Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
Abstract
Single‐atom
nanotherapies
have
received
numerous
attention
in
malignant
oncotherapy.
However,
the
insufficient
enzyme
substrate
and
upregulation
of
heat
shock
proteins
during
therapeutic
interventions
are
seldom
concurrently
noticed.
Herein,
a
novel
gas
empowered
dual‐cascade
synergistic
treatment
strategy
is
demonstrated
with
domino
effect,
which
can
sequentially
reinforce
single‐atom
nanozyme
(SAzyme)‐based
enzymatic
therapeutics
mild
photothermal
therapy
(PTT)
(<
45
°C).
In
proof‐of‐concept
study,
Fe
single
atom
(Fe/SAzyme)
loaded
hydrogen
sulfide
(H
2
S)
donor
NaHS
developed
for
HSPs‐silencing
mediated
PTT.
The
generated
H
S
suppresses
catalase
activity
to
achieve
“intracellular
O
conservation”,
thereby
furnishing
Fe/SAzyme
produce
abundant
cytotoxic
hydroxyl
radicals
(·OH)
augmented
therapeutics.
Then,
excess
·OH
induced
mitochondrial
dysfunction
blocks
adenosine
triphosphate
(ATP)
energy
supply
realize
cellular
remodeling,
hinders
overexpression
HSPs
enhances
PTT
both
vitro
vivo.
Consequently,
gas‐triggered
achieves
S/·OH/mitochondrial
endowing
SAzymes
maximum
antitumor
efficacy
via
combined
This
dual‐cascaded
gas/enzymatic/mild
oncotherapy
not
only
exhibits
new
pathway
gas‐facilitated
PTT,
but
also
offers
valuable
paradigm
application
“1
+
1
>
3”
multimodal
tumor
therapy.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 19, 2025
Abstract
Oxygen
(O
2
)
tension
within
a
tumor
is
considered
hallmark
of
sonodynamic
therapy
(SDT).
Herein,
multifunctional
nanoregulators,
CMCS‐Au‐SrS
(CAS),
are
reported,
which
assembled
by
carboxymethyl
chitosan(CMCS)
tethered
gold
nanoclusters
(Au
NCs)
as
sonosensitizers
and
sulfurate
donors
strontium
sulfide
nanoparticles
(SrS
NPs),
to
evoke
selective
SDT
in
hypoxic
tumors.
CAS
possess
tumor‐acidity
responsiveness
form
large‐size
aggregated
Au
NCs
with
shortened
bandgap
so
that
effectively
induce
powerful
reactive
oxygen
species
generation.
On
the
other
hand,
acidity
triggers
degradation
SrS
NPs
release
hydrogen
(H
S),
evoking
oxygenation
overcome
hypoxia.
This
junction
accelerated
sonosensiting
ability
boosts
amplified
efficacy.
More
importantly,
specific
glycolysis
induced
acidification
leads
selectively
accumulated
cancer
cells,
further
guaranteeing
execution
advanced
therapeutic
manners.
Additionally,
doping
Nd
3+
endows
second
near‐infrared
fluorescence
facilitate
vivo
tracing
property
good
tissue
penetration
(up
6
mm).
strategy
may
play
pioneering
role
develop
theranostic
reagents
improved
enrichment
capacity
enhanced
hypoxia
ACS Materials Letters,
Journal Year:
2024,
Volume and Issue:
6(6), P. 2369 - 2380
Published: May 16, 2024
To
overcome
the
oxidative
stress
and
resistance
of
cancer
stem
cells
(CSCs)
for
successful
metastatic
triple-negative
breast
(TNBC)
treatment,
we
report
polyhedral
oligosilsesquioxanes
(POSS)-based
metal-phenolic
networks
(MPNs)
that
integrate
hard
POSS
as
a
rigid
dendritic
macromolecular
moiety
binding
with
photosensitizer
(PS),
Chlorin
e6
(Ce6)
to
improve
reactive
oxygen
species
(ROS)
generation
efficiency
photodynamic
therapy
(PDT),
soft
metal
ions
dynamic
coordination-driven
co-self-assembly
an
antiapoptotic
protein
inhibitor,
sabutoclax
(Sab)
afford
MPN
nanoparticles
(NPs).
The
NPs
show
most
significant
inhibitory
effect
in
4T1
TNBC
proximal/distal
tumor
model
growth
inhibition
(TGI)
value
96.8%
distal
via
simultaneous
immunogenic
cell
death
(ICD)
induction,
tumor-associated
macrophages
(TAMs)
polarization,
CSCs
elimination.
This
study
presents
facile
approach
toward
first
POSS-based
network
coupled
hardness
softness
highly
efficient
immunotherapy
TNBC.
Small Structures,
Journal Year:
2024,
Volume and Issue:
5(7)
Published: April 26, 2024
Nanozymes,
nanomaterials
exhibiting
enzyme‐mimicking
activities,
have
gained
considerable
interest
in
biomedicine
due
to
their
stability,
adjustability,
and
cost‐efficiency.
Among
these,
metal–organic
framework
(MOF)‐based
nanozymes
distinguish
themselves
by
distinct
structure
customizable
characteristics.
Researchers
explored
MOF‐based
as
a
platform
for
developing
stimuli‐responsive
behaviors.
This
work
first
presents
the
categorization
of
nanozymes,
which
are
designed
mimic
catalytic
functions
oxidases,
peroxidases,
catalase,
superoxide
dismutase,
hydrolases,
multifunctional
enzymes.
Crafting
includes
customizing
reactions
particular
stimuli,
including
pH,
temperature,
light,
or
biomolecular
triggers,
ensuring
enhanced
specificity
potency
performance
amid
environmental
changes.
Moreover,
these
exhibit
immense
potential
biomedical
applications,
playing
crucial
roles
therapeutic
interventions
like
cancer
therapy
tissue
regeneration.
Finally,
article
delves
into
future
opportunities
challenges
within
emerging
research
frontiers.
These
offer
novel
avenues
advanced
strategies,
providing
prospects
innovative
applications.
Sublethal
tumor
cells
have
an
urgent
need
for
energy,
making
it
common
them
to
switch
metabolic
phenotypes
between
glycolysis
and
oxidative
phosphorylation
(OXPHOS)
compensatory
energy
supply;
thus,
the
synchronous
interference
of
dual
pathways
limiting
level
is
essential
in
inhibiting
sublethal
growth.
Herein,
a
multifunctional
nanoplatform
Co-MOF-loaded
anethole
trithione
(ADT)
myristyl
alcohol
(MA),
modified
with
GOx
hyaluronic
acid
(HA)
was
developed,
namely,
CAMGH.
It
could
synchronously
interfere
including
OXPHOS
restrict
adenosine
triphosphate
(ATP)
supply,
achieving
inhibition
tumors
after
microwave
(MW)
thermal
therapy.
Under
low-power
MW
irradiation,
CAMGH
induced
certain
damage
while
ensuring
safety
surrounding
normal
tissues.
The
loaded
consumed
glucose
tumors,
undoubtedly
blocking
main
supply
pathway,
glycolytic
pathway.
Then,
H
ACS Applied Nano Materials,
Journal Year:
2024,
Volume and Issue:
7(22), P. 25580 - 25592
Published: Nov. 2, 2024
Multidrug
resistance
(MDR)
has
long
been
a
fundamental
obstacle
in
tumor
chemotherapy.
MDR
is
often
associated
with
overexpression
of
an
adenosine
triphosphate
(ATP)-binding
cassette
transporter
resistant
cancer
cells,
which
highly
ATP-dependent.
Therefore,
reversing
by
down-regulated
ATP
expression
promising
strategy.
This
study
developed
redox-regulating
nanotherapeutic
for
boosting
ferroptosis,
MDR,
and
inducing
synergistic
therapy.
Fe(III)-chelated
polydopamine
(Fe-PDA)
the
key
to
design
such
nanotherapeutic,
laser
irradiation
can
speed
up
electron
transfer
between
Fe3+
Fe2+
production
hydroxyl
radical
(•OH).
Coating
layer
Fe-PDA
on
surface
mesoporous
silica
(MSN)-encapsulated
diallyl
trisulfide
(DATS),
doxorubicin
(DOX)
was
loaded
Fe-PDA.
Upon
triggering,
(DATS@MSN@Fe-PDA/DOX,
DMFPD)
produced
photothermal
(•OH)
hydrogen
sulfide
(H2S)
apoptotic
cell
death.
The
DATS
depleted
intracellular
glutathione
(GSH),
together
H2S
boosted
ferroptosis.
Ferroptosis
effectively
caused
mitochondrial
dysfunction,
thereby
suppressing
expression.
interactive
death
chemotherapy
sensitization
were
further
demonstrated
4T1
tumor-bearing
mouse
model
high
level
biosafety.
provides
strategy
clinical
theragnostics.
