Preparation and Utilization of a Highly Discriminative Absorbent Imprinted with Fetal Hemoglobin DOI Open Access
Ka Zhang, Tongchang Zhou, Cedric Dicko

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(19), P. 2734 - 2734

Published: Sept. 27, 2024

Development in hemoglobin-based oxygen carriers (HBOCs) that may be used as alternatives to donated blood requires an extensive supply of highly pure hemoglobin (Hb) preparations. Therefore, it is essential fabricate inexpensive, stable and selective absorbents for Hb purification. Molecular imprinting attractive technology preparing such materials targeted molecular recognition rapid separations. In this case study, we developed human fetal (HbF)-imprinted polymer beads through the fusion surface Pickering emulsion polymerization. HbF was firstly covalently coupled silica nanoparticles its surface-exposed amino groups. The particle-supported molecules were subsequently employed templates synthesis molecularly imprinted polymers (MIPs) with high selectivity Hb. After removing support HbF, resulting MIPs underwent equilibrium kinetic binding experiments both adult (HbA) HbF. These surface-imprinted exhibited excellent HbA facilitating one-step isolation recombinant from crude biological samples. saturation capacities found 15.4 17.1 mg/g polymer, respectively. present study opens new possibilities designed resins tailored protein purification, separation analysis.

Language: Английский

An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs DOI
Seol‐Ha Jeong,

Jarno Hiemstra,

Patrick V. Blokzijl

et al.

Bio-Design and Manufacturing, Journal Year: 2024, Volume and Issue: 7(3), P. 240 - 261

Published: May 1, 2024

Language: Английский

Citations

4
Kernel Representation-based End-to-End Network-enabled Decoding Strategy for Precise and Medical Diagnosis DOI

Qinyu Wang,

Xuewen Peng,

Niu Feng

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137233 - 137233

Published: Jan. 15, 2025

Language: Английский

Citations

0
Hemoglobin based oxygen carrier and its application in biomedicine DOI

Luoming Liu,

Kun Hou, Siyu Lin

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 532, P. 216508 - 216508

Published: Feb. 17, 2025

Language: Английский

Citations

0
Preparation and Utilization of a Highly Discriminative Absorbent Imprinted with Fetal Hemoglobin DOI Open Access
Ka Zhang, Tongchang Zhou, Cedric Dicko

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(19), P. 2734 - 2734

Published: Sept. 27, 2024

Development in hemoglobin-based oxygen carriers (HBOCs) that may be used as alternatives to donated blood requires an extensive supply of highly pure hemoglobin (Hb) preparations. Therefore, it is essential fabricate inexpensive, stable and selective absorbents for Hb purification. Molecular imprinting attractive technology preparing such materials targeted molecular recognition rapid separations. In this case study, we developed human fetal (HbF)-imprinted polymer beads through the fusion surface Pickering emulsion polymerization. HbF was firstly covalently coupled silica nanoparticles its surface-exposed amino groups. The particle-supported molecules were subsequently employed templates synthesis molecularly imprinted polymers (MIPs) with high selectivity Hb. After removing support HbF, resulting MIPs underwent equilibrium kinetic binding experiments both adult (HbA) HbF. These surface-imprinted exhibited excellent HbA facilitating one-step isolation recombinant from crude biological samples. saturation capacities found 15.4 17.1 mg/g polymer, respectively. present study opens new possibilities designed resins tailored protein purification, separation analysis.

Language: Английский

Citations

0