Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
12
Published: Dec. 20, 2024
Abstract
During
the
implantation
process
of
cardiovascular
implants,
vascular
damage
caused
by
inflammation
occurs,
and
inflammatory
is
accompanied
oxidative
stress.
Currently,
carbon
monoxide
(CO)
has
been
demonstrated
to
exhibit
various
biological
effects
including
vasodilatation,
antithrombotic,
anti-inflammatory,
apoptosis-inducing
antiproliferative
properties.
In
this
study,
hemoglobin/epigallocatechin-3-gallate
(EGCG)
core-shell
nanoparticle-containing
coating
on
stainless
steel
was
prepared
for
CO
loading
modulation.
Inspired
strong
coordination
ability
with
CO,
hemoglobin
nanoparticle
first
encapsulated
into
EGCG
metal-phenolic
networks.
A
polydopamine
(PDA)
linking
layer
then
coated
316
steel,
hemoglobin/EGCG
nanoparticles
were
loaded
subsequent
PDA
deposition.
It
showed
that
maximum
release
amount
17.0
nmol/cm2
in
48
h.
vitro
evaluations
conducted
a
simulated
environment
revealed
coating,
which
released
from
nanoparticles,
effectively
mitigated
lipopolysaccharide-induced
response
macrophages.
Specifically,
it
decreased
expression
tumor
necrosis
factor-α,
increased
interleukin-10,
suppressed
polarization
macrophages
toward
M1
phenotype
reduced
intracellular
reactive
oxygen
species
(ROS).
Furthermore,
under
stress
conditions,
apoptosis
endothelial
cells
induced
down-regulated
ROS
levels.
vivo
results
further
confirmed
its
capabilities,
macrophage-mediated
responses
modulated
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 13, 2025
Abstract
A
magnetically
responsive
shape
memory
silicone
composite
is
developed
for
fabricating
an
active
valve
in
biomedical
fluidic
systems.
The
consists
of
magnetic
neodymium–iron–boron
(NdFeB)
microparticles
(MPs)
and
poly(glycerol‐dodecanoate)
(PGD)
MPs
silicone.
PGD
has
tunable
transition
temperatures
(
T
g
)
42—50
°C,
empowering
programmability
to
the
composite,
while
NdFeB
make
a
field
gradient.
can
be
reprogrammed
into
compact
form
ease
delivery
subsequently
recovered
its
original
stimulated
by
external
heat
that
generated
oscillation
B
h
applied
MPs.
Because
dramatically
reduced
stiffness
above
,
actuated
different
one
exerted
torques
induced
simultaneously
actuation
).
By
tuning
density
direction
changing
extent,
e.g.,
bending
angles,
which
determine
fluid
flow
resistance,
modulated.
This
works
provides
proof‐of‐concept
programmable,
remotely
controlled
regulation.
adaptability,
biocompatibility,
capability
minimally
invasive
highlight
potential
applications
drug
delivery,
embolization,
management
blood
vessels
eyes.
Journal of Materials Chemistry B,
Journal Year:
2024,
Volume and Issue:
12(11), P. 2877 - 2893
Published: Jan. 1, 2024
A
new
kind
of
superhydrophilic
drug-carrying
coating
was
synthesized
from
dopamine
and
rapamycin
to
prevent
nasolacrimal
duct
obstructing
through
anti-inflammation,
anti-infection
anti-fibrosis
regulation.
This
research
provides
a
versatile
surface
bioengineering
strategy.
The
advancement
of
antithrombotic
materials
has
significantly
mitigated
the
thrombosis
issue
in
clinical
applications
involving
various
medical
implants.
Extensive
research
been
dedicated
over
past
few
decades
to
developing
blood-contacting
with
complete
resistance
thrombosis.
However,
despite
these
advancements,
risk
and
other
complications
persists
when
are
implanted
human
body.
Consequently,
modification
enhancement
remain
pivotal
21st-century
hemocompatibility
studies.
Previous
indicates
that
healthy
endothelial
cells
(ECs)
layer
is
uniquely
compatible
blood.
Inspired
by
bionics,
scientists
have
initiated
development
emulate
hemocompatible
properties
ECs
replicating
their
diverse
mechanisms.
This
review
elucidates
mechanisms
examines
endothelium-mimicking
developed
through
single,
dual-functional
multifunctional
strategies,
focusing
on
nitric
oxide
release,
fibrinolytic
function,
glycosaminoglycan
modification,
surface
topography
modification.
These
demonstrated
outstanding
performance.
Finally,
outlines
potential
future
directions
this
dynamic
field,
aiming
advance
materials.
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(17), P. 4407 - 4426
Published: Jan. 1, 2024
Renal
ischemia/reperfusion
injury
(RIRI)
is
an
inevitable
complication
following
kidney
transplantation
surgery,
accompanied
by
the
generation
of
a
large
amount
free
radicals.
A
cascade
events
including
oxidative
stress,
extreme
inflammation,
cellular
apoptosis,
and
thrombosis
disrupts
microenvironment
renal
cells
hematological
system,
ultimately
leading
to
development
acute
(AKI).
The
current
research
primarily
focuses
on
reducing
inflammation
mitigating
damage
through
antioxidative
approaches.
However,
studies
simultaneously
modulating
hematologic
system
remain
unreported.
Herein,
potent
novel
drug-loaded
nanomicelles
can
be
efficiently
self-assembled
with
magnolol
(MG)
ebselen
(EBS)
π-π
conjugation,
hydrophobic
action
surfactant
properties
Tween-80.
ultrasmall
MG/EBS
(average
particle
size:
10-25
nm)
not
only
fully
preserve
activity
both
drugs,
but
also
greatly
enhance
drug
utilization
(encapsulation
rates:
MG:
90.1%;
EBS:
49.3%)
reduce
toxicity.
Furthermore,
EBS,
as
glutathione
peroxidase
mimic
NO
catalyst,
combines
multifunctional
MG
scavenge
radicals
hydroperoxides,
significantly
inhibiting
while
effectively
preventing
apoptosis
vascular
endothelial
tubular
epithelial
cells.
This
study
provides
new
strategy
theoretical
foundation
for
simultaneous
regulation
blood
stability.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 11, 2024
Biomolecule
isolation
is
a
crucial
process
in
diverse
biomedical
and
biochemical
applications,
including
diagnostics,
therapeutics,
research,
manufacturing.
Recently,
MXenes,
novel
class
of
two-dimensional
nanomaterials,
have
emerged
as
promising
adsorbents
for
this
purpose
due
to
their
unique
physicochemical
properties.
These
biocompatible
antibacterial
nanomaterials
feature
high
aspect
ratio,
excellent
conductivity,
versatile
surface
chemistry.
This
timely
review
explores
the
potential
MXenes
isolating
wide
range
biomolecules,
such
proteins,
nucleic
acids,
small
molecules,
while
highlighting
key
future
research
trends
innovative
applications
poised
transform
field.
provides
an
in-depth
discussion
various
synthesis
methods
functionalization
techniques
that
enhance
specificity
efficiency
biomolecule
isolation.
In
addition,
mechanisms
by
which
interact
with
biomolecules
are
elucidated,
offering
insights
into
selective
adsorption
customized
separation
capabilities.
also
addresses
recent
advancements,
identifies
existing
challenges,
examines
emerging
may
drive
next
wave
innovation
rapidly
evolving
area.
