Fluorescent Fingerprint Identification of Protein Structural Changes and Disease-Specific Amyloid Beta Aggregates Based on a Single-Nanozyme Sensor Array

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

The misfolding of amyloid β (Aβ) peptides into an aggregation state is a central hallmark the onset Alzheimer's disease (AD). However, conventional methods are mainly focused on detecting specific Aβ peptide, which makes it difficult to recognize multiple analytes with different topological features and unfolded states at same time. Here, we propose simple universal sensing strategy construct fluorescence sensor array by using single-nanozyme probe combined three fluorescent substrates as recognition units protein structural changes identify between assemblies. In this system, fingerprint-like patterns produced from nonspecific interactions proteins units. As result, can accurately 13 kinds their mixtures ratios. Moreover, discriminate against diverse conformational forms. Most importantly, successfully distinguishes species, even in artificial cerebrospinal fluid samples human serum samples. This work provides attractive reliable for predicting pathologically relevant clinical diagnosis AD.

Language: Английский

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Nanoconfined Synthesis of CsPbBr₃ Quantum Dots: Enhanced Stability, Tunable Luminescence, and Sensitive Sensing Application

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

The integration of metal halide perovskite quantum dots (PQDs) into sensing technologies has been hindered by challenges in balancing environmental stability and sensitivity. In this work, mesoporous silica nanoparticles (MSNs) with tunable pore sizes were employed as nanoconfinement reactors to synthesize size-controlled CsPbBr3 PQDs (3.0-12.0 nm). nanoconfined environment facilitated the selective growth pure phases, avoiding unwanted Cs4PbBr6 formation. resulting PQDs, CsPbBr3@MSN, exhibited emission from blue green (470 515 nm), a high yield (36.8%), enhanced stability. Moreover, PQD composites demonstrated exceptional performance detecting pesticide dicloran, achieving detection limit 0.16 μM, far below China's national standard requirement (34.0 μM). mechanism involved competitive adsorption phase transitions cubic quasi-2D CsPb2Br5 phase. porous MSN structure maintained efficient mass energy transfer, ensuring both Beyond sensing, these nanocomposites show potential for applications anticounterfeiting fingerprint recognition. This study highlights powerful strategy developing robust, high-performance PQD-based fluorescent sensors.

Language: Английский

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Catalytic activity and selectivity of Cerium-Doped catalysts in dichloromethane oxidation

Inorganic Chemistry Communications, Journal Year: 2025, Volume and Issue: unknown, P. 114516 - 114516

Published: April 1, 2025

Language: Английский

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Reconstructed fluorine doped perovskites for electrocatalytic urea production through reaction pathways with CO2 and nitrate ions

Applied Catalysis B Environment and Energy, Journal Year: 2024, Volume and Issue: unknown, P. 124974 - 124974

Published: Dec. 1, 2024

Language: Английский

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