Leukocyte-based delivery systems for enhanced nanotheranostics of inflammation and cancer DOI
Helin Li,

Fangyin Song,

Yu Chu

et al.

Nanotechnology, Journal Year: 2024, Volume and Issue: 35(48), P. 482501 - 482501

Published: Aug. 15, 2024

Abstract As a part of the immune system, leukocytes (LEs) have features circumvention immunogenicity as well recruitment to sites inflammation during infection and tumorigenesis. Utilizing LEs vehicles carry theranostic agents is promising strategy for highly efficient targeted delivery treatment cancer. Specifically, LEs, similar ‘Trojan horses’, can bypass system thus enhance therapeutic effects on In this context, latest progress LEs-based systems improving theranostics inflammations cancers summarized, including in vitro incubation vivo internalization strategy. Although efficacy has been achieved, construction complex effect not fulfilling demand completely. Encouragingly, most recent work reported that supramolecular arrangement proteins nanocarriers would drive them be selectively uptaken by neutrophils, opening new avenue diagnosis inflammation. Moreover, enucleated cells are considered biomimetic drug vehicle retain organelles range diseases safe, controllable effective manner. These novel findings provide more opportunities researchers rethink redesign overcome existing limitations broaden their usage, especially clinical medicine.

Language: Английский

Decoding the “Fingerprint” of Implant Materials: Insights into the Foreign Body Reaction DOI
Yangmengfan Chen,

Zeyu Luo,

Weikun Meng

et al.

Small, Journal Year: 2024, Volume and Issue: 20(23)

Published: Jan. 8, 2024

Abstract Foreign body reaction (FBR) is a prevalent yet often overlooked pathological phenomenon, particularly within the field of biomedical implantation. The presence FBR poses heavy burden on both medical and socioeconomic systems. This review seeks to elucidate protein “fingerprint” implant materials, which generated by physiochemical properties materials themselves. In this review, activity macrophages, formation foreign giant cells (FBGCs), development fibrosis capsules in context are introduced. Additionally, relationship between various elucidated detail, as an overview existing approaches technologies employed alleviate FBR. Finally, significance components (metallic non‐metallic materials), surface CHEMISTRY (charge wettability), physical characteristics (topography, roughness, stiffness) establishing also well documented. conclusion, aims emphasize importance provides current perspectives developing with anti‐FBR properties.

Language: Английский

Citations

20
Regulated cell death‐amplified sonodynamic anti‐tumor immune nanotherapeutics DOI Creative Commons
Liqiang Zhou, Yangmengfan Chen, Dong Xie

et al.

BMEMat, Journal Year: 2024, Volume and Issue: unknown

Published: March 4, 2024

Abstract Nanomedicine‐assisted sonodynamic therapy (SDT) has emerged as one of the most promising cancer therapies due to its unique advantages high penetration, non‐radiation, and excellent oxidative stress effect, but always suffered from self‐protection mechanism apoptosis resistance characteristics evolutionarily mutated cells. Regulated cell death (RCD) received increasing attention in precision treatments because significant role synergistically sensitizing reversing immunosuppressive microenvironment during SDT nanomedicine‐triggered immunogenic death. Herein, paradigmatic research RCD‐augmented tumor immunotherapeutics are typically introduced, such autophagy blockade, ferroptosis targeting, pyroptosis induction, necroptosis initiation, cuproptosis actuation, PANoptosis trigger, coordinated anti‐tumor mechanisms discussed detail. Multiple analysis focusing on currently unsolved problems future development prospects RCD‐based nano‐oncology medicine also prospected further strengthen expand scope therapeutic applications.

Language: Английский

Citations

20
Magnetically driven bionic nanorobots enhance chemotherapeutic efficacy and the tumor immune response via precise targeting DOI Creative Commons
Zhijie Wang, Chutian Wang, Ying Ji

et al.

The Innovation, Journal Year: 2025, Volume and Issue: 6(2), P. 100777 - 100777

Published: Jan. 18, 2025

We developed magnetically driven bionic drug-loaded nanorobots (MDNs) to accurately target tumors and deliver chemotherapy agents using a customized three-dimensional (3D) magnetic manipulation platform (MMP) system precisely control their movement mode. MDNs were based on polyethylene glycol-modified homogeneous ultrasmall iron oxide nanoparticles (7.02 ± 0.18 nm). Doxorubicin (12% 2% [w/w]) was encapsulated in by an imide bond. could imitate the mode of school wild herrings (e.g., re-dispersion/arrangement/vortex/directional movement) adapt changing complex physiological environment through 3D MMP system. overcame blood flow resistance biological barriers optimized driving properties according vivo imaging (magnetic resonance fluorescence) histopathology. The performance fabricated verified cells tumor-bearing mouse models. showed high efficiency drug delivery targeting at tumor site (>10-fold), lower toxicity than free doxorubicin (5 mg/kg body weight), activated immune response site, significantly lengthened survival for mice. synergistic interaction between underscores immense potential this system, indicating revolution field chemotherapy.

Language: Английский

Citations

3
Apoptosis‐Sensitizing Tumor Nanomedicine by Regulating Pyroptosis‐Associated Inflammatory Cell Death DOI

Fangxue Du,

Hongxin Zhao,

Yangmeihui Song

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: May 25, 2024

Abstract The vigorous development of cancer nanomedicine has revolutionized traditional oncology medicine, but it is also limited by the continuous mutation cunning cells, leading to apoptosis insensitivity and therapeutic disappointment. Inflammatory‐regulated cell death (RCD), especially pyroptosis‐related death, demonstrates huge potential for sensitization due its unique biochemical characteristics. aim this research present a thorough synopsis current knowledge on pyroptosis‐associated inflammatory including pyroptosis, cuproptosis, PANoptosis, synergistic function in nano therapy. Paradigm studies death‐mediated apoptosis‐sensitizing tumor nanotherapeutics are introduced detail, coordination mechanisms based nanomaterials discussed. In addition, multi‐angle analysis future prospects pyroptosis‐sensitized various emphasized further expand application scope RCD. It believed that emerging auxiliary treatments RCD will greatly promote progress nanomedicine.

Language: Английский

Citations

10
Magnetic Micro/nanorobots in Cancer Theranostics: From Designed Fabrication to Diverse Applications DOI
Lin Zhang, Shuren Wang, Yanglong Hou

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Cancer poses a substantial threat and serious challenge to public human health, driving the promotion of sophisticated technologies for cancer therapy. While conventional chemotherapy has bottlenecks such as low delivery efficiency, strong toxic side effects, tumor enrichment barriers, magnetic micro/nanorobots (MNRs) emerge promising therapeutic candidates that provide alternative strategies MNR is kind human-made machine micro- or nanosized, reasonably designed, performs command tasks through self-actuated externally controlled propulsion mechanisms, which can be potentially applied in theranostics. Here, this review first introduces components constitute typical MNR, including body part, control function sensing part. Subsequently, elucidates representative fabrication methods construct MNRs from top-down approaches bottom-up approaches, covering injection molding, self-rolling, melt electrospinning writing, deposition, biotemplate method, lithography, assembling, 3D printing, chemical synthesis. Furthermore, focuses on multiple applications facing diagnosis treatment, encompassing imaging, quantification, drug release, synergy with therapies, cell manipulation, surgical assistance. Then, systematically elaborates biocompatibility biosafety MNRs. Finally, challenges faced by are discussed alongside future research directions. This intended scientific guidance may improve comprehension cognition theranostics platform MNRs, promoting prospering practical application development

Language: Английский

Citations

1
Normal weight obesity is associated with lower AFC and adverse IVF outcomes DOI Creative Commons
Yangcheng Yao, Wenjuan Liu,

Xiqian Zhang

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 22, 2024

Body weight could be classified into underweight, normal and overweight according to percentage of body fat (%BF), obesity (NWO) is defined as a BMI but high %BF. While the impact NWO in women fecundity remain unknow. Therefore, this study aimed investigate associations between %BF reproductive outcomes among

Language: Английский

Citations

5
Thermoelectric Nanoheterojunction-Mediated Multiple Energy Conversion for Enhanced Cancer Therapy DOI
Yanlin Zhu, Qingzhen Hao,

Haixia Zhu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Electron-hole recombination and exogenous local hypoxia both impede the effectiveness of thermoelectric tumor catalytic therapy. Here, a heterojunction (Pt-TiO

Language: Английский

Citations

5
Artificial molecular motors in biological applications DOI Creative Commons

Frank Fan,

Shengqiu Liu, Yuting Yan

et al.

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 8, 2025

Molecular motors are the cornerstone for maintenance of living systems and mediate almost all fundamental processes involved in cellular trafficking. The intricate mechanisms underlying natural molecular have been elucidated detail, inspiring researchers various fields to construct artificial with multi-domain applications. This review summarises characteristics motors, biomimetic approaches their design operation, recent biological

Language: Английский

Citations

0
Recent Progress in DNA Biosensors for Detecting Biomarkers in Living Cells DOI
Zaizai Dong,

Rongtai Su,

Yao Fu

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(9), P. 5595 - 5608

Published: Aug. 15, 2024

Analysis of biomarkers in living cells is crucial for deciphering the dynamics as well precise diagnosis diseases. DNA biosensors employ sequences probes to offer insights into cells, and drive progress disease drug development. In this review, we present recent advances detecting cells. The basic structural components signal output method are presented. strategies crossing cell membrane also described, including coincubation, nanocarriers, nanoelectroporation techniques. Based on biomarker categorization, detail applications small molecules, RNAs, proteins, integrated targets Furthermore, future development directions summarized encourage further research growing field.

Language: Английский

Citations

3
Leukocyte-based delivery systems for enhanced nanotheranostics of inflammation and cancer DOI
Helin Li,

Fangyin Song,

Yu Chu

et al.

Nanotechnology, Journal Year: 2024, Volume and Issue: 35(48), P. 482501 - 482501

Published: Aug. 15, 2024

Abstract As a part of the immune system, leukocytes (LEs) have features circumvention immunogenicity as well recruitment to sites inflammation during infection and tumorigenesis. Utilizing LEs vehicles carry theranostic agents is promising strategy for highly efficient targeted delivery treatment cancer. Specifically, LEs, similar ‘Trojan horses’, can bypass system thus enhance therapeutic effects on In this context, latest progress LEs-based systems improving theranostics inflammations cancers summarized, including in vitro incubation vivo internalization strategy. Although efficacy has been achieved, construction complex effect not fulfilling demand completely. Encouragingly, most recent work reported that supramolecular arrangement proteins nanocarriers would drive them be selectively uptaken by neutrophils, opening new avenue diagnosis inflammation. Moreover, enucleated cells are considered biomimetic drug vehicle retain organelles range diseases safe, controllable effective manner. These novel findings provide more opportunities researchers rethink redesign overcome existing limitations broaden their usage, especially clinical medicine.

Language: Английский

Citations

1