Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 11, 2024
Rotator
cuff
injuries
often
necessitate
surgical
intervention,
but
the
outcomes
are
unsatisfactory.
The
underlying
reasons
can
be
attributed
to
multiple
factors,
with
intricate
inflammatory
activities
and
insufficient
presence
of
stem
cells
being
particularly
significant.
In
this
study,
an
innovative
inflammation-responsive
core-shell
micro-hydrogel
is
designed
for
independent
release
SDF-1
IL-4
within
a
single
delivery
system
promote
tendon-to-bone
healing
by
recruiting
MSCs
modulating
M2
macrophages
polarization.
First,
MMP-2
responsive
hydrogel
loaded
(GelMA-MMP/IL-4)
synthesized
cross-linking
gelatin
methacrylate
(GelMA)
substrate
peptide.
Then,
resulting
core
particles
coated
shell
chitosan
/SDF-1/hyaluronic
acid
(CS/HA/SDF-1)
using
layer-by-layer
electrostatic
deposition
method
form
composite.
shows
sustained
MMP-2-responsive
associated
in
situ
homing
smart
inflammation
regulation
promoting
Additionally,
injecting
these
micro-hydrogels
into
rat
rotator
tear
repair
model,
notable
improvements
fibrocartilage
layer
observed
between
tendon
bone.
Notably,
study
presents
new
potentially
powerful
environment-responsive
drug
strategy
that
offers
valuable
insights
regulating
micro-environment
tissue
regeneration.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
37(22)
Published: Jan. 13, 2025
Abstract
To
reduce
carbon
footprint
and
human
dependence
on
fossil
fuels,
the
field
of
bio‐based
polymers
has
undergone
explosive
growth
in
recent
years.
Among
them,
elastomers
have
gained
tremendous
attention
for
their
inherent
softness,
high
strain,
resilience.
In
this
review,
progress
representative
derived
from
molecular
building
blocks
biopolymers
are
recapitulated,
with
an
emphasis
design,
synthesis
approaches,
mechanical
performance.
The
performance‐advantaged
properties
elastomers,
including
immune
modulation,
biocompatibility,
biodegradability
also
explored.
Furthermore,
biomedical
applications
wound
dressing,
cardiovascular,
nerve
repair,
bone
biosensors
exemplified.
Lastly,
challenges
outlooks
development
discussed.
This
review
aims
to
offer
readers
valuable
insights
into
potential
as
viable
alternatives
petroleum‐based
counterparts,
supporting
transition
toward
a
more
sustainable
future.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: April 17, 2025
Clinically,
intraoperative
treatment
of
bone
tumors
presents
several
challenges,
including
the
effective
inactivation
and
filling
irregular
defects
after
tumor
removal.
In
this
study,
intelligent
thermosensitive
composite
materials
with
shape-memory
properties
were
constructed
using
polylactic
acid
(PLA)
polycaprolactone
(PCL),
which
have
excellent
biocompatibility
degradability.
Additionally,
beta-tricalcium
phosphate
(β-TCP),
its
osteogenic
properties,
magnesium
(Mg)
powder,
photothermal
bone-promoting
abilities,
incorporated
to
improve
potential
enable
material
respond
intelligently
near-infrared
(NIR)
light.
Utilizing
3D
printing
technology,
was
prepared
into
an
NIR-responsive
bone-filling
implant
that
deforms
when
scaffold
temperature
increases
48
℃
under
NIR
laser
irradiation.
Moreover,
at
a
lower
42
℃,
mild
therapy
promotes
macrophage
polarization
toward
M2
phenotype.
This
process
regulates
secretion
interleukin
(IL)-4,
IL-10,
necrosis
factor-α,
IL-6,
morphogenetic
protein
(BMP)-2,
reducing
local
inflammation,
enhancing
release
pro-healing
factors,
improving
osteogenesis.
Overall,
innovative
is
promising
efficient
for
surgery.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
26, P. 101098 - 101098
Published: May 22, 2024
Developing
patches
that
effectively
merge
intrinsic
deformation
characteristics
of
cardiac
with
superior
tunable
mechanical
properties
remains
a
crucial
biomedical
pursuit.
Currently
used
traditional
block-shaped
or
mesh
patches,
typically
incorporating
positive
Poisson's
ratio,
often
fall
short
matching
the
tissue
satisfactorily,
thus
diminishing
their
repairing
capability.
By
introducing
auxeticity
into
this
study
is
trying
to
present
beneficial
approach
address
these
shortcomings
patches.
The
featuring
auxetic
effect,
offer
unparalleled
conformity
complex
challenges.
Initially,
scaffolds
demonstrating
effect
were
designed
by
merging
chiral
rotation
and
concave
angle
units,
followed
integrating
composite
hydrogel
through
thermally
triggering,
ensuring
excellent
biocompatibility
closely
mirroring
heart
tissue.
Tensile
tests
revealed
possessed
elasticity
strain
capacity
exceeding
tissue's
physiological
activity.
Notably,
Model
III
showed
an
equivalent
modulus
ratio
toward
tissue,
underscoring
its
outstanding
potential
as
Cyclic
tensile
loading
demonstrated
withstood
continuous
heartbeats,
showcasing
cyclic
recovery
capabilities.
Numerical
simulations
further
elucidated
failure
mechanisms
leading
exploration
influence
on
alternative
design
parameters,
which
enabled
customization
strength
ratio.
Therefore,
research
presents
substantial
for
designing
can
emulate
possess
adjustable
parameters.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(32)
Published: May 27, 2024
Citrate-based
biodegradable
polymers
have
emerged
as
a
distinctive
biomaterial
platform
with
tremendous
potential
for
diverse
medical
applications.
By
harnessing
their
versatile
chemistry,
these
exhibit
wide
range
of
material
and
bioactive
properties,
enabling
them
to
regulate
cell
metabolism
stem
differentiation
through
energy
metabolism,
metabonegenesis,
angiogenesis,
immunomodulation.
Moreover,
the
recent
US
Food
Drug
Administration
(FDA)
clearance
poly(octamethylene
citrate)
(POC)/hydroxyapatite-based
orthopedic
fixation
devices
represents
translational
research
milestone
science.
POC
joins
short
list
synthetic
that
ever
been
authorized
by
FDA
use
in
humans.
The
clinical
success
has
sparked
enthusiasm
accelerated
development
next-generation
citrate-based
biomaterials.
This
review
presents
comprehensive,
forward-thinking
discussion
on
pivotal
role
citrate
chemistry
various
tissue
regeneration
functional
metabotissugenic
biomaterials
regenerative
engineering
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Journal Year:
2024,
Volume and Issue:
157, P. 106661 - 106661
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 26, 2024
Abstract
Electrospinning
is
a
significant
manufacturing
strategy
to
create
micro/nanofiber
platforms
that
can
be
considered
biomedical
scaffold
for
tissue
engineering
repair
and
regeneration.
In
recent
years
researchers
have
continuously
broadened
the
equipment
design
materials
development
of
electrospinning
nanofiber
(ENPs),
which
evolved
from
single‐needle
multi‐needle
creating
3D
ENPs,
diversify
their
application
including
drugs/cell/growth
factors
release,
anti‐bacterial
anti‐inflammatory,
hemostasis,
wound
healing,
Herein,
multifunctional
ENPs
with
bioactive
polymer
fabricated
via
in
terms
novel
material
design,
construction
various
structures,
requirements
different
regeneration
are
reviewed.
Furthermore,
this
review
delves
into
advancements
facilitated
by
highlighting
effectiveness
versatility
across
types
such
as
bone,
cartilage,
tendons,
cardiac
tissue,
nerves.
The
discussion
comprehensively
addresses
ongoing
challenges
selection,
biodegradation
mechanisms,
bioactivation
strategies,
techniques
specific
applications.
Moreover,
outlines
potential
future
research
avenues
aimed
at
enhancing
ENPs‐based
approaches
engineering.
This
in‐depth
analysis
aims
provide
nuanced
insights
technical
recommendations
propel
field
forward
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 16, 2024
Abstract
Diabetic
foot
ulcers
(DFU)
are
notoriously
challenging
to
heal
due
severe
infection,
excessive
inflammation,
and
difficulty
in
angiogenesis.
In
response
these
problems,
first,
a
pH/glucose
dual‐responsive
hydrogel
dressing
(HPC)
is
constructed
using
dual
dynamic
crosslinking
through
Schiff
base
phenylboronate
ester
between
m‐aminophenylboronic
acid
adipic
dihydrazide
bifunctionalized
hyaluronic
(AHP)
oxidized
chondroitin
sulfate
(OCS).
Then,
polydopamine‐reduced
graphene
oxide
compounded
glycine‐modified
fullerene
(GPC)
with
photothermal/photodynamic
synergistic
antibacterial
properties
the
drug
pirfenidone
(PFD)
pro‐angiogenesis
suppress
inflammatory
loaded
into
above
HPC
hydrogel.
Based
on
of
base/phenylboronate
pH/glucose,
HPC/GPC/PFD
(HPCG/PFD)
can
accelerate
release
PFD,
thereby
improving
inflammation
angiogenesis
DFU.
addition,
provided
good
on‐demand
removal
self‐healing
performance,
while
GPC
brought
tissue
adhesion,
antioxidation,
electrical
conductivity
The
rheology,
morphology,
mechanical
properties,
swelling,
degradation,
biocompatibility
have
been
well
verified.
Finally,
DFU
model
rats,
this
promote
wound
repair
by
reducing
infection
accelerating
closure,
enhancing
epidermal
regeneration,
collagen
deposition,
angiogenesis,
showing
promoting
effect
diabetic
healing.
Biomaterials Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
3D
bioprinted
PLA
scaffolds
with
curcumin-loaded
lipid
carriers
show
antimicrobial
activity
and
promote
skin
regeneration,
offering
promise
for
wound
healing.