Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Fluorescence
imaging
in
the
second
near-infrared
region
(NIR-II,
1000-1700
nm)
has
garnered
considerable
attention
for
displaying
biological
information
of
deep
tissues.
However,
lack
biocompatible
contrast
agents
with
bright
NIR-II
emission
hampered
precise
clinical
application
tissue
imaging.
Here,
a
lipophilic
enhancement
strategy
employing
donor-acceptor-donor
(D-A-D)
molecules,
introducing
long
alkoxy
chains
and
quaternary
ammonium
salts
development
highly
water-soluble
fluorophores
(BBTD-2C-N),
is
described.
Notably,
liposome-encapsulated
BBTD-2C-N
nanoparticles
(B-2C-N/DMPC)
aqueous
solution
exhibit
1.8-fold
increase
fluorescence
brightness
compared
to
free
methanol.
Avoidance
aggregation-caused
quenching
effect
enhanced
are
attributed
significantly
attenuated
π-π
stacking
interactions
maintained
monodisperses
hydrophobic
liposome
shell.
Moreover,
demonstrates
superior
performance
visualizing
lipid
droplet-rich
HeLa
cells
vitro,
as
well
monitoring
adipose
fatty
liver
vivo.
This
study
reveals
new
avenue
vivo
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 3, 2024
Compared
with
conventional
therapies,
photoimmunotherapy
offers
precise
targeted
cancer
treatment
minimal
damage
to
healthy
tissues
and
reduced
side
effects,
but
its
efficacy
may
be
limited
by
shallow
light
penetration
the
potential
for
tumor
resistance.
Here,
an
acceptor-donor-acceptor
(A-D-A)-structured
nanoaggregate
is
developed
dual
phototherapy,
including
photodynamic
therapy
(PDT)
photothermal
(PTT),
triggered
single
near-infrared
(NIR)
light.
Benefiting
from
strong
intramolecular
charge
transfer
(ICT),
A-D-A-structured
nanoaggregates
exhibit
broad
absorption
extending
NIR
region
effectively
suppressed
fluorescence,
which
enables
deep
efficient
conversion
(η
=
67.94%).
A
suitable
HOMO-LUMO
distribution
facilitates
sufficient
intersystem
crossing
(ISC)
convert
ground-state
oxygen
(
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 1, 2024
Recent
advances
have
been
made
in
second
near-infrared
(NIR-II)
fluorescence
bioimaging
and
many
related
applications
because
of
its
advantages
deep
penetration,
high
resolution,
minimal
invasiveness,
good
dynamic
visualization.
To
achieve
high-performance
NIR-II
bioimaging,
various
materials
probes
with
bright
emission
extensively
explored
the
past
few
years.
Among
these
emissive
materials,
conjugated
polymers
small
molecules
attracted
wide
interest
due
to
their
native
biosafety
tunable
optical
performance.
This
review
summarizes
brightness
strategies
available
for
highlights
recent
developments
bioimaging.
A
concise,
detailed
overview
molecular
design
regulatory
approaches
is
provided
terms
brightness,
long
wavelengths,
superior
imaging
Then,
typical
cases
which
are
used
as
introduced
by
providing
step-by-step
examples.
Finally,
current
problems
challenges
associated
accessing
briefly
discussed,
significance
future
prospects
proposed
offer
helpful
guidance
development
materials.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 6, 2024
Abstract
Phototheranostics
with
second
near‐infrared
(NIR‐II)
emissions
show
great
potential
for
disease
diagnosis
and
imaging‐guided
phototherapy
owing
to
deep
tissue
penetration,
high
imaging
resolution,
excellent
tumor
eradication.
Recently,
molecular
conjugation
engineering
J‐aggregation
have
been
used
construct
organic
NIR‐II
materials.
However,
these
molecules
generally
extensive
large
weight
in
the
range
of
700–1700
g
mol
−1
,
requiring
complicated
design
synthesis.
Herein,
a
emissive
through‐space
charge‐transfer
(TSCT)
nanoparticle
(NP)
using
short‐conjugated
donor‐acceptor
(D‐A)
(TTP)
is
reported
high‐performance
bioimaging
cancer
phototheranostics.
Owing
short
TTP
molecule
small
only
518
monomer
possesses
visible
absorption
first
(NIR‐I)
emission.
Upon
forming
NPs
water,
efficient
TSCT
between
monomers
leads
significantly
red‐shifted
NIR‐I
emission
region
tail
that
extends
1400
nm.
are
employed
vivo
blood‐vessel
phototheranostics
successfully.
This
work
introduces
facile
strategy
based
on
D‐A
biomedical
applications.
Aggregate,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 22, 2024
ABSTRACT
Long‐term
in
vivo
fluorescence
analysis
is
growing
into
a
sparkling
frontier
gaining
deep
insights
various
biological
processes.
Exploration
of
such
fluorophores
with
high
performance
still
remains
an
appealing
yet
significantly
challenging
task.
In
this
study,
we
have
elaborately
integrated
second
near‐infrared
(NIR‐II)
emissive
fluorophore
the
metal
Pt
self‐assembled
prism‐like
metallacage
M‐DBTP,
which
enables
intravital
long‐term
tracking
through
NIR‐II
imaging
technologies.
addition,
bioimaging
metallacage‐loaded
nanoparticles
(NPs)
indicated
extraordinary
photographic
on
mice
blood
vessels
and
rapid
clearance
M‐DBTP
NPs
from
within
7
h.
The
subsequent
transfer
to
bones
retention
bone
marrow
region
for
up
35
days
was
revealed
by
analysis,
confirmed
distribution
metabolism
inductively
coupled
plasma
optical
emission
spectrometer.
Moreover,
bright
them
well
perform
imaging‐guided
tumor
surgery.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(44)
Published: July 18, 2024
Abstract
Exploiting
photothermal
agents
with
second‐near‐infrared
(NIR‐II,
1000−1700
nm)
emission
and
a
high
conversion
efficiency
(PCE)
is
an
appealing
challenging
task.
Herein,
by
simultaneously
tailoring
the
D−A
interaction
planarity
in
fluorophores,
two
donor‐acceptor
(D−A)
−type
semiconducting
polymers
(SPs),
T‐BTP
B‐BTP,
are
constructed.
Compared
T‐BTP,
B‐BTP
shows
increased
intramolecular
interactions
improved
molecular
planarity,
leading
to
bathochromic‐shift
absorption,
NIR‐II
emission,
PCE.
Notably,
NPs
achieve
remarkable
PCE
of
84.7%,
which
among
highest
PCEs
SPs
fluorescence
imaging‐guided
therapy
(PTT).
Because
these
promising
features,
successfully
used
vascular
imaging
cancer
therapy.
This
study
provides
valuable
guidelines
for
development
high‐performance
SPs.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 16, 2025
Abstract
NIR‐II
fluorescence
imaging
has
shown
broad
application
prospects
in
life
science
because
of
its
deeper
tissue
penetration
and
higher
spatiotemporal
resolution.
Developing
fluorophores
with
special
spectroscopic
properties
analytical
functions
become
a
cutting‐edge
but
challenging
topic
this
field.
Herein,
series
azulene‐based
(called
cyazulenes)
adjustable
cycloalkenes
for
applications
is
reported.
Cyazulenes
(CA965,
CA985,
CA1025)
are
constructed
via
the
convenient
coupling
azulene
derivatives.
They
exhibit
different
H‐aggregation
J‐aggregation.
Particularly
noteworthy
that
CA985
can
form
significant
J‐aggregates
strong
sharp
emission
biological
media,
be
used
vivo
blood
vessels
fine
structures
collecting
lymphatics
mice.
Moreover,
displays
passive
bone‐targeted
capacity,
thereby
enabling
bone
imaging.
This
study
demonstrates
chemical
impact
varying
on
aggregate
formation
spectral
cyazulenes,
which
will
advance
fluorophores.
Analytical Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
The
sensitive
detection
of
the
radioactive
thorium
(Th)
ion
with
an
oxidation
state
+4
(Th4+)
is
great
significance
for
environmental
protection
and
life
safety.
In
this
study,
five
fluorescence
sensors
regulated
donor-acceptor
(D-A)
interactions
were
constructed
Th4+
based
on
intramolecular
charge
transfer
aggregation-induced
emission
mechanisms.
Among
developed
sensors,
TPE-D
bearing
electron-deficient
π-bridge
weak
D-A
presented
ratiometric
behavior
toward
in
aqueous
solution
due
to
its
characteristics
unique
D-A-D
structures.
Moreover,
showed
excellent
selectivity
sensitivity
detection,
limit
was
as
low
8.1
×
10-8
M.
sensing
mechanism
observation
revealed
that
could
coordinate
hydroxyl,
imine,
carbonyl
groups
accompanied
by
electron
process.
addition,
selectively
be
enriched
lysosome.
Both
lysosome
liver
mice
zebrafish
realized
strategy,
a
mobile-assisted
approach
actual
water
samples
also
established
high
sensitivity.
This
first
report
organelles
organs,
which
provides
reliable
strategy
radionuclide
toxicology
analysis
applications.
