Hydrogel-exosome system in tissue engineering: A promising therapeutic strategy

Bioactive Materials, Journal Year: 2024, Volume and Issue: 38, P. 1 - 30

Published: April 23, 2024

Characterized by their pivotal roles in cell-to-cell communication, cell proliferation, and immune regulation during tissue repair, exosomes have emerged as a promising avenue for "cell-free therapy" clinical applications. Hydrogels, possessing commendable biocompatibility, degradability, adjustability, physical properties akin to biological tissues, also found extensive utility engineering regenerative repair. The synergistic combination of hydrogels holds the potential not only enhance efficiency but collaboratively advance repair process. This review has summarized advancements made over past decade research hydrogel-exosome systems regenerating various tissues including skin, bone, cartilage, nerves tendons, with focus on methods encapsulating releasing within hydrogels. It critically examined gaps limitations current research, whilst proposed future directions applications this innovative approach.

Language: Английский

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Trends in polysaccharide-based hydrogels and their role in enhancing the bioavailability and bioactivity of phytocompounds

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 334, P. 122033 - 122033

Published: March 11, 2024

Language: Английский

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Natural Regenerative Hydrogels for Wound Healing

Gels, Journal Year: 2024, Volume and Issue: 10(9), P. 547 - 547

Published: Aug. 23, 2024

Regenerative hydrogels from natural polymers have come forth as auspicious materials for use in regenerative medicine, with interest attributed to their intrinsic biodegradability, biocompatibility, and ability reassemble the extracellular matrix. This review covers latest advances used wound healing, focusing on chemical composition, cross-linking mechanisms, functional properties. Key carbohydrate polymers, including alginate, chitosan, hyaluronic acid, polysaccharide gums, agarose, carrageenan, xanthan gum, are discussed terms of sources, structures specific properties suitable applications. The further explores categorization based ionic charge, response physiological stimuli (i.e., pH, temperature) particularized roles tissue self-healing. Various methods enhance mechanical biological performance these also examined. By highlighting recent innovations ongoing challenges, this article intends give a detailed understanding potential revolutionize medicine improve patient healing outcomes.

Language: Английский

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Antimicrobial Phenolic Materials: From Assembly to Function

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug‐resistant pathogens that globally cause high mortality rates. These can persist on surfaces and spread in healthcare settings. Advances have been made developing antimicrobial materials reduce transmission pathogens, including composed naturally sourced polyphenols their derivatives, which exhibit potency, broad‐spectrum activity, a lower likelihood promoting resistance. This review provides an overview recent advances fabrication phenolic biomaterials, where natural compounds act as active agents or encapsulate other (e.g., metal ions, peptides, biopolymers). Various forms biomaterials synthesized through these two strategies, particles, capsules, hydrogels, coatings, are summarized, focus application wound healing, bone repair regeneration, oral coatings for medical devices. The potential advanced promising therapeutic approach combating antimicrobial‐resistant infections reducing microbial transmission.

Language: Английский

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Advances in natural polymer-based hydrogels: synthesis, applications, and future directions in biomedical and environmental fields

Discover Polymers., Journal Year: 2025, Volume and Issue: 2(1)

Published: March 20, 2025

Language: Английский

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Konjac glucomannan/zein active film loaded with tea polyphenol–ferric nanoparticles for strawberry preservation

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 139905 - 139905

Published: Jan. 19, 2025

Language: Английский

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Development of D–A–D‐Type NIR‐II Photothermal Agents for Synergistic Eradication of Multidrug‐Resistant Bacteria and Promoting Diabetic Wound Healing

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 29, 2024

Abstract The challenge in treating diabetic foot infections caused by drug‐resistant bacteria is rapidly eradicating and accelerating wound healing. NIR‐II‐induced photothermal therapy (PTT) offers notable advantages over conventional treatments, such as broad‐spectrum bactericidal efficacy, better penetration depth biological tissues, higher skin tolerance thresholds, making it particularly suitable for addressing infections. Herein, found that NIR‐II dye IR26 exhibited good effects but poor stability. By modifying with methoxy triphenylamine groups, a novel D–A–D‐type small molecule agent (IRC) developed, high stability conversion efficiency (44.3%). IRC maximum absorption wavelength of 1166 nm emission 1238 nm. However, PTT alone cannot effectively promote Therefore, nanoplatforms (Cur‐IRC@PCM) are developed coloading curcumin, natural wound–healing compound, into thermosensitive liposomes to treat MRSA‐infected wounds. Under 980 laser irradiation, Cur‐IRC@PCM provided controlled the precise release synergizing eradicate accelerate closure. intelligent antibacterial also exhibits excellent biocompatibility, rendering promising therapeutic tool biomedical fields combating bacterial

Language: Английский

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Alginate-based hydrogels mediated biomedical applications: A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 279, P. 135019 - 135019

Published: Aug. 28, 2024

Language: Английский

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Wound microenvironment sensing and self-adjusting hydrogel with glucose, ROS, and MMP-9 responsiveness for improving microcirculation of diabetes foot ulcers

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159537 - 159537

Published: Jan. 1, 2025

Language: Английский

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Recent advances in sodium alginate-based dressings for targeted drug delivery in the context of diabetic wound healing

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(40), P. 10163 - 10197

Published: Jan. 1, 2024

Diabetic wounds pose a significant challenge in healthcare due to impaired healing and increased risk of complications. In recent years, various drug delivery systems with stimuli-responsive features have been developed address these issues. These enable precise dosage control tailored release, promoting comprehensive tissue repair regeneration. This review explores targeted therapeutic agents, such as carboxymethyl chitosan-alginate hydrogel formulations, nanofiber mats, core-shell nanostructures, for diabetic wound healing. Additionally, the integration nanotechnology multifunctional biomimetic scaffolds shows promise enhancing outcomes. Future research should focus on optimizing design, materials, printing parameters 3D-bio-printed dressings, well exploring combined strategies involving simultaneous release antibiotics nitric oxide improved

Language: Английский

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