Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Abstract
Photothermal
hydrogels
(PTHs)
are
considered
next‐generation
biomaterials
as
they
offer
remotely
defined
biophysical
information
of
the
extracellular
milieu.
PTHs
allow
precise
and
non‐genetic
control
for
regeneration
native
tissues,
which
is
ultimate
goal
tissue
engineering
(TE).
Molecular
physical
properties
PTHs,
such
components,
structural
configurations,
mechanical
characteristics,
collectively
serve
determinants
understanding
dynamic
response
clinical
translation.
have
entered
a
period
fruition
due
to
development
numerous
manufacturing
technologies
polymeric
matrices.
Herein,
this
review
comprehensively
meticulously
elucidates
mechanisms
regenerative
therapeutics
underlying
design
fabrication
PTHs.
Recent
advances
in
photothermal
principles
various
categories
agents
(PTAs)
been
extensively
discussed.
Vital
components
structures
summarized
enable
efficacious
therapeutic
energy
delivery.
Emerging
applications
TE
also
demonstrated,
expand
strategies
intrinsic
injured
tissues.
Then
deliberate
chemical
enhance
prognosis
while
highlighting
challenges
associated
with
In
review,
we
aim
provide
guidance
prospects
exploration
innovation
field
TE.
Biomaterials Research,
Journal Year:
2024,
Volume and Issue:
28
Published: Jan. 1, 2024
Skull
defect
repair
is
a
complex
and
critical
medical
challenge,
there
an
urgent
need
to
develop
multifunctional
tissue
engineering
scaffolds
for
skull
regeneration.
The
success
of
bone
depends
on
the
construction
that
can
regulate
immune
microenvironment
regeneration
mimic
liquid
crystal
viscoelastic
properties
natural
extracellular
matrix.
Hence,
smart
hydrogel
(PEGDA5/AM15/CLC-BMP-4@MBG)
with
good
biocompatibility
ability
modulate
wound
has
been
developed
defects.
consists
chitin
(PEGDA5/AM15/CLC)
mesoporous
bioactive
glasses
(MBGs)
loaded
morphogenetic
protein-4
(BMP-4).
not
only
offers
necessary
biological
support
mechanical
but
also
maintains
stability
state,
facilitating
adhesion
surrounding
tissue.
In
addition,
BMP-4@MBG
intelligently
regulates
release
rate
BMP-4
in
response
changes
microenvironment,
thus
effectively
promoting
transformation
macrophages
from
M1
M2
macrophages.
At
same
time,
Ca
2+
Si
4+
released
by
MBG
degradation
synergically
promote
process.
PEGDA5/AM15/CLC-BMP-4@MBG
shows
excellent
immunomodulatory
osteogenic
promising
scaffold
material
engineering.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 10, 2024
Abstract
Photothermal
hydrogels
(PTHs)
are
considered
next‐generation
biomaterials
as
they
offer
remotely
defined
biophysical
information
of
the
extracellular
milieu.
PTHs
allow
precise
and
non‐genetic
control
for
regeneration
native
tissues,
which
is
ultimate
goal
tissue
engineering
(TE).
Molecular
physical
properties
PTHs,
such
components,
structural
configurations,
mechanical
characteristics,
collectively
serve
determinants
understanding
dynamic
response
clinical
translation.
have
entered
a
period
fruition
due
to
development
numerous
manufacturing
technologies
polymeric
matrices.
Herein,
this
review
comprehensively
meticulously
elucidates
mechanisms
regenerative
therapeutics
underlying
design
fabrication
PTHs.
Recent
advances
in
photothermal
principles
various
categories
agents
(PTAs)
been
extensively
discussed.
Vital
components
structures
summarized
enable
efficacious
therapeutic
energy
delivery.
Emerging
applications
TE
also
demonstrated,
expand
strategies
intrinsic
injured
tissues.
Then
deliberate
chemical
enhance
prognosis
while
highlighting
challenges
associated
with
In
review,
we
aim
provide
guidance
prospects
exploration
innovation
field
TE.
