits
superior
lubricity
linear
motion.
Under
laser
irradiation
hydrogen
peroxide
treatment,
PLANEs
achieve
significantly
higher
velocities
than
conventional
nanomotors,
facilitating
deep
penetration
into
thrombi.
Further
functionalization
with
thrombus‐targeting
peptides
enables
cPLANEs
to
selectively
accumulate
at
thrombotic
sites
in
vivo,
demonstrating
excellent
efficacy.
This
work
presents
novel
surface
modification
strategy
optimizing
motion
behavior
offering
promising
non‐pharmaceutic
approach
disease
treatment.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 30, 2025
Abstract
Efficient,
adaptive,
and
precise
operation
in
complex
microenvironments
requires
the
careful
design
manufacturing
of
tiny
machines
that
provide
optical
signaling,
flexible
navigation,
remote
control.
Here,
chemical/photoactivated
Au
microswimmers
capable
multi‐color
light
signaling
is
presented,
which
exhibit
distinct
swimming
behaviors
depending
on
fuel
availability
illumination
conditions.
The
system's
functionality
further
enhanced
by
incorporating
a
second
engine
Fe
2
O
3
,
enabling
fast‐switchable
propulsion
directional
Moreover,
these
retain
their
while
being
remotely
controlled
magnetic
field
illumination.
Under
rotational
field,
an
intriguing
phenomenon
orbital
rotation
around
motile
center
observed,
occurs
when
fluctuations
angular
displacement
are
suppressed.
This
behavior
corroborated
Brownian
dynamics
simulations.
approach
integrates
photoemission,
reversal,
control
into
single
system,
providing
strong
foundation
for
developing
orthogonal
micromachines
real‐time
imaging
targeting.
Advanced Materials Technologies,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 16, 2024
Abstract
Biomimetic
and
biohybrid
micro/nano‐structures
involve
the
replication
creation
of
technologies,
structures,
materials
based
on
biological
systems
at
micrometer
nanometer
scale.
These
strategies
harness
natural
principles
to
develop
innovative
treatment
methods
advanced
microstructure
devices
for
noninvasive
therapies.
In
this
study,
a
detailed
overview
fabrication
processes,
magnetically
assisted
locomotive
techniques,
potential
applications
biomimetic
micro/nano‐machines
are
presented.
The
latest
advancements
in
actuated
such
as
annelid‐worm‐like
microswimmers,
jellyfish‐shaped
microparticles,
fish‐shaped
walnut‐shaped
micromotors
explored.
Additionally,
magnetic
systems,
including
sunflower
seed‐based
micro‐perforators,
nanomotors
extracted
from
bamboo
stem,
sperm
cell‐based
micromotors,
bacteria‐based
robots,
scaffold‐based
microrobots,
DNA‐based
microalgae‐based
red
blood
microswimmers
also
examined.
A
thorough
investigation
behavior
these
Newtonian
fluids,
featuring
cork‐screw
motion,
undulatory
surface
wrinkling
traveling
wave‐like
ciliary
stroke
motion
is
discussed.
Furthermore,
unprecedented
developed
using
minuscule
cervical
cancer
tetrapod
hybrid
tissue
regeneration
silk
fibroin
protein‐based
microscale
scaffolds,
doxorubicin
drug
delivery
mushroom‐based
microrobots
extensively
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Abstract
Biological
enzyme‐functionalized
antibacterial
nanoparticles,
which
can
degrade
biofilm
and
kill
bacteria
under
mild
reaction
conditions,
have
attracted
much
attention
for
the
elimination
of
deep‐seated
bacterial
infections.
However,
poor
diffusion
penetration
capabilities
recently
developed
biological
nanoparticles
in
severely
impair
eradication
efficacy
bacteria.
Herein,
a
photothermal‐driven
nanomotor
(denoted
as
APPNM)
is
enhancing
drug‐resistant
biofilms
The
contained
pot‐like
polydopamine
(PDA)
nanostructure
its
outer
surface
chemically
immobilized
with
layer
α‐amylases.
Under
exposure
to
808
nm
near‐infrared
(NIR)
laser
irradiation,
self‐propelled
nanomotors,
integrating
α‐amylases
destroy
compact
structure
biofilms,
penetrate
deeply
into
effectively
eliminate
them.
Subsequently,
they
accumulate
on
using
inherent
bio‐adhesion
property
PDA,
thereby
completely
eradicating
by
photothermal
effect.
These
synergistic
effects
enable
them
exhibit
superior
antibiofilm
produce
remarkable
therapeutic
accelerated
wound
healing
vivo.
With
excellent
biocompatibility,
as‐developed
nanomotors
great
potential
be
applied
treating
biofilm‐related
Bacterial
infections
pose
a
significant
global
health
challenge
aggravated
by
the
rise
of
antimicrobial
resistance
(AMR).
Among
obstacles
preventing
effective
treatment
are
biological
barriers
(BBs)
within
body
such
as
mucus
layer.
These
BBs
trap
antimicrobials,
necessitating
higher
doses
and
ultimately
accelerating
AMR.
Addressing
this
issue
requires
innovative
therapeutic
strategies
capable
bypassing
to
deliver
drugs
more
effectively.
Here,
we
present
nanomotors
(NMs)
based
on
hyaluronic
acid
(HA)-
urease-nanogels
(NGs)
solution
navigate
effectively
in
viscous
media
catalyzing
decomposition
urea
into
ammonium
carbon
dioxide.
HA-based
(HA-NMs)
were
loaded
with
chloramphenicol
(CHL)
antibiotic
demonstrated
superior
activity
against
Escherichia
coli(E.
coli)
compared
mesoporous
silica
NMs
(MSNP-NMs),
reference
field
NMs.
Moreover,
using
an
vitro
transwell
model
evaluated
ability
HA-NMs
penetrate
mucin
barriers,
reducing
E.
coli
proliferation,
whereas
free
did
not
reduce
bacteria
proliferation.
The
optical
density
reduction
at
24
h
was
over
ten
times
greater
than
CHL.
organic-based
enzyme-powered
represent
advancement
drug
delivery,
offering
promising
approach
combat
AMR
while
addressing
challenges
crossing
complex
BBs.
