Chitosan as a tool for tissue engineering and rehabilitation: Recent developments and future perspectives – A review

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134172 - 134172

Published: Aug. 5, 2024

Language: Английский

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Bio‐Based Elastomers: Design, Properties, and Biomedical Applications

Advanced Materials, Journal Year: 2025, Volume and Issue: 37(22)

Published: Jan. 13, 2025

Abstract To reduce carbon footprint and human dependence on fossil fuels, the field of bio‐based polymers has undergone explosive growth in recent years. Among them, elastomers have gained tremendous attention for their inherent softness, high strain, resilience. In this review, progress representative derived from molecular building blocks biopolymers are recapitulated, with an emphasis design, synthesis approaches, mechanical performance. The performance‐advantaged properties elastomers, including immune modulation, biocompatibility, biodegradability also explored. Furthermore, biomedical applications wound dressing, cardiovascular, nerve repair, bone biosensors exemplified. Lastly, challenges outlooks development discussed. This review aims to offer readers valuable insights into potential as viable alternatives petroleum‐based counterparts, supporting transition toward a more sustainable future.

Language: Английский

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NIR-programmable 3D-printed shape-memory scaffold with dual-thermal responsiveness for precision bone regeneration and bone tumor management

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 17, 2025

Clinically, intraoperative treatment of bone tumors presents several challenges, including the effective inactivation and filling irregular defects after tumor removal. In this study, intelligent thermosensitive composite materials with shape-memory properties were constructed using polylactic acid (PLA) polycaprolactone (PCL), which have excellent biocompatibility degradability. Additionally, beta-tricalcium phosphate (β-TCP), its osteogenic properties, magnesium (Mg) powder, photothermal bone-promoting abilities, incorporated to improve potential enable material respond intelligently near-infrared (NIR) light. Utilizing 3D printing technology, was prepared into an NIR-responsive bone-filling implant that deforms when scaffold temperature increases 48 ℃ under NIR laser irradiation. Moreover, at a lower 42 ℃, mild therapy promotes macrophage polarization toward M2 phenotype. This process regulates secretion interleukin (IL)-4, IL-10, necrosis factor-α, IL-6, morphogenetic protein (BMP)-2, reducing local inflammation, enhancing release pro-healing factors, improving osteogenesis. Overall, innovative is promising efficient for surgery.

Language: Английский

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Composite patch with negative Poisson's ratio mimicking cardiac mechanical properties: Design, experiment and simulation

Materials Today Bio, Journal Year: 2024, Volume and Issue: 26, P. 101098 - 101098

Published: May 22, 2024

Developing patches that effectively merge intrinsic deformation characteristics of cardiac with superior tunable mechanical properties remains a crucial biomedical pursuit. Currently used traditional block-shaped or mesh patches, typically incorporating positive Poisson's ratio, often fall short matching the tissue satisfactorily, thus diminishing their repairing capability. By introducing auxeticity into this study is trying to present beneficial approach address these shortcomings patches. The featuring auxetic effect, offer unparalleled conformity complex challenges. Initially, scaffolds demonstrating effect were designed by merging chiral rotation and concave angle units, followed integrating composite hydrogel through thermally triggering, ensuring excellent biocompatibility closely mirroring heart tissue. Tensile tests revealed possessed elasticity strain capacity exceeding tissue's physiological activity. Notably, Model III showed an equivalent modulus ratio toward tissue, underscoring its outstanding potential as Cyclic tensile loading demonstrated withstood continuous heartbeats, showcasing cyclic recovery capabilities. Numerical simulations further elucidated failure mechanisms leading exploration influence on alternative design parameters, which enabled customization strength ratio. Therefore, research presents substantial for designing can emulate possess adjustable parameters.

Language: Английский

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Citric Acid: A Nexus Between Cellular Mechanisms and Biomaterial Innovations

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(32)

Published: May 27, 2024

Citrate-based biodegradable polymers have emerged as a distinctive biomaterial platform with tremendous potential for diverse medical applications. By harnessing their versatile chemistry, these exhibit wide range of material and bioactive properties, enabling them to regulate cell metabolism stem differentiation through energy metabolism, metabonegenesis, angiogenesis, immunomodulation. Moreover, the recent US Food Drug Administration (FDA) clearance poly(octamethylene citrate) (POC)/hydroxyapatite-based orthopedic fixation devices represents translational research milestone science. POC joins short list synthetic that ever been authorized by FDA use in humans. The clinical success has sparked enthusiasm accelerated development next-generation citrate-based biomaterials. This review presents comprehensive, forward-thinking discussion on pivotal role citrate chemistry various tissue regeneration functional metabotissugenic biomaterials regenerative engineering

Language: Английский

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Procoagulant, antibacterial and antioxidant high-strength porous hydrogel adhesives in situ formed via self-gelling hemostatic microsheets for emergency hemostasis and wound repair

Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122936 - 122936

Published: Oct. 31, 2024

Language: Английский

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Dual-functional Hydroxyapatite scaffolds for bone regeneration and precision drug delivery

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2024, Volume and Issue: 157, P. 106661 - 106661

Published: July 14, 2024

Language: Английский

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Recent Progress in Biomedical Scaffold Fabricated via Electrospinning: Design, Fabrication and Tissue Engineering Application

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Electrospinning is a significant manufacturing strategy to create micro/nanofiber platforms that can be considered biomedical scaffold for tissue engineering repair and regeneration. In recent years researchers have continuously broadened the equipment design materials development of electrospinning nanofiber (ENPs), which evolved from single‐needle multi‐needle creating 3D ENPs, diversify their application including drugs/cell/growth factors release, anti‐bacterial anti‐inflammatory, hemostasis, wound healing, Herein, multifunctional ENPs with bioactive polymer fabricated via in terms novel material design, construction various structures, requirements different regeneration are reviewed. Furthermore, this review delves into advancements facilitated by highlighting effectiveness versatility across types such as bone, cartilage, tendons, cardiac tissue, nerves. The discussion comprehensively addresses ongoing challenges selection, biodegradation mechanisms, bioactivation strategies, techniques specific applications. Moreover, outlines potential future research avenues aimed at enhancing ENPs‐based approaches engineering. This in‐depth analysis aims provide nuanced insights technical recommendations propel field forward

Language: Английский

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Photothermal/Photodynamic Synergistic Antibacterial Hydrogel Dressing with pH/Glucose Dual Responsive Pirfenidone Release for Diabetic Foot Ulcers

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 16, 2024

Abstract Diabetic foot ulcers (DFU) are notoriously challenging to heal due severe infection, excessive inflammation, and difficulty in angiogenesis. In response these problems, first, a pH/glucose dual‐responsive hydrogel dressing (HPC) is constructed using dual dynamic crosslinking through Schiff base phenylboronate ester between m‐aminophenylboronic acid adipic dihydrazide bifunctionalized hyaluronic (AHP) oxidized chondroitin sulfate (OCS). Then, polydopamine‐reduced graphene oxide compounded glycine‐modified fullerene (GPC) with photothermal/photodynamic synergistic antibacterial properties the drug pirfenidone (PFD) pro‐angiogenesis suppress inflammatory loaded into above HPC hydrogel. Based on of base/phenylboronate pH/glucose, HPC/GPC/PFD (HPCG/PFD) can accelerate release PFD, thereby improving inflammation angiogenesis DFU. addition, provided good on‐demand removal self‐healing performance, while GPC brought tissue adhesion, antioxidation, electrical conductivity The rheology, morphology, mechanical properties, swelling, degradation, biocompatibility have been well verified. Finally, DFU model rats, this promote wound repair by reducing infection accelerating closure, enhancing epidermal regeneration, collagen deposition, angiogenesis, showing promoting effect diabetic healing.

Language: Английский

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3D bioprinted poly(lactic acid) scaffolds infused with curcumin-loaded nanostructured lipid carriers: a promising approach for skin regeneration

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

3D bioprinted PLA scaffolds with curcumin-loaded lipid carriers show antimicrobial activity and promote skin regeneration, offering promise for wound healing.

Language: Английский

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