International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138900 - 138900
Published: Dec. 1, 2024
Language: Английский
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(17), P. 8632 - 8712
Published: Jan. 1, 2024
Bioelectronics is a hot research topic, yet an important tool, as it facilitates the creation of advanced medical devices that interact with biological systems to effectively diagnose, monitor and treat broad spectrum health conditions. Electrical stimulation (ES) pivotal technique in bioelectronics, offering precise, non-pharmacological means modulate control processes across molecular, cellular, tissue, organ levels. This method holds potential restore or enhance physiological functions compromised by diseases injuries integrating sophisticated electrical signals, device interfaces, designs tailored specific mechanisms. review explains mechanisms which ES influences cellular behaviors, introduces essential principles, discusses performance requirements for optimal systems, highlights representative applications. From this review, we can realize based bioelectronics therapy, regenerative medicine rehabilitation engineering technologies, ranging from tissue neurological modulation cardiovascular cognitive functions. underscores versatility various biomedical contexts emphasizes need adapt complex clinical landscapes addresses.
Language: Английский
Citations
22
ACS Nano, Journal Year: 2024, Volume and Issue: 18(19), P. 12025 - 12048
Published: May 6, 2024
Cardiac interfacing devices are essential components for the management of cardiovascular diseases, particularly in terms electrophysiological monitoring and implementation therapies. However, conventional cardiac typically composed rigid bulky materials thus pose significant challenges effective long-term with curvilinear surface a dynamically beating heart. In this regard, recent development intrinsically soft bioelectronic using nanocomposites, which fabricated by blending conductive nanofillers polymeric elastomeric matrices, has shown great promise. The bioelectronics not only endure dynamic motion heart maintain stable performance but also enable conformal, reliable, large-area target tissue, allowing high-quality mapping, feedback electrical stimulations, even mechanical assistance. Here, we explore next-generation strategies based on that utilize elastic nanocomposites. We first discuss used to manage diseases explain their undesired limitations. Then, introduce restraint utilizing materials. After discussion fabrication functionalization nanomaterials, introduction nanocomposites application therapy follow. Finally, comments future prospects technologies discussed.
Language: Английский
Citations
17
Cyborg and Bionic Systems, Journal Year: 2024, Volume and Issue: 5
Published: Jan. 1, 2024
With the prevalence of cardiovascular disease, it is imperative that medical monitoring and treatment become more instantaneous comfortable for patients. Recently, wearable implantable optoelectronic devices can be seamlessly integrated into human body to enable physiological in an imperceptible spatiotemporally unconstrained manner, opening countless possibilities intelligent healthcare paradigm. To achieve biointegrated cardiac healthcare, researchers have focused on novel strategies construction flexible/stretchable systems. Here, we overview progress flexible stretchable optoelectronics devices. Firstly, device design addressed, including mechanical design, interface adhesion, encapsulation strategies. Next, practical applications monitoring, optogenetics, nongenetic stimulation are presented. Finally, outlook systems discussed.
Language: Английский
Citations
17
Journal of Electrical Engineering, Journal Year: 2025, Volume and Issue: 76(1), P. 72 - 79
Published: Feb. 1, 2025
Abstract This paper presents an approach based on eddy currents induced by suitable magnetic induction fields to test, estimate, and classify subsurface delaminations in Carbon Fibre Reinforced Polymer (CFRP) plates for biomedical devices. The two-dimensional maps obtained, characterised high fuzziness, required the software development of a procedure highly efficient fuzzy classifier that exploits similarity computations with reduced computational load collecting similar (deriving from equally defects) specific defects. hardware implementation what is designed (plate-probe system) detects evaluates entity defects due classification percentage comparable performances obtained more sophisticated classifiers, providing possible tool evaluating potentially useful assess aircraft compliance applicable safety standards.
Language: Английский
Citations
6
Biomaterials, Journal Year: 2024, Volume and Issue: 310, P. 122632 - 122632
Published: May 28, 2024
Language: Английский
Citations
16
Nano Trends, Journal Year: 2024, Volume and Issue: 7, P. 100042 - 100042
Published: June 18, 2024
Piezoelectricity has emerged as a pivotal platform technology in bioengineering to advance cardiac healthcare. Unlike common pacemakers, these devices capitalize on the mechanical energy derived from movements power themselves, presenting sustainable alternative battery constraints faced by current implantable devices. This review explores advances piezoelectric nanogenerators for monitoring and therapy, highlighting their capabilities not only track activity, but also provide therapeutic interventions reliable pacemakers. It discusses electric stimulation effects biocompatible integration with human biology, positioning at forefront of healthcare solutions, thereby enhancing effectiveness, durability, personalized care.
Language: Английский
Citations
5
Science Advances, Journal Year: 2024, Volume and Issue: 10(37)
Published: Sept. 11, 2024
The precise control of crack propagation at bonded interfaces is crucial for smart adhesives with advanced performance. However, previous studies have primarily concentrated on either microscale or macroscale propagation. Here, we present a hybrid adhesive that integrates microarchitectures and macroscopic nonlinear cut architectures unparalleled adhesion control. integration these architectural elements enables conformal attachment simultaneous trapping across multiple scales high capacity, enhancing by more than 70×, while facilitating the in specific directions programmable release reusability. As strength directionality can be independently controlled any location, skin patches are created breathable, nondamaging, exceptionally strong secure yet remove easily. These capabilities demonstrated skin-mounted patch integrated electronics accurately detects human motion wirelessly transmits signals, enabling real-time avatars virtual reality applications.
Language: Английский
Citations
5
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163222 - 163222
Published: May 1, 2025
Language: Английский
Citations
0
Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 217 - 241
Published: Feb. 19, 2025
Language: Английский
Citations
0
ACS Macro Letters, Journal Year: 2025, Volume and Issue: unknown, P. 448 - 457
Published: March 20, 2025
Ionic hydrogels are ideal for soft bioelectronics due to their softness, stretchability, and ion-mediated signal transduction. However, traditional face dehydration freezing issues. Inspired by natural skin, this study creates a supramolecular ionic organogel using silk fibroin, zwitterionic polymers, Ca2+, ethylene glycol (EG). The is conductive, highly stretchable, adhesive, environmentally stable, biocompatible. Theoretical calculations reveal that interactions among groups, EG, water stronger than water-water interactions, converting "free" into "locked" water. This mechanism allows the retain over 90% of its weight after 30 days at 25 °C 60% relative humidity, while also resisting disrupting ice formation. Its conductivity, adhesion, biocompatibility enable applications in on-skin strain sensors electrodes monitoring motion recording electrophysiological signals. work elucidates molecular networks, provides design framework tolerant organogel, advances ion-conductive bioelectronics.
Language: Английский
Citations
0