Dynamic hierarchical ligand anisotropy for competing macrophage regulation in vivo

Bioactive Materials, Journal Year: 2025, Volume and Issue: 47, P. 121 - 135

Published: Jan. 19, 2025

Language: Английский

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“Mix‐and‐Match”: Self‐Sorting Assembly Governed Supramolecular Polymeric Nanomedicine for Boosting Combined Chemo/Phototherapy

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Precise cancer nanomedicine requires rational molecular instructions of therapeutic agents. Harnessing the structure‐property‐function relationships represents a practical strategy toward smart and effective nanomedicine. A structurally novel hydrogen‐bonded (H‐bonded) supramolecular nanoformulation generated by orthogonal self‐sorting assembly chemo‐prodrug (FPtF) phototherapeutics (BPeB) is here reported, to reach an autonomous with improved anti‐tumor efficacy combining chemo/phototherapy (CT/PT). The high‐fidelity H‐bonding modularity from privileged heterocomplementary diaminopyridine/5‐fluorouracil (DAP/FU) Hamilton wedge/barbiturate (HW/Ba) pairs, respectively enable precise spatial control binding interactions FPtF BPeB, in turn allowing process specific “mix‐and‐match” capability. To directly stimulate phototherapy BPeB via near‐infrared (NIR) light, spectral matched upconversion nanoparticles (UCNPs, β‐NaYF 4 :Yb,Er) are encapsulated simultaneously. As result, polymeric nanomicelles, i.e., F/B/U@PHDO, readily fabricated. Moreover, distinct association constant (Ka) DAP/FU (≈10 2 M −1 ) HW/Ba 4‐5 pairs reflect different strengths stabilities H‐bonds, thus endowing programmable dissociation, accompanied release through pH/thermal‐stimuli. Therapeutic regime appreciated outcomes ultimately accomplished combined CT/PT. opportunities offered design anticipated point new paradigm for therapy.

Language: Английский

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Simvastatin-Loaded Polymeric Nanoparticles: Targeting Inflammatory Macrophages for Local Adipose Tissue Browning in Obesity Treatment

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 29, 2024

Obesity is defined as chronic, low-grade inflammation within specific tissues. Given the escalating prevalence of obesity among individuals all ages, has reached epidemic proportions, posing an important public health challenge. Despite significant advancements in treating obesity, conventional approaches remain largely ineffective or involve severe side effects, thus underscoring pressing need to explore and develop treatment approaches. Targeted local immunomodulation using nanoparticles (NPs) can influence fat production utilization processes. Statins, known for their anti-inflammatory properties, show potential mitigating obesity-related inflammation. A localized delivery option offers several advantages over oral parenteral methods. Here, we developed simvastatin (Sim) encapsulated PLGA NPs (Sim-NP) Sim adipose tissues (ATs) treat obesity. In vitro experiments revealed strong effects Sim-NPs, which resulted enhanced modulation macrophage (MΦ) polarization induction AT browning. We then extended our investigation

Language: Английский

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Stimuli‐Mediated Macrophage Switching, Unraveling the Dynamics at the Nanoplatforms–Macrophage Interface

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(20)

Published: April 19, 2024

Abstract Macrophages play an essential role in immunotherapy and tissue regeneration owing to their remarkable plasticity diverse functions. Recent bioengineering developments have focused on using external physical stimuli such as electric magnetic fields, temperature, compressive stress, among others, micro/nanostructures induce macrophage polarization, thereby increasing therapeutic potential. However, it is difficult find a concise review of the interaction between stimuli, advanced micro/nanostructures, polarization. This examines present research stimuli‐induced polarization micro/nanoplatforms, emphasizing synergistic fabricated structure stimulation for regeneration. A overview advancements investigating impact including forces, fluid shear photothermal multiple stimulations macrophages within complex engineered structures, provided. The prospective implications these strategies regenerative medicine immunotherapeutic approaches are highlighted. will aid creating stimuli‐responsive platforms immunomodulation

Language: Английский

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Immunomodulatory and immune-toxicological role of nanoparticles: Potential therapeutic applications

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 135, P. 112251 - 112251

Published: May 22, 2024

Language: Английский

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Β-Cyclodextrin-based materials for 3D printing, cancer therapy, tissue engineering, and wound healing

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 157272 - 157272

Published: Oct. 1, 2024

Language: Английский

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Photonic control of ligand nanospacing in self-assembly regulates stem cell fate

Bioactive Materials, Journal Year: 2023, Volume and Issue: 34, P. 164 - 180

Published: Dec. 26, 2023

Extracellular matrix (ECM) undergoes dynamic inflation that dynamically changes ligand nanospacing but has not been explored. Here we utilize ECM-mimicking photocontrolled supramolecular ligand-tunable Azo

Language: Английский

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Multimodal synergistic ferroptosis cancer therapy

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216236 - 216236

Published: Sept. 25, 2024

Language: Английский

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Cancer Cell Membrane‐Based Materials for Biomedical Applications

Small, Journal Year: 2023, Volume and Issue: 20(7)

Published: Oct. 9, 2023

Abstract The nanodelivery system provides a novel direction for disease diagnosis and treatment; however, its delivery effectiveness is restricted by the short biological half‐life inadequate tumor targeting. immune evasion properties homologous targeting capabilities of natural cell membranes, particularly those cancer membranes (CCM), have gained significant interest. integration CCM nanoparticles has resulted in emergence CCM‐based nanoplatforms (CCM‐NPs), which attention due to their unique properties. CCM‐NPs not only prolong blood circulation time core nanoparticles, but also direct them Herein, history development as well how these platforms been used biomedical applications are discussed. application therapy will be described detail. Translational efforts currently under way further research address key areas need ultimately required facilitate successful clinical adoption CCM‐NPs.

Language: Английский

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PEDF-enriched extracellular vesicle for vessel normalization to potentiate immune checkpoint blockade therapy

Biomaterials Research, Journal Year: 2024, Volume and Issue: 28

Published: Jan. 1, 2024

The abnormal tumor vasculature acts as the physical and functional barrier to infiltration activity of effector T cells, leading low response rate immune checkpoint inhibitors (ICIs). Herein, antiangiogenic extracellular vesicles that enable normalization tumor-associated were prepared potentiate efficacy ICIs. Small exploited delivery platform protect protein, pigment epithelium-derived factor (PEDF), from proteolytic degradation. Along with physicochemical characteristics PEDF-enriched (P-EVs), their inhibitory effects on migration, proliferation, tube formation endothelial cells investigated in vitro. In tumor-bearing mice, it was confirmed that, compared bare PEDFs, P-EVs efficiently reduced vessel leakiness, improved blood perfusion, attenuated hypoxia. Consequently, when combined anti-PD-1 antibodies, remarkably augmented antitumor immunity, evidenced by increased CD8 + regulatory cells. These results suggest are promising therapeutics for tumors refractory

Language: Английский

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