Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Microneedle
patches
have
emerged
as
a
promising
approach
for
diabetic
wound
healing
by
enabling
the
targeted
delivery
of
therapeutic
agents
such
stem
cells
and
their
derived
exosomes,
well
localized
bioactive
moieties.
These
offer
non-invasive
efficient
method
administering
payloads
directly
to
site
wound,
bypassing
systemic
circulation
minimizing
potential
side
effects.
The
holds
immense
promoting
tissue
regeneration
accelerating
in
patients.
Similarly,
cell-derived
which
are
known
regenerative
anti-inflammatory
properties,
can
enhance
process.
Furthermore,
microneedle
enable
precise
controlled
release
moieties,
growth
factors
cytokines,
site,
creating
conducive
microenvironment
repair
regeneration.
challenges
associated
with
multifaceted.
Biocompatibility
issues,
variability
skin
characteristics
among
patients,
regulatory
hurdles,
scalability,
cost
considerations,
long-term
stability,
patient
acceptance
compliance
all
present
significant
barriers
widespread
adoption
optimization
technology
clinical
practice.
Overcoming
these
will
require
collaborative
efforts
from
various
stakeholders
advance
field
address
critical
gaps
research
development.
Ongoing
focuses
on
enhancing
biocompatibility
mechanical
properties
materials,
developing
customizable
technologies
personalized
treatment
approaches,
integrating
advanced
functionalities
sensors
real-time
monitoring,
improving
engagement
adherence
through
education
support
mechanisms.
advancements
improve
management
providing
tailored
therapies
that
promote
faster
reduce
complications.
This
review
explores
current
landscape
context
management,
highlighting
both
need
be
addressed
future
perspectives
this
innovative
modality.
Small,
Journal Year:
2024,
Volume and Issue:
20(47)
Published: Aug. 15, 2024
Abstract
Nanotizing
biosealant
components
offer
a
multitude
of
chemical
functionalities
for
superior
adhesion–cohesion,
delivering
unique
properties
comprehensive
wound
healing
that
are
otherwise
impossible
to
achieve
using
commercial
variants.
For
the
first
time,
two‐step
controlled
hydrothermal
pyrolysis
is
reported
nanotize
dopamine,
phloroglucinol,
and
glutaraldehyde
into
carbon
dot
(CD)
be
subsequently
converted
carbonized
polymer
(CPD)
with
gelatin
as
co‐substrate.
Chemical
crosslinking
CD
through
Schiff
base
formation
before
second
step
ensures
complex
yet
porous
polymeric
network.
The
retention
indigenous
substrates
along
preservation
photoluminescence
in
CPD
optical
tracking
achieved.
A
nanoformulation
created
tannic
acid
(TA)
grafting
evolving
CPD‐TA
nanoglue
demonstrating
≈1.32
MPa
strength
lap
shear
tests
conducted
on
porcine
skin,
surpassing
traditional
bioadhesives.
uploaded
insulin
chosen
cargo
disbursal
at
site
normal
vitro
diabetic
models
HEKa
cells
extraordinary
biocompatibility.
Most
importantly,
can
generate
reactive
oxygen
species
(ROS)
scavenge
simultaneously
under
ambient
conditions
(23
W
white
LED
or
dark)
on‐demand
sterilization
aiding
recovery
ROS
scavenging.
Materials Futures,
Journal Year:
2024,
Volume and Issue:
3(3), P. 035401 - 035401
Published: May 24, 2024
Abstract
Islet
transplantation
is
a
promising
strategy
for
diabetes
mellitus
treatment
as
it
can
recapitulate
endogenous
insulin
secretion
and
provide
long-term
glycemic
control.
models
constructed
in
biomaterial
scaffolds
that
reproduce
biological
characteristics
of
native
islets
feasible
option
to
circumvent
the
dilemma
donor
shortage
requirement
chronic
immunosuppression.
Herein,
we
developed
bioinspired
artificial
microcapsule-based
islet
with
microvessels
control
using
microfluidic
electrospray
strategy.
Microfluidic
generate
uniform
hydrogel
microcapsules
core-shell
structure
encapsulating
cells.
The
cell-laden
enabled
efficient
transportation
nutrient,
oxygen,
insulin;
well
incorporation
prompting
glucose
responsiveness
molecular
exchange.
We
demonstrated
by
vivo
experiments
blood
glucose,
food
intake,
body
weight
diabetic
mouse
were
alleviated,
tolerance
was
promoted
after
engraftment
microcapsules.
further
improved
functionality
transplanted
model
secretion,
immune
escape,
microcirculation
standard
histological
analysis.
These
results
indicated
are
valuable
treating
diabetes.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 11, 2024
Surgical
excision
remains
the
principal
treatment
for
melanoma,
while
tumor
recurrence
and
delayed
wound
healing
often
occur
due
to
residual
cells
hypoxic
microenvironment
in
postoperative
skin
wounds.
Herein,
we
present
a
living
photosynthetic
microneedle
(MN)
patch
(namely
MA/CM@MN)
loaded
with
microalgae
(MA)
cuttlefish
melanin
(CM)
postsurgical
melanoma
therapy
healing.
Benefiting
from
oxygenic
photosynthesis
of
alive
MA
MN
base,
MA/CM@MN
can
generate
oxygen
under
light
exposure,
thus
facilitating
cell
proliferation
protecting
against
hypoxia-induced
death.
In
addition,
CM
nanoparticles
embedded
tips,
be
effectively
heated
up
near-infrared
(NIR)
irradiation,
contributing
strong
killing
efficacy
on
vitro.
Further
experiments
demonstrate
that
NIR-irradiated
prevents
local
simultaneously
promotes
tumor-induced
wounds
after
incomplete
resection
melanoma-bearing
mice,
probably
because
inhibit
proliferation,
stimulate
apoptosis,
mitigate
tissue
hypoxia
light.
These
results
indicate
offers
an
effective
therapeutic
strategy
cancer
applications.
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Microneedle
patches
have
emerged
as
a
promising
approach
for
diabetic
wound
healing
by
enabling
the
targeted
delivery
of
therapeutic
agents
such
stem
cells
and
their
derived
exosomes,
well
localized
bioactive
moieties.
These
offer
non-invasive
efficient
method
administering
payloads
directly
to
site
wound,
bypassing
systemic
circulation
minimizing
potential
side
effects.
The
holds
immense
promoting
tissue
regeneration
accelerating
in
patients.
Similarly,
cell-derived
which
are
known
regenerative
anti-inflammatory
properties,
can
enhance
process.
Furthermore,
microneedle
enable
precise
controlled
release
moieties,
growth
factors
cytokines,
site,
creating
conducive
microenvironment
repair
regeneration.
challenges
associated
with
multifaceted.
Biocompatibility
issues,
variability
skin
characteristics
among
patients,
regulatory
hurdles,
scalability,
cost
considerations,
long-term
stability,
patient
acceptance
compliance
all
present
significant
barriers
widespread
adoption
optimization
technology
clinical
practice.
Overcoming
these
will
require
collaborative
efforts
from
various
stakeholders
advance
field
address
critical
gaps
research
development.
Ongoing
focuses
on
enhancing
biocompatibility
mechanical
properties
materials,
developing
customizable
technologies
personalized
treatment
approaches,
integrating
advanced
functionalities
sensors
real-time
monitoring,
improving
engagement
adherence
through
education
support
mechanisms.
advancements
improve
management
providing
tailored
therapies
that
promote
faster
reduce
complications.
This
review
explores
current
landscape
context
management,
highlighting
both
need
be
addressed
future
perspectives
this
innovative
modality.
