Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
Abstract
In
the
field
of
bioadhesives,
development
machinable
adhesives
with
a
“glue‐to‐gel
transition”
remains
significant
challenge.
This
study
presents
novel
design
strategy
to
endow
Gel/Eg
adhesive
mechanical
machinability.
It
leverages
combination
hydrogen
bond
interactions,
metal
complexation,
and
secondary
structure
gelatin
through
one‐step
mixing
method.
Rheological
analysis
shows
that
exhibits
frequency‐dependent
transition,”
maintaining
glue
state
at
low
frequencies
transitioning
gel
higher
frequencies.
During
stretching,
β‐sheet
transforms
into
random
coil
structure.
Moreover,
features
excellent
water
resistance,
swelling
ratio,
strong
adhesion
strength,
high
extensibility,
instantaneous
adhesion,
self‐healing,
both
biocompatibility
hemocompatibility.
These
attributes
enable
exhibit
multiple
fault‐tolerance
capabilities
on
tissue
surfaces,
highlighting
its
potential
for
diverse
biomedical
applications.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
38, P. 1 - 30
Published: April 23, 2024
Characterized
by
their
pivotal
roles
in
cell-to-cell
communication,
cell
proliferation,
and
immune
regulation
during
tissue
repair,
exosomes
have
emerged
as
a
promising
avenue
for
"cell-free
therapy"
clinical
applications.
Hydrogels,
possessing
commendable
biocompatibility,
degradability,
adjustability,
physical
properties
akin
to
biological
tissues,
also
found
extensive
utility
engineering
regenerative
repair.
The
synergistic
combination
of
hydrogels
holds
the
potential
not
only
enhance
efficiency
but
collaboratively
advance
repair
process.
This
review
has
summarized
advancements
made
over
past
decade
research
hydrogel-exosome
systems
regenerating
various
tissues
including
skin,
bone,
cartilage,
nerves
tendons,
with
focus
on
methods
encapsulating
releasing
within
hydrogels.
It
critically
examined
gaps
limitations
current
research,
whilst
proposed
future
directions
applications
this
innovative
approach.
Gels,
Journal Year:
2024,
Volume and Issue:
10(9), P. 547 - 547
Published: Aug. 23, 2024
Regenerative
hydrogels
from
natural
polymers
have
come
forth
as
auspicious
materials
for
use
in
regenerative
medicine,
with
interest
attributed
to
their
intrinsic
biodegradability,
biocompatibility,
and
ability
reassemble
the
extracellular
matrix.
This
review
covers
latest
advances
used
wound
healing,
focusing
on
chemical
composition,
cross-linking
mechanisms,
functional
properties.
Key
carbohydrate
polymers,
including
alginate,
chitosan,
hyaluronic
acid,
polysaccharide
gums,
agarose,
carrageenan,
xanthan
gum,
are
discussed
terms
of
sources,
structures
specific
properties
suitable
applications.
The
further
explores
categorization
based
ionic
charge,
response
physiological
stimuli
(i.e.,
pH,
temperature)
particularized
roles
tissue
self-healing.
Various
methods
enhance
mechanical
biological
performance
these
also
examined.
By
highlighting
recent
innovations
ongoing
challenges,
this
article
intends
give
a
detailed
understanding
potential
revolutionize
medicine
improve
patient
healing
outcomes.
Angewandte Chemie International Edition,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 5, 2025
Abstract
Infectious
diseases
pose
considerable
challenges
to
public
health,
particularly
with
the
rise
of
multidrug‐resistant
pathogens
that
globally
cause
high
mortality
rates.
These
can
persist
on
surfaces
and
spread
in
healthcare
settings.
Advances
have
been
made
developing
antimicrobial
materials
reduce
transmission
pathogens,
including
composed
naturally
sourced
polyphenols
their
derivatives,
which
exhibit
potency,
broad‐spectrum
activity,
a
lower
likelihood
promoting
resistance.
This
review
provides
an
overview
recent
advances
fabrication
phenolic
biomaterials,
where
natural
compounds
act
as
active
agents
or
encapsulate
other
(e.g.,
metal
ions,
peptides,
biopolymers).
Various
forms
biomaterials
synthesized
through
these
two
strategies,
particles,
capsules,
hydrogels,
coatings,
are
summarized,
focus
application
wound
healing,
bone
repair
regeneration,
oral
coatings
for
medical
devices.
The
potential
advanced
promising
therapeutic
approach
combating
antimicrobial‐resistant
infections
reducing
microbial
transmission.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 29, 2024
Abstract
The
challenge
in
treating
diabetic
foot
infections
caused
by
drug‐resistant
bacteria
is
rapidly
eradicating
and
accelerating
wound
healing.
NIR‐II‐induced
photothermal
therapy
(PTT)
offers
notable
advantages
over
conventional
treatments,
such
as
broad‐spectrum
bactericidal
efficacy,
better
penetration
depth
biological
tissues,
higher
skin
tolerance
thresholds,
making
it
particularly
suitable
for
addressing
infections.
Herein,
found
that
NIR‐II
dye
IR26
exhibited
good
effects
but
poor
stability.
By
modifying
with
methoxy
triphenylamine
groups,
a
novel
D–A–D‐type
small
molecule
agent
(IRC)
developed,
high
stability
conversion
efficiency
(44.3%).
IRC
maximum
absorption
wavelength
of
1166
nm
emission
1238
nm.
However,
PTT
alone
cannot
effectively
promote
Therefore,
nanoplatforms
(Cur‐IRC@PCM)
are
developed
coloading
curcumin,
natural
wound–healing
compound,
into
thermosensitive
liposomes
to
treat
MRSA‐infected
wounds.
Under
980
laser
irradiation,
Cur‐IRC@PCM
provided
controlled
the
precise
release
synergizing
eradicate
accelerate
closure.
intelligent
antibacterial
also
exhibits
excellent
biocompatibility,
rendering
promising
therapeutic
tool
biomedical
fields
combating
bacterial
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(40), P. 10163 - 10197
Published: Jan. 1, 2024
Diabetic
wounds
pose
a
significant
challenge
in
healthcare
due
to
impaired
healing
and
increased
risk
of
complications.
In
recent
years,
various
drug
delivery
systems
with
stimuli-responsive
features
have
been
developed
address
these
issues.
These
enable
precise
dosage
control
tailored
release,
promoting
comprehensive
tissue
repair
regeneration.
This
review
explores
targeted
therapeutic
agents,
such
as
carboxymethyl
chitosan-alginate
hydrogel
formulations,
nanofiber
mats,
core-shell
nanostructures,
for
diabetic
wound
healing.
Additionally,
the
integration
nanotechnology
multifunctional
biomimetic
scaffolds
shows
promise
enhancing
outcomes.
Future
research
should
focus
on
optimizing
design,
materials,
printing
parameters
3D-bio-printed
dressings,
well
exploring
combined
strategies
involving
simultaneous
release
antibiotics
nitric
oxide
improved
