Plasmon-enhanced NIR-II photoluminescence of rare-earth oxide nanoprobes for high-sensitivity optical temperature sensing

Optics Letters, Journal Year: 2024, Volume and Issue: 49(22), P. 6489 - 6489

Published: Oct. 23, 2024

With ongoing advancements in photothermal therapy, achieving efficient tumor cell eradication while minimizing damage to healthy tissues necessitates a highly effective and non-invasive real-time temperature monitoring technique for human tissues. Herein, we report near-infrared (NIR)-II optical sensing nanoprobe featuring rare-earth-doped gadolinium oxide nanocrystals (RENCs) attached the dumbbell mesoporous silica-coated gold nanorods (AuNRs). The composite presents an intense absorption NIR region, NIR-II photoluminescence (PL) increases by 97.2 102-fold compared pure RENCs upon 980 nm irradiation. localized electric field generated through surface plasmon resonance effects of AuNRs demonstrated dumbbell-shaped distribution that aligns with structure nanoprobes, maximizing PL enhancement RENCs. Moreover, emissions are changed rising temperature, exceptional relative sensitivity 7.25% K

Language: Английский

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Optomagnetic Heater-Thermometer Nanoplatform for Tumor Magnetothermal Therapy with Operando Temperature Feedback

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Real-time temperature feedback during hyperthermia enables precise lesion ablation with minimal damage to healthy tissue. However, the lack of on-demand theranostic agents eludes such applications. This study demonstrates in vivo operando monitoring tumor magnetothermal therapy using an optomagnetic heater-thermometer nanocluster agent. agent was synthesized via a microemulsion-based assembly lanthanide luminescent nanocrystals and superparamagnetic iron oxide nanoparticles. We show that within provide temperature-sensitive luminescence lifetime depth-sensitive intensity ratio second near-infrared biological window (NIR-II), enabling accurate 3D thermographic mapping tissues uncertainty as low 0.12 °C. Meanwhile, nanoparticles facilitate targeted accumulation lesions under oriented magnetic field act heating sources oscillating fields without interfering measurements nanothermometers. With spatiotemporally synchronized imaging, we achieved efficient, programmed, noninvasive mice through controlled mild by adjusting direction strength applied field. Our proof-of-concept results suggest this nanoplatform is promising for high accuracy

Language: Английский

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Synchronously Manipulating the D−A Interaction and Planarity in Semiconducting Polymers to Achieve 84.7% Photothermal Conversion Efficiency for NIR‐II Imaging‐Guided Tumor Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: July 18, 2024

Abstract Exploiting photothermal agents with second‐near‐infrared (NIR‐II, 1000−1700 nm) emission and a high conversion efficiency (PCE) is an appealing challenging task. Herein, by simultaneously tailoring the D−A interaction planarity in fluorophores, two donor‐acceptor (D−A) −type semiconducting polymers (SPs), T‐BTP B‐BTP, are constructed. Compared T‐BTP, B‐BTP shows increased intramolecular interactions improved molecular planarity, leading to bathochromic‐shift absorption, NIR‐II emission, PCE. Notably, NPs achieve remarkable PCE of 84.7%, which among highest PCEs SPs fluorescence imaging‐guided therapy (PTT). Because these promising features, successfully used vascular imaging cancer therapy. This study provides valuable guidelines for development high‐performance SPs.

Language: Английский

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Copper-based hollow mesoporous nanogenerator with reactive oxygen species and reactive nitrogen species storm generation for self-augmented immunogenic cell death-mediated triple-negative breast cancer immunotherapy

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 688, P. 688 - 702

Published: Feb. 27, 2025

Language: Английский

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Near-Infrared Nanothermometer Reveals Temperature Discrepancy between Organs and Body Surface for Heatstroke Prevention

Nano Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Organ temperatures often vary significantly from body surface during heatstroke, leading to acute organ failure, although temperature is continuously controlled. However, the exact discrepancy between them remains unclear due a lack of noninvasive techniques for real-time monitoring fluctuations. Herein, we developed near-infrared emissive nanothermometer by codoping Nd3+ and Yb3+ produce two distinct emissions at 980 1330 nm under 808 excitation. These demonstrated differential responses variations, enabling construction ratiometric nanoprobe accurate detection. Notably, rapidly accumulated in mouse liver after intravenous injection, revealing that showed consistently higher than rectum approximately 1.5 °C. Moreover, injury was found begin rectal 42 °C, rather 43 °C conventionally used heatstroke models. findings introduce robust accurately understanding pathological progression heat-related illnesses.

Language: Английский

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Smart fluorogenic tools: From designing principles to visualization of multistep protein aggregation

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 535, P. 216625 - 216625

Published: March 19, 2025

Language: Английский

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Hierarchical Targeting Nanoplatform for NIR‐II Photoacoustic Imaging and Photo‐Activated Synergistic Immunotherapy of Glioblastoma

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Glioblastoma (GBM) stands as the most aggressive malignant brain tumor, characterized by poor prognosis, high recurrence rate, and resistance to multiple therapies, posing a significant clinical challenge. Here, hierarchical targeting platform is presented for NIR‐II photoacoustic (PA) imaging‐guided photo‐chemo synergistic immunotherapy of GBM. A new molecular probe developed with exceptional light‐harvesting capabilities enhanced motion, boosting both photothermal conversion PA signal. This probe, combined thermo‐responsive prodrug, assembled into nanoparticles that are further camouflaged tumor cell membranes bioorthogonally modified transferrin‐mimicking peptide, facilitating blood‐brain barrier penetration GBM targeting. High‐contrast imaging allows precise detection delineation GBM, providing accurate guidance subsequent treatment. The light‐triggered effect, coupled hyperthermia‐activated significantly induces immunogenic death, enhancing tumor‐killing efficiency amplifying anti‐tumor immune response. self‐synergistic not only stimulates robust immunity inhibits primary growth but also prevents post‐surgical recurrence, prolonging survival time. work exemplifies novel paradigm tackling diagnostic therapeutic challenges posed deeply seated poorly tumors.

Language: Английский

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Polydopamine-Encapsulated Cyanine Dye Nanoplatform for Near-Infrared Fluorescence Imaging-Guided Photothermal Therapy of Hepatocellular Carcinoma

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Language: Английский

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Intratumoral self-assembly of renal-clearable gold nanoparticles as precise photothermal nanomedicine for liver tumor therapy

Science Advances, Journal Year: 2025, Volume and Issue: 11(17)

Published: April 23, 2025

Noninvasive photothermal therapy (PTT) for cancer with agents (PTAs) has recently achieved success in both preclinical and clinical trials. However, traditional PTAs tend to nonspecifically accumulate normal liver tissue, hampering their use PTT of tumors. By taking advantage extremely low accumulation from ultrasmall renal-clearable gold nanoparticles (AuNPs), we report a biosafe therapeutic strategy treat tumors precisely through the intratumoral self-assembly AuNPs at tumor site via host-guest interactions. After active targeting host functionalized cyclo (Arg-Gly-Asp- d -Phe-Cys) cyclodextrin, guest pH-responsive doxorubicin adamantane are designed trigger self-assembly, enhancing chemotherapy toward microenvironment. This smart design principle generates precise action without causing any noticeable heating effect or damage surrounding tissue.

Language: Английский

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Tumor Pro-Senescence Strategy to Enhance Mild Photothermal Therapy of Diffuse Large B-Cell Lymphoma

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: May 22, 2025

Diffuse large B-cell lymphoma (DLBCL) presents a substantial clinical challenge due to its aggressive nature and resistance conventional therapies, thereby developing novel treatment strategies is critical. In this work, we take advantage of the insensitivity heat shock protein (HSP) expression in senescent tumor cells combine mild photothermal therapy (MPTT) for efficient DLBCL treatment. Insensitivity HSPs implies that are less capable activating their usual stress protection mechanisms during MPTT, which reduces tolerance damage. Consequently, can more effectively destroy target at lower temperatures while minimizing risk thermal injury surrounding healthy tissues. Abemaciclib inhibit CDK4/6 activity, inhibiting Rb phosphorylation suppress activity E2F transcription factor prevent transition from G1 S phase, leading cell cycle arrest ultimately cellular senescence. The experimental results indicated abemaciclib promoted senescence cells, accompanied by significant reduction HSP70 expression. Subsequently, near-infrared (NIR) absorbing organic polymer agent (PYIT-OD) with excellent optical properties photostability was used MPTT. integration pro-senescence as evidenced both vitro vivo outcomes, markedly enhanced efficacy, reducing damage normal tissues enhancing antitumor effects. This work not only reveals potential biological but also provides theoretical foundations practical guidance precise toxic regimens practice.

Language: Английский

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