Multifunctional nanofiber system with photothermal-controlled drug delivery and motion monitoring capabilities as intelligent wound dressing DOI

Peiran Lin,

K. K. He,

Jiahui Luo

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158544 - 158544

Published: Dec. 11, 2024

Language: Английский

Dendritic donor engineering to optimize second near-infrared photothermal agents for in situ photothermal therapy DOI
Jialin Tong,

Xiaohan Xie,

Jing Gao

et al.

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 689, P. 137190 - 137190

Published: March 7, 2025

Language: Английский

Citations

0
A Near-Infrared Responsive Hydrogel Loaded with Prussian Blue-Based Nanocarriers for Co Gas Therapy of Infected Wounds DOI
Yao Li,

Zhixue Zhang,

Haoran Jiang

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Visible light-activated Ti-MOF loaded metformin-hydrogel composite dressing for accelerated chronic diabetic wound healing DOI
Meng Tian,

Chuan Fan,

Rujiao Ge

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 506, P. 160179 - 160179

Published: Jan. 1, 2025

Language: Английский

Citations

0
A flexible multifunctional sensor with a conductive network based on silk nanofibers and MXene for monitoring physiological activity, capacitive pens, photothermal conversion and antibacterial DOI

Chen-Man Zong,

Bei Zhang, Siying Li

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 305, P. 141148 - 141148

Published: Feb. 17, 2025

Language: Английский

Citations

0
Near‐Infrared Multiple‐Resonance Polycyclic Aromatic Hydrocarbon as Type I Photosensitizer Toward High‐Performance Synergistic Phototherapy DOI
Yulong Shi, Wei Yang, He Zhang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Abstract Type I photosensitization is of particular significance in the anaerobic tumor treatment. Nonetheless, development high‐performance type photosensitizers (PSs) remains challenging, due to weak absorption and inefficient intersystem crossing (ISC) progress. Herein, an effective approach toward a near‐infrared (NIR) PS ( NIR‐BN ) demonstrated using boron/nitrogen‐embedded polycyclic aromatic hydrocarbon with multiple‐resonance (MR) character, for first time. A small singlet‐triplet splitting (Δ E ST = 0.09 eV) high molar extinction coefficient (3.3 × 10 4 M −1 cm NIR MR‐configured supports efficient ISC triplet sensitization. The distorted molecular configurations induce multi‐model structural relaxations after optical excitation, resulting remarkable photothermal conversion efficiency exceeding 50% nanoparticles. Of note, nanoparticles are capable generating highly toxic superoxide anion radical (O 2 •− under 660 nm laser irradiation, benefiting from vigorous intramolecular dihedral angle vibrations excited states. Consequently, biocompatible demonstrates superior performance vivo synergistic photodynamic therapies.

Language: Английский

Citations

0
Near-infrared light-triggered in situ self-assembly nanomedicine for treating antibiotic-resistant bacterial infection DOI
Yu Zhang,

Chunhua Ren,

Huayang Liu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161303 - 161303

Published: March 1, 2025

Language: Английский

Citations

0
SERS-based approaches in the investigation of bacterial metabolism, antibiotic resistance, and species identification DOI
Zhihong Nie, Zhijun Huang,

Zhongying Wu

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2025, Volume and Issue: 336, P. 126051 - 126051

Published: March 13, 2025

Language: Английский

Citations

0
A Single H2S-Releasing Nanozyme for Comprehensive Diabetic Wound Healing through Multistep Intervention DOI
Ying Yin, Wentai Guo,

Q Y Chen

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

Diabetic wound healing presents a significant medical challenge and requires multistep interventions due to comprehensive environments, such as hyperglycemia, bacterial infection, impaired angiogenesis. However, current are complicated need on-demand sequential release synergy of multicomponents. Herein, H2S-releasing cascade nanozyme (FeS@Au), which is composed ultrasmall gold nanocluster (AuNC) loaded on ferrous sulfide nanoparticle (FeSNP), developed single component regulate glucose level, eliminate promote angiogenesis, achieving for diabetic treatment. The oxidase-like activity AuNC catalyzes into gluconic acid H2O2, not only lowers the local level but also decreases pH increases H2O2 boost peroxidase-like FeSNP generate abundant hydroxyl radical (reactive oxygen species, ROS), inducing ferroptosis-like death in drug-resistant bacteria. Additionally, H2S acidified environment upregulate hypoxia-inducible factor-1 enhance vascularization through upregulating expression vascular endothelial growth factor (VEGF) other angiogenesis-related genes, reducing damage cells caused by excessive ROS produced nanozyme. In full-thickness MRSA-infected rat model, FeS@Au significantly eliminates bacteria, enhances promotes collagen deposition, accelerates healing. This work with H2S-release interventions, providing versatile strategy extensive tissue diabetes.

Language: Английский

Citations

0
Development of a Highly Efficient NIR-II Phototherapeutic Agent for Fluorescence Imaging-Guided Synergistic PTT/PDT/Chemotherapy of Colorectal Cancer DOI
Ji Liu, Lei Liang,

Ping Gan

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

NIR-II-triggered phototherapy presents a noninvasive, resistance-free alternative therapeutic approach with deeper tissue penetration and improved imaging of deep tumors. However, many NIR-II phototherapeutic agents suffer from low fluorescence quantum yields, poor photothermal conversion efficiency (PCE), reduced efficacy due to the upregulation heat shock protein HSP70. This study develops small-molecule agent (IRF) high yield (17.4%), excellent PCE (96.8%) for therapy (PTT), photodynamic (PDT) activity. To decrease thermal resistance during phototherapy, IRF evodiamine (EVO) were loaded onto hyaluronic acid (HA)-modified nanoparticles, creating multifunctional nanoplatform termed EVO/IRF@HA NPs. NPs can actively target tumors via HA moiety. Upon 980 nm laser irradiation, increases temperature content reactive oxygen species synergistic PTT/PDT. Importantly, EVO effectively inhibits overexpression HSP70, enabling combined PTT/PDT/chemotherapy effective colorectal cancer (CRC) treatment.

Language: Английский

Citations

0
A near-infrared responsive hydrogel loaded with Prussian blue-based nanocarriers for CO gas therapy of infected wounds DOI
Yao Li,

Zhixue Zhang,

Haoran Jiang

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162544 - 162544

Published: April 1, 2025

Language: Английский

Citations

0