A cationic hydrogel for visual diagnosis and treatment of bacterial-infected wounds via mild, on-demand dual-phototherapy DOI
Yi Cao, Na Li,

Manyu Chen

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160984 - 160984

Published: Feb. 1, 2025

Language: Английский

Design and Nanoengineering of Photoactive Antimicrobials for Bioapplications: from Fundamentals to Advanced Strategies DOI

Huilong Xin,

Yuanyuan Liu, Yinan Xiao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(38)

Published: April 23, 2024

Abstract Currently, microbial infections have posed an arduous challenge to global public health, whereas the rise of antibiotic resistance is rendering traditional therapies futile, prompting development new antimicrobial technologies. Photoactive nanomaterials thus garnered a thriving interest for disinfection owing their superior antibacterial efficaciousness, favorable biosafety, and rapidness spatiotemporal precision in excreting bactericidal actions. The review summarizes recent advances emerging trends design, nanoengineering, bioapplications photoactive antimicrobials. It commences by elaborating fundamental theories on bacterial resistance, mechanisms phototherapy. Subsequently, regulation effectiveness comprehensively discussed, centering criteria strategies tuning photoabsorption spectra, photothermal conversion, photocatalytic efficiency, alongside tactics enabling synergistic therapies. This followed comparative analyses techniques modalities synthesizing engineering with diverse structures, forms, functionalities. Thereafter, state‐of‐the‐art applications phototherapies across various medical sectors are portrayed, key challenges opportunities finally discussed spur future innovations translation. envisaged provide useful guidance devising developing nanomaterials‐based photoresponsive antimicrobials application‐specific materials properties biological functions.

Language: Английский

Citations

33
Defect‐Engineered Biomimetic Piezoelectric Nanocomposites With Enhanced ROS Production, Macrophage Re‐polarization, and Ca2+ Channel Activation for Therapy of MRSA‐Infected Wounds and Osteomyelitis DOI Open Access
Shubham Roy, Shaohua Wang, Zia Ullah

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Antibiotic-resistant bacteria often cause lethal infections in both the surficial and deep organs of humans. Failure antibiotics resistant leads to more effective alternative therapies, like spatiotemporally controllable piezodynamic therapy (PZDT) with penetration. Currently, PZDT demands further investigation for improved treatment outcomes corresponding therapeutic mechanisms. Herein, a nanocomposite cloaked is reported biomimetic coating TLR-upregulated macrophage membrane targeted against MRSA-induced skin wound infection osteomyelitis, representing models, respectively. To boost efficacy, crystal defect engineering applied by impregnating Fe2+ into bismuth oxy-iodide nanosheets increase defects. This results significantly higher piezoelectric coefficient than previous reports, contributing an amplified reactive oxygen species generation bacterial killing. More importantly, notable effect not only re-programs macrophages anti-inflammatory M2 phenotype accelerating healing but also stimulates opening piezo-stimulated Ca2+ channels boosts differentiation mesenchymal stem cells osteoblasts expediting bone tissue repair osteomyelitis model. Moreover, Fe-doping supplements T2-magnetic resonance imaging real-time visualization distribution. theranostic system opens new avenue future drug-resistant bacteria-caused diseases.

Language: Английский

Citations

2
BioHJzyme-Armed Hydrogel for Infectious Wound Monitoring Through Enzyme-Mimetic Antibacterial Activities and Macrophage Regulation DOI

Zuyao Wang,

Miaomiao He,

Xinyan Pang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 488, P. 151005 - 151005

Published: April 4, 2024

Language: Английский

Citations

8
Advancements in nanozymes research for the management of chronic wounds DOI

Duoduo Chen,

Guoxin Tan,

Shujian Tian

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157299 - 157299

Published: Nov. 1, 2024

Language: Английский

Citations

8
Intelligent sequential degradation hydrogels by releasing bimetal-phenolic for enhanced diabetic wound healing DOI
Yiwen Zhang,

Zixuan Tang,

Liyun Chen

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 378, P. 961 - 981

Published: Jan. 1, 2025

Language: Английский

Citations

1
Electroactive Asymmetric Dressing for Spatiotemporal Deep Burn Scarless Healing and Management DOI Open Access
Hanbai Wu, Xiong Zhou, Chuanwei Zhi

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Burn care and treatment differ markedly from other types of wounds, as they are significantly more prone to infections struggle maintain fluid balance post-burn. Moreover, the limited self-healing abilities exacerbate likelihood scar formation, further complicating recovery process. To tackle these issues, an asymmetric wound dressing comprising a quercetin-loaded poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB@Qu) hydrophilic layer zinc oxide nanoparticle-loaded, thermally treated polyvinylidene fluoride (HPVDF@ZnO) hydrophobic is designed. This provided antibacterial property exudate management in early stages burn treatment, preventing infection maintaining moisture at site. As healing progresses, electroactive properties HPVDF@ZnO quercetin P34HB@Qu synergistically regulate cell migration differentiation, accelerating facilitating scar-free regeneration. Furthermore, assisted regeneration skin appendages. study underscores full-cycle strategy versatile dressings for spatiotemporal injury scarless healing.

Language: Английский

Citations

1
Therapeutic Black Phosphorus Nanosheets Elicit Neutrophil Response for Enhanced Tumor Suppression DOI Creative Commons
Jing Wang, Weiqiang Yu, Hui Shen

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Black phosphorus (BP) has demonstrated potential as a drug carrier and photothermal agent in cancer therapy; however, its intrinsic functions treatment remain underexplored. This study investigates the immunomodulatory effects of polyethylene glycol‐functionalized BP (BP‐PEG) nanosheets breast models. Using immunocompetent mouse models‐including 4T1 orthotopic BALB/c mice MMTV‐PyMT transgenic mice, it is found that BP‐PEG significantly inhibits tumor growth metastasis without directly inducing cytotoxicity cells. Mass cytometry analysis reveals reshapes immune microenvironment by recruiting neutrophils. Neutrophil depletion experiments further demonstrate antitumor are dependent on Moreover, bulk single‐cell RNA sequencing indicate mainly taken up macrophages, leading to release inflammatory factors such IL1A CXCL2, which enhance neutrophil recruitment activation, thereby amplifying response. Finally, co‐culture assays confirm indeed enhances activity neutrophils natural killer (NK) These findings position an capable reprogramming promote innate immunity against cancer. By stimulating neutrophil‐mediated activity, offers unique therapeutic approach can potentially efficacy existing immunotherapies.

Language: Английский

Citations

1
Microneedle patch-involved local therapy synergized with immune checkpoint inhibitor for pre- and post-operative cancer treatment DOI
Yue Yin, Lu Tang,

Yuqi Cao

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 678 - 695

Published: Jan. 24, 2025

Language: Английский

Citations

1
Endogenous electric field-driven neuro-immuno-regulatory scaffold for effective diabetic wound healing DOI
Zhiqing Liu, Tianlong Wang, Jinhui Zhao

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 266 - 282

Published: Jan. 25, 2025

Language: Английский

Citations

1
Engineering Multifunctional Surface Topography to Regulate Multiple Biological Responses DOI Creative Commons

Mohammad Asadi Tokmedash,

Changheon Kim,

Ajay P Chavda

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123136 - 123136

Published: Jan. 1, 2025

Language: Английский

Citations

1