Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
12
Published: Dec. 20, 2024
Abstract
During
the
implantation
process
of
cardiovascular
implants,
vascular
damage
caused
by
inflammation
occurs,
and
inflammatory
is
accompanied
oxidative
stress.
Currently,
carbon
monoxide
(CO)
has
been
demonstrated
to
exhibit
various
biological
effects
including
vasodilatation,
antithrombotic,
anti-inflammatory,
apoptosis-inducing
antiproliferative
properties.
In
this
study,
hemoglobin/epigallocatechin-3-gallate
(EGCG)
core-shell
nanoparticle-containing
coating
on
stainless
steel
was
prepared
for
CO
loading
modulation.
Inspired
strong
coordination
ability
with
CO,
hemoglobin
nanoparticle
first
encapsulated
into
EGCG
metal-phenolic
networks.
A
polydopamine
(PDA)
linking
layer
then
coated
316
steel,
hemoglobin/EGCG
nanoparticles
were
loaded
subsequent
PDA
deposition.
It
showed
that
maximum
release
amount
17.0
nmol/cm2
in
48
h.
vitro
evaluations
conducted
a
simulated
environment
revealed
coating,
which
released
from
nanoparticles,
effectively
mitigated
lipopolysaccharide-induced
response
macrophages.
Specifically,
it
decreased
expression
tumor
necrosis
factor-α,
increased
interleukin-10,
suppressed
polarization
macrophages
toward
M1
phenotype
reduced
intracellular
reactive
oxygen
species
(ROS).
Furthermore,
under
stress
conditions,
apoptosis
endothelial
cells
induced
down-regulated
ROS
levels.
vivo
results
further
confirmed
its
capabilities,
macrophage-mediated
responses
modulated
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(8), P. 4086 - 4153
Published: Jan. 1, 2024
This
review
critically
analyzes
degradable
biomedical
elastomers,
focusing
on
their
degradation,
synthesis,
microstructure,
and
role
in
tissue
repair.
It
guides
experts
balancing
degradation
with
repair
for
improved
applications.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 24, 2025
Cell
membrane
coating
has
emerged
as
a
promising
strategy
for
the
surface
modification
of
biomaterials
with
biological
membranes,
serving
cloak
that
can
carry
more
functions.
The
cloaked
inherit
diverse
intrinsic
biofunctions
derived
from
different
cell
sources,
including
enhanced
biocompatibility,
immunity
evasion,
specific
targeting
capacity,
and
immune
regulation
regenerative
microenvironment.
characteristics
biomimicry
biointerfacing
have
demonstrated
versatility
technology
on
variety
biomaterials,
thus,
furthering
research
into
wide
range
biomedical
applications
clinical
translation.
Here,
preparation
coatings
is
emphasized,
sizes
coated
nanoscale
to
macroscale
well
engineering
strategies
introduce
additional
are
summarized.
Subsequently,
utilization
biomimetic
membrane-cloaked
in
discussed,
drug
delivery,
imaging
phototherapy,
cancer
immunotherapy,
anti-infection
detoxification,
implant
modification.
In
conclusion,
latest
advancements
preclinical
studies,
along
multiple
benefits
membrane-coated
nanoparticles
(NPs)
systems,
elucidated.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 10, 2025
Skin
burn
wounds
(SBWs)
are
common
clinical
injuries
due
to
excessive
exposure
factors
including
heat,
radiation,
chemical
agents,
etc.
However,
the
efficient
healing
of
SBWs
is
still
challenging
persistent
inflammation
and
high
risk
local
infection.
To
meet
these
challenges,
we
report
a
hydrogel-based
bioactive
synthetic
skin
(HBSS)
from
biocompatible
components
as
dressing
materials
for
wound
treatment,
which
mediated
localized
H2S
release
stimulate
tissue
regeneration
while
preventing
bacterial
infection
inflammation.
Here,
donor
(N-(benzoyl
mercapto)
benzamide)
was
first
coassembled
with
thioketal
(TK)-ligated
dopamine
dimer
form
nanoscale
assemblies
(DDNs),
were
then
integrated
into
Schiff
base-cross-linked
hyaluronic
acid-carboxymethyl
chitosan
hydrogels.
The
elevated
acidity
in
would
trigger
hydrogel
degradation
DDNs,
further
activated
by
ROS-induced
cleavage
TK
linkers
gas
attenuating
ROS
stress
self-immolative
manner,
thus
promoting
angiogenesis
through
activating
AMPK
RAS-MAPK-AP1
prohealing
pathways,
enabling
M1-to-M2
macrophage
reprogramming
ERK1/2
NRF2
signaling.
Meanwhile,
network
could
inhibit
colonization
at
site
prevent
These
merits
acted
cooperative
manner
enable
accelerated
robust
healing,
offering
an
approach
treatment
clinic.
