Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 18, 2024
Abstract
Electrodynamic
therapy
(EDT)
is
a
promising
alternative
approach
for
antibacterial
therapy,
as
reactive
oxygen
species
(ROS)
are
produced
efficiently
in
response
to
an
electric
field
without
relying
on
endogenous
H
2
O
and
.
However,
the
inherent
toxicity
of
metallic
catalysts
numerous
bacterial
toxins
during
therapeutic
process
still
hinder
its
development.
Herein,
biomimetic
metal–organic
(MOF@EV)
nanosponges
composed
ginger‐derived
extracellular
vesicles
(EVs),
electrodynamic
frameworks
(MOFs)
developed
eradication
infections
absorption
toxins.
The
prolonged
circulation
time
MOF@EV
vivo
facilitates
their
accumulation
at
infection
sites.
More
interestingly,
can
behave
effectively
prevent
host
cells
from
binding
toxins,
thereby
reducing
damage
cells.
Subsequently,
discovered
work
electro‐sensitizers,
which
confirmed
through
both
theoretical
calculation
experimental
verification.
As
result,
ROS
continuously
under
achieve
effective
EDT‐mediated
eradication.
Meanwhile,
treatment
visualized
mice
infected
with
luciferase‐expressing
Staphylococcus
aureus
(
S.
),
excellent
biofilm
capacity
detoxification
efficiency
demonstrated
subcutaneous
abscess
model.
This
provides
strategy
infections.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(38)
Published: April 23, 2024
Abstract
Currently,
microbial
infections
have
posed
an
arduous
challenge
to
global
public
health,
whereas
the
rise
of
antibiotic
resistance
is
rendering
traditional
therapies
futile,
prompting
development
new
antimicrobial
technologies.
Photoactive
nanomaterials
thus
garnered
a
thriving
interest
for
disinfection
owing
their
superior
antibacterial
efficaciousness,
favorable
biosafety,
and
rapidness
spatiotemporal
precision
in
excreting
bactericidal
actions.
The
review
summarizes
recent
advances
emerging
trends
design,
nanoengineering,
bioapplications
photoactive
antimicrobials.
It
commences
by
elaborating
fundamental
theories
on
bacterial
resistance,
mechanisms
phototherapy.
Subsequently,
regulation
effectiveness
comprehensively
discussed,
centering
criteria
strategies
tuning
photoabsorption
spectra,
photothermal
conversion,
photocatalytic
efficiency,
alongside
tactics
enabling
synergistic
therapies.
This
followed
comparative
analyses
techniques
modalities
synthesizing
engineering
with
diverse
structures,
forms,
functionalities.
Thereafter,
state‐of‐the‐art
applications
phototherapies
across
various
medical
sectors
are
portrayed,
key
challenges
opportunities
finally
discussed
spur
future
innovations
translation.
envisaged
provide
useful
guidance
devising
developing
nanomaterials‐based
photoresponsive
antimicrobials
application‐specific
materials
properties
biological
functions.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
Antibiotic-resistant
bacteria
often
cause
lethal
infections
in
both
the
surficial
and
deep
organs
of
humans.
Failure
antibiotics
resistant
leads
to
more
effective
alternative
therapies,
like
spatiotemporally
controllable
piezodynamic
therapy
(PZDT)
with
penetration.
Currently,
PZDT
demands
further
investigation
for
improved
treatment
outcomes
corresponding
therapeutic
mechanisms.
Herein,
a
nanocomposite
cloaked
is
reported
biomimetic
coating
TLR-upregulated
macrophage
membrane
targeted
against
MRSA-induced
skin
wound
infection
osteomyelitis,
representing
models,
respectively.
To
boost
efficacy,
crystal
defect
engineering
applied
by
impregnating
Fe2+
into
bismuth
oxy-iodide
nanosheets
increase
defects.
This
results
significantly
higher
piezoelectric
coefficient
than
previous
reports,
contributing
an
amplified
reactive
oxygen
species
generation
bacterial
killing.
More
importantly,
notable
effect
not
only
re-programs
macrophages
anti-inflammatory
M2
phenotype
accelerating
healing
but
also
stimulates
opening
piezo-stimulated
Ca2+
channels
boosts
differentiation
mesenchymal
stem
cells
osteoblasts
expediting
bone
tissue
repair
osteomyelitis
model.
Moreover,
Fe-doping
supplements
T2-magnetic
resonance
imaging
real-time
visualization
distribution.
theranostic
system
opens
new
avenue
future
drug-resistant
bacteria-caused
diseases.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 5, 2025
MXene-based
materials
have
attracted
significant
interest
due
to
their
distinct
physical
and
chemical
properties,
which
are
relevant
fields
such
as
energy
storage,
environmental
science,
biomedicine.
MXene
has
shown
potential
in
the
area
of
tissue
regenerative
medicine.
However,
research
on
its
applications
regeneration
is
still
early
stages,
with
a
notable
absence
comprehensive
reviews.
This
review
begins
detailed
description
intrinsic
properties
MXene,
followed
by
discussion
various
nanostructures
that
can
form,
spanning
from
0
3
dimensions.
The
focus
then
shifts
biomaterials
engineering,
particularly
immunomodulation,
wound
healing,
bone
regeneration,
nerve
regeneration.
MXene's
physicochemical
including
conductivity,
photothermal
characteristics,
antibacterial
facilitate
interactions
different
cell
types,
influencing
biological
processes.
These
highlight
modulating
cellular
functions
essential
for
Although
developing,
versatile
structural
attributes
suggest
role
advancing
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
Abstract
Bacterial
infection
has
become
the
most
dangerous
factor
in
tissue
repair,
which
strongly
affects
regeneration
efficiency
and
wellness
of
patients.
Piezoelectric
materials
exhibit
outstanding
advantage
producing
electrons
without
external
power
supply.
The
ability
electron
enrichment
reactive
oxygen
species
generation
through
noninvasive
stimulations
enables
piezoelectric
potential
applications
antibacterial.
Many
studies
have
proved
feasibility
as
a
functional
addition
antibacterial
biomaterial.
In
fact,
numerous
with
ingenious
designs
are
reported
to
be
effective
processes.
This
review
summarizes
mechanisms
piezoelectric,
illuminating
their
combating
bacteria.
Recent
advancement
design
construction
biomaterial
including
defect
engineering,
heterojunction,
synergy
metal
composite
scaffold
configuration
thoroughly
reviewed.
Moreover,
therapeutic
effects
common
tissues
requirements
introduced,
such
orthopedics,
dental,
wound
healing.
Finally,
development
prospects
points
deserving
further
exploration
listed.
is
expected
provide
valuable
insight
into
relationship
between
processes
materials,
inspiring
constructive
this
emerging
scientific
discipline.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 17, 2025
Bacterial
infections
in
wounds
and
bacteremia
present
significant
global
health
challenges,
driving
the
urgent
need
for
innovative
alternatives
to
traditional
antibiotics.
Here,
development
of
PEI-EDTA-2Na
carbon
quantum
dots
(PECDs)
synthesized
via
a
hydrothermal
method
is
reported.
Synthesis
conditions
affect
PECDs'
antibacterial
efficacy;
those
at
180
°C
have
optimal
-NH2
functionalization
better
adhesion
activity.
PECDs
are
pH
-
responsive,
eradicating
bacteria
weakly
acidic
by
disrupting
DNA
proteins.
Following
resolution
infection,
adapt
neutral
alkaline
environments,
where
they
scavenge
reactive
oxygen
species
(ROS),
reduce
inflammation,
promote
macrophage
polarization,
accelerate
wound
healing.
Furthermore,
significantly
improve
survival
models.
Their
intrinsic
fluorescence
enables
real-time
monitoring
wounds,
offering
non-invasive
diagnostic
tool.
Genomic
transcriptomic
analyses
reveal
that
disrupt
bacterial
metabolism
resistance
pathways,
while
simultaneously
supporting
anti-inflammatory
responses
during
tissue
repair.
This
dual
functionality-combining
therapeutic
efficacy
healing
with
antimicrobial
properties
bacteremia-positions
as
versatile
platform
smart
management
an
emerging
candidate
advanced
biomedical
applications.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(48)
Published: Oct. 13, 2024
Phototherapy,
such
as
photothermal
therapy
(PTT)
and
photodynamic
(PDT)
has
been
a
powerful
strategy
to
combat
bacterial
infection.
However,
the
compact
cell
membranes
of
pathogenic
bacteria,
especially
drug-resistant
significantly
diminish
efficiency
heat
conduction
impede
entrance
reactive
oxygen
species
(ROS)
into
cells,
resulting
in
unsatisfactory
sterilization.
Enlightened
by
membrane
feature
competent
herein
MXene/CaO
