Talanta, Journal Year: 2024, Volume and Issue: 285, P. 127438 - 127438
Published: Dec. 24, 2024
Language: Английский
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)
Published: May 22, 2024
Abstract Recently, field‐effect transistors (FETs) have emerged as a novel type of multiparameter, high‐performance, highly integrated platform for biochemical detection, leveraging their classical three‐terminal structure, working principles, and fabrication methods. Notably, graphene materials, known exceptional electrical optical properties well biocompatibility, serve fundamental component these devices, further enhancing advantages in biological detection. This review places special emphasis on recent advancements transistor (GFET)‐based biosensors focuses four main areas: i) the basic concepts FETs specific GFETs; ii) various state‐of‐the‐art approaches to enhance performance GFET‐based terms operating principles “3S”—stability, sensitivity, specificity; iii) multiplexed detection strategies biosensors; iv) current challenges future perspectives field biosensors. It is hoped that this article can profoundly elucidate development GFET inspire broader audience.
Language: Английский
Citations
16
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(15)
Published: Jan. 30, 2024
On-site diagnostic tests that accurately identify disease biomarkers lay the foundation for self-healthcare applications. However, these routinely rely on single-mode signals and suffer from insufficient accuracy, especially multiplexed point-of-care (POCTs) within a few minutes. Here, this work develops dual-mode multiclassification platform integrates an electrochemiluminescence sensor field-effect transistor in microfluidic chip. The channel guides testing samples to flow across electro-optical units, which produce readouts by detecting infectious of tuberculosis (TB), human rhinovirus (HRV), group B streptococcus (GBS). Then, machine-learning classifiers generate three-dimensional (3D) hyperplanes diagnose different diseases. Dual-mode derived distinct mechanisms enhance anti-interference ability physically, machine-learning-aided diagnosis high-dimensional space reduces occasional inaccuracy mathematically. Clinical validation studies with 501 unprocessed indicate has accuracy approaching 99%, higher than 77%-93% rapid technologies at 100% statistical power (>150 clinical tests). Moreover, time is 5 min without trade-off accuracy. This solves issue on-site diagnosis, endowing POCT systems same as laboratory holding unique prospects complicated scenes personalized healthcare.
Language: Английский
Citations
12
Journal of Biotechnology, Journal Year: 2025, Volume and Issue: 400, P. 29 - 47
Published: Feb. 15, 2025
Language: Английский
Citations
1
Advanced Electronic Materials, Journal Year: 2024, Volume and Issue: 10(4)
Published: Jan. 16, 2024
Abstract Supercapacitors and transistors are two key devices for future electronics that must combine portability, high performance, easy scalability, etc. Graphene‐related materials (GRMs) frequently chosen as active these applications given their unique physical properties tunable via chemical functionalization. Up to date, among GRMs, only reduced graphene oxide (rGO) showed sufficient versatility processability in mild media, rendering it suitable integration types of devices. Here, a sound alternative rGO is provided, namely acetic acid (GAA), whose physico‐chemical features offer specific advantages. In particular, the use GAA‐based cathode zinc hybrid supercapacitor (Zn‐HSC) delivers state‐of‐the‐art gravimetric capacitance ≈400 F g −1 at current density 0.05 A . Conversely, LGT, supported onto Si/SiO 2 , shows an ambipolar behavior 0.1 m NaCl, featuring clear p‐doping quantified by Dirac voltage higher than 100 mV. Such device successfully implemented paper fluidics, thereby demonstrating feasibility real‐time monitoring.
Language: Английский
Citations
7
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: July 14, 2024
Abstract Accurate and rapid quantification of cytokines in biofluids is crucial for early disease diagnosis, management, prevention. However, it still remains challenging existing sensors due to the broad dynamic range high interference from sample matrices. To overcome these challenges, electrochemical (EC) field‐effect transistor (FET) dual‐mode biosensing integrated on an extended‐gate carbon nanotube transistor. This biosensor chip effectively eliminates direct contact between device solution employs independent signal readouts based two distinct response mechanisms, thereby circumventing limitations associated with conventional biosensors. Selective detection cytokine (e.g., Interferon‐γ, IFN‐γ) achieved by FET sensing mode (0.1 4000 pg mL −1 , a limit 24.1 fg ) EC (0.4–2000 ng at different concentration range. The feasibility real analysis using EC‐FET confirmed detecting salivary levels IFN‐γ. combination modes not only provides sensitivity wide (seven orders magnitude) accommodate various biological samples but also improves reliability results, which shows promising applications diagnosis.
Language: Английский
Citations
4
Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(41)
Published: July 22, 2024
Abstract Given the high degree of variability and complexity cancer, precise monitoring logical analysis different nucleic acid markers are crucial for improving diagnostic precision patient survival rates. However, existing molecular methods normally suffer from cost, cumbersome procedures, dependence on specialized equipment requirement in‐depth expertise in data analysis, failing to analyze multiple cancer‐associated provide immediate results a point‐of‐care manner. Herein, we demonstrate transistor‐based DNA computing (TDMC) platform that enables simultaneous detection microRNA (miRNA) single transistor. TDMC can perform not only basic operations such as “AND” “OR”, but also complex cascading computing, opening up new dimensions multi‐index analysis. Owing efficiency, sensing computations multi‐analytes be operated transistor at concentration low 2×10 −16 M, reaching lowest computing. Thus, achieves an accuracy 98.4 % diagnosis hepatocellular carcinoma 62 serum samples. As convenient accurate platform, holds promise applications “one‐stop” personalized medicine.
Language: Английский
Citations
4
Talanta, Journal Year: 2025, Volume and Issue: unknown, P. 127637 - 127637
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Sustainable Agriculture and Environment, Journal Year: 2025, Volume and Issue: 4(1)
Published: Feb. 5, 2025
ABSTRACT Microbial volatile organic compounds (mVOCs) are crucial to the ecological interactions of plants and microbes, playing pivotal roles in plant defence, communication, growth promotion. The classification, biosynthesis, emission processes mVOCs, their multifaced functions activities within ecosystems have been extensively studied. Moreover, signalling pathways that enable mVOCs‐mediated communication between surrounding environment explored. mVOCs critical mediating with biotic abiotic stressors, including pathogens environmental changes. These contribute enhanced resilience foster beneficial interactions. Biotechnological great potential sustainable agriculture, especially natural pest management crop protection. applications include various disease control strategies, such as biosensors, highlighting role promoting supporting development growth. In this review, we explored mechanisms action, types We also discussed recent developments use challenges involved. ethical regulatory issues related using agriculture biotechnology effects on human health environment. Finally, highlight research gaps fully leverage mVOC for production health.
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 9, 2025
The accurate diagnosis of pancreatic ductal adenocarcinoma (PDAC) suffers low specify, and sensitivity biomarker detection. In complex biological fluid environments, nonspecific adsorption is prevalent, posing challenges to the detection biomarkers at concentrations. Herein, a highly sensitive selective solution-gated graphene transistor (SGGT) fabricated for miRNA-196a in exosomes diagnose PDAC. antifouling modification on surface gate electrode employed through using bovine serum albumin as common sealing agent poly adenine (polyA8) enhance hydrophilicity. effect background noise effectively reduced. limit reached 1.82 × 10-19 m without need labeling or amplification, time within 25 min. clinical experiments verify that receiver operating characteristic curve values are higher than carbohydrate antigen 19-9 biomarker, high 0.98. can well distinguish PDAC from non-PDAC subjects. SGGT sensor platform demonstrates significant potential milieu samples.
Language: Английский
Citations
0
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
Abstract Recent research has demonstrated the potential of photogating in regulating characteristics photoelectrochemical transistors. Here it is reported graphene transistor (GPECT) with dual‐directional signal‐on biosensing as exemplified by channel gated p/n‐type metal–organic frameworks (MOFs) upon light illumination toward aptasensing. Due to shift Dirac point induced MOFs, operation mutually verifiable dual readout could be achieved. For aptasensing, assistance biocatalytic precipitation reaction, such a device validated for highly sensitive detection thrombin limits low 5.2 and 0.1 f m , respectively. This study demonstrates not only general protocol GPECTs but also unique novel optoelectronics.
Language: Английский
Citations
0