Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(19)
Published: March 19, 2024
Abstract
There
is
a
substantially
ascending
demand
for
nonantibiotic
strategies
to
overcome
the
resistance
of
bacterial
infections.
Here,
discovery
distinctive
antibacterial
structure
reported.
The
novel
nanoparticle
strategy
proposed
appreciable
bacteria
killing
by
smart
design
delayed
addition
crosslinkers
into
reaction
mixture.
[2‐(methacryloyloxy)ethyl]trimethylammonium
chloride
solution
(MTCl),
water‐soluble
ionic
liquid
(IL),
has
narrow‐size
material
distribution,
good
whiteness,
and
high
weather
resistance.
quaternary
ammonium
salt
utilized
efficiently
permeate
cell
membranes
through
electrostatic
interaction,
accordingly,
boasting
beneficiary
properties.
More
importantly,
it
allows
attach
nanomaterials
easily,
especially
double‐shelled
nanosphere.
In
light
introduction
9‐amino(9‐deoxy)ep‐quinine
(QNNH
2
)
on
its
inner
shell,
blocks
nucleic
acid
glucose
metabolism
in
bacteria,
which
betterment
activity
compared
other
nanomaterials.
This
physical/chemical/biological
triple
process
eliminates
need
traditional
antibiotics,
fabrication
properties
described
here
provide
insights
based
chemical
physical
effects.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(23)
Published: April 3, 2024
Abstract
Cuproptosis
is
an
emerging
cell
death
pathway
that
depends
on
the
intracellular
Cu
ions.
Elesclomol
(ES)
as
efficient
ionophore
can
specifically
transport
into
mitochondria
and
trigger
cuproptosis.
However,
ES
be
rapidly
removed
metabolized
during
intravenous
administration,
leading
to
a
short
half‐life
limited
tumor
accumulation,
which
hampers
its
clinical
application.
Here,
study
develops
reactive
oxygen
species
(ROS)‐responsive
polymer
(PCP)
based
cinnamaldehyde
(CA)
polyethylene
glycol
(PEG)
encapsulate
ES‐Cu
compound
(EC),
forming
ECPCP.
ECPCP
significantly
prolongs
systemic
circulation
of
EC
enhances
accumulation.
After
cellular
internalization,
PCP
coating
stimulatingly
dissociates
exposing
high‐level
ROS,
releases
Cu,
thereby
triggering
via
Meanwhile,
2+
‐stimulated
Fenton‐like
reaction
together
with
CA‐stimulated
ROS
production
simultaneously
breaks
redox
homeostasis,
compensates
for
insufficient
oxidative
stress
treated
alone,
in
turn
inducing
immunogenic
cells,
achieving
simultaneous
cuproptosis
immunotherapy.
Furthermore,
excessive
accelerates
stimuli‐dissociation
ECPCP,
positive
feedback
therapy
loop
against
self‐alleviation.
Therefore,
nanoplatform
immunotherapy
improves
dual
antitumor
mechanism
provides
potential
optimization
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(30)
Published: May 4, 2024
Abstract
Low
efficacy
of
immunotherapy
due
to
the
poor
immunogenicity
most
tumors
and
their
insufficient
infiltration
by
immune
cells
highlights
importance
inducing
immunogenic
cell
death
activating
system
for
achieving
better
treatment
outcomes.
Herein,
ferroelectric
Bi
2
CuO
4
nanoparticles
with
rich
copper
vacancies
(named
BCO‐V
Cu
)
are
rationally
designed
engineered
ferroelectricity‐enhanced
apoptosis,
cuproptosis,
subsequently
evoked
immunotherapy.
In
this
structure,
suppressed
recombination
electron–hole
pairs
band
bending
polarization
lead
high
catalytic
activity,
triggering
reactive
oxygen
species
bursts
apoptosis.
The
fragments
produced
apoptosis
serve
as
antigens
activate
T
cells.
Moreover,
generated
charge
catalysis,
nanomedicine
can
act
“a
smart
switch”
open
membrane,
promote
nanomaterial
endocytosis,
shut
down
+
outflow
pathway
evoke
thus
a
strong
response
is
triggered
reduced
content
adenosine
triphosphate.
Ribonucleic
acid
transcription
tests
reveal
pathways
related
activation.
Thus,
study
firstly
demonstrates
feasible
strategy
enhancing
using
single
semiconductor‐induced
cuproptosis.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(44)
Published: Aug. 5, 2024
Implant-associated
infections
(IAIs)
are
the
main
cause
of
prosthetic
implant
failure.
Bacterial
biofilms
prevent
antibiotic
penetration,
and
unique
metabolic
conditions
in
hypoxic
biofilm
microenvironment
may
limit
efficacy
conventional
treatment.
Escaping
survival
bacteria
not
be
continually
eradicated,
resulting
recurrence
IAIs.
Herein,
a
sonosensitive
metal-organic
framework
Cu-TCPP
(tetrakis(4-carboxyphenyl)
porphyrin)
nanosheets
tinidazole
doped
probiotic-derived
membrane
vesicles
(OMVs)
with
high-penetration
sonodynamic
therapy
(SDT),
bacterial
state
interference,
cuproptosis-like
death
to
eradicate
IAIs
is
proposed.
The
can
convert
O
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 22, 2025
Abstract
The
emergence
of
antibiotic‐resistant
bacteria
has
exacerbated
the
challenge
treating
infectious
diseases.
Quorum
sensing
(QS),
a
bacterial
communication
system
regulating
virulence
and
biofilm
formation,
presents
target
for
novel
therapies.
Cuproptosis
death
is
innovation
mode
death,
however,
this
effect
may
be
partially
inhibited
by
glutathione
(GSH).
Buthionine
sulfoximine
(BSO)
responsible
GSH
biosynthesis
been
identified
as
potential
promoter
cuproptosis
death.
Here,
Cu
2
O‐BSO
NPs
with
lung
adhesion
mucus
penetration
ability
are
synthesized
incorporating
BSO
onto
O,
modifying
it
DOPA
PEG.
demonstrated
broad‐spectrum
antibacterial
activity
against
both
Gram‐positive
Gram‐negative
bacteria,
making
viable
treatment
option
MRSA‐induced
acute
pneumonia.
Specifically,
can
synergistically
enhance
cuproptosis‐like
hinder
QS
system,
eradicate
biofilms,
reduce
strains,
stimulate
chemotaxis
phagocytosis
macrophages,
ultimately
improve
in
mice
severe
This
research
wide‐ranging
alternative,
providing
promise
addressing
microbial
resistance
combatting
formation.
Additionally,
established
theoretical
foundation
clinical
numerous
challenging
cases
drug‐resistant
bacteria.
Colloids and Interface Science Communications,
Journal Year:
2024,
Volume and Issue:
61, P. 100791 - 100791
Published: June 1, 2024
Polyether
ether
ketone
(PEEK)
has
been
extensively
used
in
healthcare
due
to
its
excellent
mechanical
properties,
chemical
resistance,
and
biocompatibility.
Still,
weak
bactericidal
performance
allows
pathogenic
bacteria
easily
adhere
proliferate
on
the
PEEK
surface.
In
this
research,
physical
plasma
treatment
fluoridation
have
combined
enable
surface
with
stable
antibacterial
performance.
The
characteristics
of
morphology,
elemental
composition,
hydrophilicity
for
samples
characterized.
vitro
experiments
reveal
that
obtained
exhibited
great
antimicrobial
activity.
Furthermore,
effect
modified
shown
almost
no
variation
after
28
days
storage
at
room
temperature
4
h
121
°C,
confirming
property
high-temperature
stability.
This
study
presents
an
efficient
practical
method
enhance
cytocompatibility
properties
surface,
making
it
a
potential
medical
device
material.
