Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162628 - 162628
Published: April 1, 2025
Language: Английский
Exploration, Journal Year: 2024, Volume and Issue: unknown
Published: May 30, 2024
Cell behavior is intricately intertwined with the in vivo microenvironment and endogenous pathways. The ability to guide cellular toward specific goals can be achieved by external stimuli, notably electricity, light, ultrasound, magnetism, simultaneously harnessed through biomaterial-mediated responses. These triggers become focal points within body due interactions biomaterials, facilitating a range of pathways: electrical signal transmission, biochemical cues, drug release, cell loading, modulation mechanical stress. Stimulus-responsive biomaterials hold immense potential biomedical research, establishing themselves as pivotal point interdisciplinary pursuits. This comprehensive review systematically elucidates prevalent physical stimuli their corresponding biomaterial response mechanisms. Moreover, it delves deeply into application domain biomedicine. A balanced assessment distinct stimulation techniques provided, along discussion merits limitations. aims shed light on future trajectory stimulus-responsive disease treatment outline prospects for development. poised spark novel concepts advancing intelligent, biomaterials.
Language: Английский
Citations
19
Ultrasonics Sonochemistry, Journal Year: 2023, Volume and Issue: 100, P. 106617 - 106617
Published: Sept. 23, 2023
The rapid spread and uncontrollable evolution of antibiotic-resistant bacteria have already become urgent global to treat bacterial infections. Sonodynamic therapy (SDT), a noninvasive effective therapeutic strategy, has broadened the way toward dealing with biofilms, which base on ultrasound (US) sonosensitizer. Sonosensitizer, based small organic molecules or inorganic nanoparticles, is essential SDT process. Thus, it meaningful design sonosensitizer-loaded nanoplatform synthesize an efficient effect. In this review, we initially summarize probable SDT-based antibacterial mechanisms systematically discuss current advancement in different (including for small-molecule sonosensitizer delivery as sonosensitizer) infection therapy. addition, biomedical applications SDT-involved multifunctional nanoplatforms are also discussed. We believe innovative would highly next-generation tool combating infection.
Language: Английский
Citations
40
Nanomaterials, Journal Year: 2023, Volume and Issue: 13(15), P. 2269 - 2269
Published: Aug. 7, 2023
Photothermal therapy has the advantages of non-invasiveness, low toxicity, simple operation, a broad spectrum antibacterial ability, and non-proneness to developing drug resistance, which provide it with irreplaceable superiority in fighting against microbial infection. The effect photothermal is closely related choice agent. Conjugated nanomaterials are potential candidates for agents because their easy modification, excellent conversion efficiency, good photostability, biodegradability. In this paper, application based on conjugated antimicrobial treatment reviewed, including small molecules, oligomers, polymers, pseudo-conjugated polymers. At same time, combination (PTT) photodynamic (PDT) briefly introduced. Finally, research status, limitations, prospects using as discussed.
Language: Английский
Citations
25
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216205 - 216205
Published: Sept. 11, 2024
Language: Английский
Citations
18
Advanced Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 23, 2024
Low-intensity ultrasound-mediated sonodynamic therapy (SDT), which, by design, integrates sonosensitizers and molecular oxygen to generate therapeutic substances (e.g., toxic hydroxyl radicals, superoxide anions, or singlet oxygen) at disease sites, has shown enormous potential for the effective treatment of a variety diseases. Nanoscale play crucial role in SDT process because their structural, compositional, physicochemical, biological characteristics are key determinants efficacy. In particular, advances materials science nanotechnology have invigorated series optimization strategies augmenting efficacy nanosonosensitizers. This comprehensive review systematically summarizes, discusses, highlights state-of-the-art studies on current achievements nanosonosensitizer enhanced treatment, with an emphasis general design principles nanosonosensitizers strategies, mainly including organic inorganic Additionally, recent advancements optimized applications aimed treating various diseases, such as cancer, bacterial infections, atherosclerosis, autoimmune clarified detail. Furthermore, effects improved versatile thoroughly discussed. The concludes highlighting challenges future opportunities this rapidly evolving research field expedite its practical clinical translation application.
Language: Английский
Citations
16
Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 374 - 383
Published: May 10, 2024
Implant-related osteomyelitis is a formidable hurdle in the clinical setting and characterized by inflammation, infection, consequential bone destruction. Therefore, effective reactive oxygen species (ROS) scavenging, bacterial killing, subsequent tissue repair are urgently needed for treatment of difficult-to-heal osteomyelitis. Herein, we utilized eddy-thermal effect magnesium (Mg) implants under an alternating magnetic field (AMF) controlled release H
Language: Английский
Citations
15
Trends in Immunology, Journal Year: 2024, Volume and Issue: 45(7), P. 549 - 563
Published: June 23, 2024
Language: Английский
Citations
11
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 508, P. 160962 - 160962
Published: Feb. 25, 2025
Language: Английский
Citations
2
Advanced Materials, Journal Year: 2023, Volume and Issue: 36(9)
Published: Nov. 7, 2023
Sono-photodynamic therapy is hindered by the limited tissue penetration depth of external light source and quick recombination electron-hole owing to random movement charge carriers. In this study, orthorhombic ZnSnO
Language: Английский
Citations
24
National Science Review, Journal Year: 2024, Volume and Issue: 11(4)
Published: Feb. 5, 2024
ABSTRACT Tirapazamine (TPZ) has been approved for multiple clinical trials relying on its excellent anticancer potential. However, as a typical hypoxia-activated prodrug (HAP), TPZ did not exhibit survival advantages in Phase III when used combination therapy due to the insufficient hypoxia levels patients’ tumors. In this study, improve therapeutic effects of TPZ, we first introduced urea synthesize series urea-containing derivatives TPZ. All showed increased hypoxic cytotoxicity (9.51–30.85-fold) compared with while maintaining selectivity. TPZP, one these derivatives, 20-fold higher than similar ratio. To highly efficiently deliver TPZP tumors and reduce side healthy tissues, further prepared into nanodrug fibrin-targeting ability: FT11-TPZP-NPs. CA4-NPs, vascular disrupting agent, was increase fibrin level within exacerbate tumor hypoxia. By being combined FT11-TPZP-NPs can accumulate hypoxia-aggravated activate sufficiently kill cells. After single-dose treatment, + CA4-NPs high inhibition rate 98.1% against CT26 models an initial volume ∼480 mm3 four out six were completely eliminated; it thereby exerted significant antitumor effect. This study provides new strategy improving effect other HAPs therapy.
Language: Английский
Citations
9