Ruthenium-doped carbon dots with “three-in-one” chemodynamic, photodynamic, and photothermal activity induce panoptosis for tumor therapy

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161355 - 161355

Published: March 1, 2025

Language: Английский

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Calcium peroxide functionalized mesoporous polydopamine nanoparticles triggered calcium overload for synergistic tumor gas/photothermal therapy

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 690, P. 137332 - 137332

Published: March 14, 2025

Language: Английский

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MnO2 and sonosensitizer-based nano-platforms for cancer sonodynamic therapy

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157232 - 157232

Published: Oct. 30, 2024

Language: Английский

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Immunomodulating Sonocatalytic Nanoagents with Dual‐Functional Ir‐N Centers and Narrow Bandgap for Reversing Immunosuppression and Potentiating Ovarian Cancer Immunotherapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(46)

Published: July 1, 2024

Abstract The heterogeneity and immunosuppression microenvironment of ovarian cancer seriously restrict the efficiency monomodal treatment. Emerging multimodal therapy strategies based on sonodynamic with enhanced antitumor effects have attracted intensive attention in quest to combat cancer. However, exploring highly efficient sonosensitizers integrating chemodynamic/sonodynamic/immunotherapies reversing immunosuppressive tumor (TME) capacity is urgently desired but remains challenging. Here, a facile strategy designed synthesize immunomodulating sonocatalytic nanoagents (IrT‐SCN) dual‐functional Ir‐N centers narrow bandgap for potentiating immunotherapy. IrT‐SCN 2 4 conjugated networks show reduced bandgap, moderate interaction H O , production reactive oxygen species (ROS). Such ROS capabilities include: 1) utilizing TME catalytically generate potent as well abundant superoxide anion (•O − ) singlet ( 1 radicals; 2) external ultrasound (US) irradiation can also boost simultaneously; 3) M1 polarization tumor‐associated macrophages immune effect promote outcome This finding provides proof‐of‐concept evidence future development oncological treatments other ROS‐related biomedical fields.

Language: Английский

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Endoplasmic reticulum-targeted iridium(III) photosensitizer induces pyroptosis for augmented tumor immunotherapy

Journal of Inorganic Biochemistry, Journal Year: 2024, Volume and Issue: 260, P. 112695 - 112695

Published: Aug. 11, 2024

Language: Английский

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Targeting of Low‐Immunogenic Poly(ethylene glycol) Nanoparticles for Photothermal‐Enhanced Immunotherapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Abstract The assembly of low‐immunogenic poly(ethylene glycol) nanoparticles (PEG NPs) for targeted delivery therapeutics (i.e., mitoxantrone and imidazoquinoline) improved photothermal‐immunotherapy is reported. PEG NPs incorporating targeting molecules hyaluronic acid are engineered via the templating metal–organic frameworks, which can circumvent accelerated blood clearance exhibit prolonged circulation time as well accumulation at tumor sites. under laser radiation induces immunogenic cell death cells, combined with toll‐like receptor 7/8 agonists imidazoquinoline to trigger immune responses cytotoxic T lymphocytes eradication cells. Furthermore, treatment induce tumor‐specific that inhibit metastatic lung growth. This reported provide a rational design cancer immunotherapy.

Language: Английский

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Tumor‐Targeted Catalytic Immunotherapy

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 15, 2024

Cancer immunotherapy holds significant promise for improving cancer treatment efficacy; however, the low response rate remains a considerable challenge. To overcome this limitation, advanced catalytic materials offer potential in augmenting by modulating immunosuppressive tumor microenvironment (TME) through precise biochemical reactions. Achieving optimal targeting precision and therapeutic efficacy necessitates thorough understanding of properties underlying mechanisms tumor-targeted materials. This review provides comprehensive systematic overview recent advancements their critical role enhancing immunotherapy. It highlights types reactions, construction strategies materials, fundamental targeting, including passive, bioactive, stimuli-responsive, biomimetic approaches. Furthermore, outlines various tumor-specific strategies, encompassing tissue, cell, exogenous TME-responsive, cellular TME strategies. Finally, discussion addresses challenges future perspectives transitioning into clinical applications, offering insights that pave way next-generation therapies provide substantial benefits to patients settings.

Language: Английский

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Progress in application of nanomedicines for enhancing cancer sono-immunotherapy

Ultrasonics Sonochemistry, Journal Year: 2024, Volume and Issue: 111, P. 107105 - 107105

Published: Oct. 15, 2024

Language: Английский

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Multienzyme-like polyoxometalate for oxygen-independent sonocatalytic enhanced cancer therapy

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 681, P. 319 - 330

Published: Nov. 23, 2024

Language: Английский

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