The
effective
and
translational
strategy
to
regenerate
knee
meniscal
fibrocartilage
remained
challenging.
Herein,
we
first
identified
vascular
smooth
muscle
cells
(VSMCs)
transdifferentiated
into
fibrochondrocytes
participated
in
spontaneous
regeneration
using
cell
lineage
tracing
transgenic
mice
defect
model.
Then,
low-intensity
pulsed
ultrasound
(LIPUS)
acoustic
stimulus
enhanced
fibrochondrogenic
transdifferentiation
of
VSMCs
vitro
vivo.
Mechanistically,
LIPUS
could
up-regulate
mechanosensitive
ion
channel
Piezo1
expression
then
activate
the
transforming
growth
factor
β1
(TGFβ1)
signal,
following
repression
Notch
consequently
enhancing
VSMCs.
Finally,
demonstrated
that
regular
anisotropic
native-like
tissue
a
beagle
canine
subtotal
meniscectomy
model
at
6
months
postoperatively.
single-cell
RNA
sequencing
analysis
confirmed
role
VSMC
regeneration.
The
aging
population
necessitates
a
critical
need
for
medical
devices,
where
polymers-based
surface
lubrication
coating
is
essential
optimal
functionality.
In
fact,
and
mechanical
requirements
vary
depending
on
the
service
environment
of
different
devices.
Until
now,
key
mean
still
blank
general
preparation
hydrophilic
coatings
with
on-demand
mechanics
lubricity.
This
study
introduces
novel
tunable
properties
lubricity,
derived
from
eco-friendly
polymerizable
deep
eutectic
solvents
(PDESs)
containing
betaine,
hydroxyethyl
acrylate,
glycerol,
tannic
acid.
Unlike
traditional
high
molecular
weight
polymers,
this
approach
leverages
small-molecule,
high-biobased
PDESs,
thereby
simplifying
synthesis
process.
resulting
demonstrates
exceptional
adhesion
to
range
device
materials─including
glass,
stainless
steel,
polyvinyl
chloride,
polyurethane─thanks
content
hydroxyl
groups
pyrogallol
motifs
It
also
enables
precise
tuning
strength,
modulus,
adhesion,
hydrophilicity,
by
varying
amounts
glycerol
Furthermore,
undergoes
hydration-induced
transition
high-strength,
high-friction
low-strength,
low-friction
states,
maintaining
repeatable
performance.
Additionally,
synergistic
effects
betaine
acid
in
PDES
contribute
its
notable
antimicrobial
properties.
summary,
these
PDESs
demonstrate
significant
potential
enhancing
biomedical
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 14, 2025
Abstract
The
absence
of
a
meniscal
prosthesis
that
fully
accommodates
the
complex
motion
demands
human
knee
joint
remains
challenge
in
clinical
practice.
This
study
synthesized
polyurethane
elastomer
with
enhanced
mechanical
properties,
featuring
dynamic
dimethyldioxime‐urethane
structure
provides
self‐healing
capabilities.
Additionally,
adamantane‐grafted
hyaluronic
acid
has
been
integrated
into
containing
cyclodextrin,
imparting
self‐lubricating
properties
through
supramolecular
host‐guest
interactions
between
adamantane
and
cyclodextrin.
innovative
is
utilized
to
fabricate
(DPU@HA).
In
vitro
experiments
demonstrated
DPU@HA's
exceptional
cytocompatibility
chondrocytes.
vivo
studies
revealed
DPU@HA
significantly
protected
articular
cartilage
following
meniscus
removal
by
reducing
high
stress
within
cartilage,
thereby
inhibiting
Piezo1
overactivation
subsequent
chondrocyte
apoptosis.
With
its
(DPU@HA)
holds
promise
for
applications
preventing
progression
osteoarthritis
after
meniscectomy.
Macromolecular Rapid Communications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 15, 2024
Abstract
Natural
silk
nanofibers
(SNF)
are
attractive
conductive
substrates
due
to
their
high
aspect
ratio,
outstanding
mechanical
strength,
excellent
biocompatibility,
and
controllable
degradability.
However,
the
inherently
non‐conductivity
severely
restricts
potential
sensor
application
of
SNF‐based
aerogels.
In
this
work,
nanofibrous
aerogels
with
low‐density
achieved
through
freeze–drying
by
dispersing
carbon
nanotubes
(CNT)
into
SNF
suspension.
The
addition
CNT
significantly
increases
conductivity
improved
properties
composite
SEM
results
reveal
that
distinct
hierarchical
structure
comprising
micropores
networks
within
pores
is
formed
when
content
reached
30%.
Furthermore,
increased
cell
viability
suggested
biocompatibility
SNF‐CNT‐based
aerogel
for
tissue‐engineering
applications.
Subsequently,
elastic
water‐borne
polyurethane
(WPU)
incorporated
SNF‐CNT
system
construct
good
sensing
properties.
introduction
WPU
demonstrates
enhanced
compressive
performances
an
exceptionally
recovery
ratio
99.8%,
thereby
exhibiting
a
stable
lossless
strain‐sensing
signal
output
at
5%
strain.
This
study
provides
feasible
choice
strategy
exploring
in
functional
