Chemistry - An Asian Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 8, 2025
Abstract
Bacterial
infections
remain
a
significant
and
escalating
threat
to
global
health,
exacerbated
by
multidrug‐resistant
strains
that
undermine
the
efficacy
of
conventional
antibiotics.
This
pressing
issue
underscores
urgent
need
for
development
new
antimicrobial
materials.
Among
these,
molecular‐based
crystalline
porous
materials,
such
as
metal–organic
frameworks
(MOFs),
covalent
organic
(COFs),
hydrogen‐bonded
(HOFs),
supramolecular
assembly
(SAFs),
have
emerged
promising
class
antibacterial
agents.
These
materials
exhibit
well‐defined
crystallinity
tunable
structures,
offering
exceptional
versatility
applications.
Notably,
their
high
surface
area,
adjustable
pore
size,
potential
functionalization
enable
efficient
loading
controlled
release
agents,
including
metal
ions
molecules.
review
provides
comprehensive
analysis
recent
advancements
in
this
field,
highlighting
design
strategies,
structural
diversity,
mechanisms,
Finally,
we
discuss
current
challenges
outline
future
opportunities
practical
deployment
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1829 - 1829
Published: June 26, 2023
Nanofiber
scaffolds
have
emerged
as
a
revolutionary
drug
delivery
platform
for
promoting
wound
healing,
due
to
their
unique
properties,
including
high
surface
area,
interconnected
porosity,
excellent
breathability,
and
moisture
absorption,
well
spatial
structure
which
mimics
the
extracellular
matrix.
However,
use
of
nanofibers
achieve
controlled
loading
release
still
presents
many
challenges,
with
ongoing
research
exploring
how
load
drugs
onto
nanofiber
without
loss
activity
control
in
specific
spatiotemporal
manner.
This
comprehensive
study
systematically
reviews
applications
recent
advances
related
drug-laden
skin-wound
management.
First,
we
introduce
commonly
used
methods
preparation,
electrostatic
spinning,
sol-gel,
molecular
self-assembly,
thermally
induced
phase
separation,
3D-printing
techniques.
Next,
summarize
polymers
preparation
utilizing
scaffolds.
We
then
review
application
drug-loaded
considering
different
stages
healing
acts.
Finally,
briefly
describe
stimulus-responsive
schemes
scaffolds,
other
exciting
systems.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(16)
Published: Feb. 1, 2024
Abstract
Intractable
infected
microenvironments
caused
by
drug‐resistant
bacteria
stalls
the
normal
course
of
wound
healing.
Sono‐piezodynamic
therapy
(SPT)
is
harnessed
to
combat
pathogenic
bacteria,
but
superabundant
reactive
oxygen
species
(ROS)
generated
during
SPT
inevitably
provoke
severe
inflammatory
response,
hindering
tissue
regeneration.
Consequently,
an
intelligent
nanocatalytic
membrane
composed
poly(lactic‐co‐glycolic
acid)
(PLGA)
and
black
phosphorus
/V
2
C
MXene
bio‐heterojunctions
(2D
‐bioHJs)
devised.
Under
ultrasonication,
2D
‐bioHJs
effectively
eliminate
disrupting
metabolism
electron
transport
chain
(ETC).
When
ultrasonication
ceases,
they
enable
elimination
SPT‐generated
ROS.
The
act
as
a
“lever”
that
achieves
balance
between
ROS
generation
annihilation,
delivering
both
antibacterial
anti‐inflammatory
properties
engineered
membrane.
More
importantly,
in
vivo
assays
corroborate
membranes
transform
stalled
chronic
environment
into
regenerative
one
eradicating
bacterial
population,
dampening
NF‐κB
pathway
promoting
angiogenesis.
As
envisaged,
this
work
demonstrates
novel
tactic
arm
with
programmed
effects
remedy
refractory
wounds
from
drug‐fast
bacteria.
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(21), P. 7504 - 7523
Published: Jan. 1, 2023
Hydrogen-bonded
organic
frameworks
(HOFs)
are
an
emerging
attractive
class
of
highly
crystalline
porous
materials
characterized
by
significant
biocompatibility,
rich
chemical
functionalities
and
well-defined
porosity.
The
unique
advantages
including
metal-free
nature
reversible
binding
manner
significantly
distinguish
HOFs
from
other
in
the
biotechnology
biomedical
field.
However,
relevant
HOF
studies
still
remain
their
infancy
despite
promising
remarkable
results
that
have
been
presented
recent
years.
Due
to
intricate
dynamic
physiological
conditions,
major
challenge
lies
stability
structural
diversity
vivo.
In
this
Tutorial
Review,
we
summarize
common
building
blocks
for
construction
HOF-based
functional
biomaterials
latest
developments
biological
Moreover,
highlight
current
challenges
regarding
functionalization
along
with
corresponding
potential
solutions.
This
Review
will
a
profound
effect
future
years
on
design
applications
biomaterials.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(39)
Published: Aug. 11, 2023
The
separation
of
acetylene
(C2
H2
)
from
carbon
dioxide
(CO2
is
a
very
important
but
challenging
task
due
to
their
similar
molecular
dimensions
and
physical
properties.
In
terms
porous
adsorbents
for
this
separation,
the
CO2
-selective
materials
are
superior
C2
ones
because
cost-
energy-efficiency
have
been
rarely
achieved.
Herein
we
report
our
unexpected
discovery
first
hydrogen
bonded
organic
framework
(HOF)
constructed
simple
linker
2,4,6-tri(1H-pyrazol-4-yl)pyridine
(PYTPZ)
(termed
as
HOF-FJU-88)
highly
material.
HOF-FJU-88
two-dimensional
HOFs
with
pore
pocket
about
7.6
Å.
activated
takes
up
high
amount
(59.6
cm3
g-1
at
ambient
conditions
record
IAST
selectivity
1894.
Its
performance
/C2
has
further
confirmed
through
breakthrough
experiments,
in
situ
diffuse
reflectance
infrared
spectroscopy
simulations.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(22)
Published: April 22, 2024
Abstract
Hydrogen‐bonded
organic
frameworks
(HOFs)
are
emerging
porous
materials
that
show
high
structural
flexibility,
mild
synthetic
conditions,
good
solution
processability,
easy
healing
and
regeneration,
recyclability.
Although
these
properties
give
them
many
potential
multifunctional
applications,
their
unstable
due
to
the
presence
of
only
weak
reversible
hydrogen
bonds.
In
this
work,
development
history
synthesis
methods
HOFs
reviewed,
categorize
design
concepts
strategies
improve
stability.
More
importantly,
significant
latest
HOF‐related
research
for
addressing
energy
environmental
issues,
work
discusses
advances
in
storage
conversion,
substance
generation
isolation,
detection
degradation
transformation,
biological
applications.
Furthermore,
a
discussion
coupling
orientation
HOF
cross‐cutting
fields
environment
is
presented
first
time.
Finally,
current
challenges,
opportunities,
advance
applications
discussed.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(46)
Published: Sept. 29, 2023
Precise
synthesis
of
topologically
predictable
and
discrete
molecular
crystals
with
permanent
porosities
remains
a
long-term
challenge.
Here,
we
report
the
first
successful
series
11
isoreticular
multivariate
hydrogen-bonded
organic
frameworks
(MTV-HOFs)
from
pyrene-based
derivatives
bearing
-H,
-CH3
,
-NH2
-F
groups
achieved
by
shape-fitted,
π-π
stacking
self-assembly
strategy.
These
MTV-HOFs
are
single-crystalline
materials
composed
tecton,
as
verified
single-crystal
diffraction,
nuclear
magnetic
resonance
(NMR)
spectra,
Raman
water
sorption
isotherms
density
functional
theory
(DFT)
calculations.
exhibit
tunable
hydrophobicity
uptake
starting
50
to
80
%
relative
humidity,
adjusting
combinations
ratios
groups.
As
proof
application,
resulting
were
shown
be
capable
capturing
mustard
gas
simulant,
2-chloroethyl
ethyl
sulfide
(CEES)
moisture.
The
location
different
within
pores
leads
synergistic
effect,
which
resulted
in
superior
CEES/H2
O
selectivity
(up
94
%)
compared
that
HOFs
only
pure
component
enhanced
breakthrough
performance
4000
min/g)
when
benchmark
MOF
materials.
This
work
is
an
important
advance
MTV-HOFs,
provides
platform
for
development
porous
numerous
applications.
