Porous CeO2 Nanozyme with Visible-Light-Enhanced Catalase-Mimicking Activities by Ligand-to-Metal Charge Transfer DOI Creative Commons
Pengju Li,

Wei Yuan,

Ke Hu

et al.

iScience, Journal Year: 2025, Volume and Issue: 28(4), P. 112149 - 112149

Published: March 4, 2025

Nanozymes are promising synthetic alternatives to natural enzymes owing their unique physical and chemical properties, but improving thermocatalytic activity often involves complex procedures. This study introduces a light-induced approach enhance the catalytic of facilely prepared porous cerium oxide ( P-CeO2 ) nanozymes. Under visible light irradiation, efficiency (kcat/Km) more than doubles compared its efficiency. Spectroscopic analyses reveal that this enhancement stems from ligand-to-metal charge transfer (LMCT) band, arising peroxide species adsorbed on surface. As practical demonstration, exhibits visible-light enhanced scavenging reactive oxygen (ROS) in vitro. Overall, provides new mechanistic insights using LMCT-induced catalysis for improvement light-responsive

Language: Английский

Portable Self-Powered/Colorimetric Dual-Mode Sensing Platform Based on Multifunctional Bioconjugates for Precise On-Site Detection of Acetamiprid DOI

Chengcheng Gu,

Jianlin Liu, Ting Hou

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: 97(1), P. 928 - 935

Published: Jan. 3, 2025

Neonicotinoid insecticides have been widely applied in modern agriculture to improve crop productivity, but their residues adverse impacts on the environment and human health. Hence, address these issues, a portable self-powered/colorimetric dual-mode sensing platform was developed for simple, rapid, precise, sensitive on-site detection of acetamiprid (ATM) vegetables. In this case, multifunctional bioconjugate with specific recognition capability, excellent enzyme-like activity, loading capacity is key design. Using an Eppendorf (EP) tube as miniaturized laboratory, bioconjugates colorimetric test strip were integrated into EP tube, combined nanozyme-based self-powered (with area 1.5 × cm2), accurate ATM achieved, limits low 2.9 fg·mL–1 (self-powered method) 31.5 (colorimetry), respectively. Notably, we simulated actual insecticidal situation based field application concentration quantified pesticide The relative errors our method standard high-performance liquid chromatography 0.15% (the 1.8% high sensitivity accuracy opened up new avenue development residue analysis next generation agricultural products.

Language: Английский

Citations

3
Hybrid Enzymatic and Nanozymatic Biofuel Cells for Wearable and Implantable Biosensors DOI
Xin Luo,

Shentian Li,

Yu Wu

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118169 - 118169

Published: Jan. 1, 2025

Language: Английский

Citations

2
In-situ Nanozyme Catalytic Amplification Coupled with a Universal Antibody Orientation Strategy based Electrochemical Immunosensor for AD-Related Biomarker DOI
Xiyu Chen, Yang Huang, Shuo Yang

et al.

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 266, P. 116738 - 116738

Published: Sept. 3, 2024

Language: Английский

Citations

12
Xgboost algorithm-guided synthesis of violet phosphorus/MoAlB-MBene nanozyme for portable wireless intelligent sensing of sesamol in different varieties of sesame seeds DOI
Tao Chen, Peng Liu, Ge Yu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160080 - 160080

Published: Feb. 1, 2025

Language: Английский

Citations

1
Current trends and advances in nanozyme-enabled miRNA (bio)sensing: Classification, activity and application DOI
Esmaeil Babaei, Hewa Jalal Azeez, Shukur Wasman Smail

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113127 - 113127

Published: Feb. 1, 2025

Language: Английский

Citations

1
Machine Learning-Aided Intelligent Monitoring of Multivariate miRNA Biomarkers Using Bipolar Self-powered Sensors DOI
Jing Xu,

Xinqi Luo,

Hanxiao Chen

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 26, 2025

Breast cancer has become the most prevalent form of among women on a global scale. The early and timely diagnosis breast is utmost importance for improving survival rate patients with this disease. occurrence typically accompanied by dysregulation multiple microRNA (miRNA) expression profiles. Consequently, simultaneous detection miRNAs vital accurate cancer. In study, bipolar self-powered sensor was developed miRNA-451 miRNA-145 biomarkers based specific catalytic properties enzymes. Selenides microporous hollow cubic structure were designed prepared, which can markedly enhance enzyme load activity, as well sensitivity, due to their extensive surface area three-dimensional porous channel. platform integrated into commercial chip, signal presented in smartphone interface, thereby enabling real-time continuous monitoring. Furthermore, machine learning utilized predict miRNA detection, encompasses numerous stages, including data collection, feature extraction, model training, validation. comparison limited sensing efficiency biosensors driven biofuel cells, our achieved quantitative analysis targets, providing robust tool more comprehensive understanding function its association cancers.

Language: Английский

Citations

1
Laser‐Induced Nanozyme Biofuel Cell‐Based Self‐Powered Patch for Accelerating Diabetic Wound Healing With Real‐Time Monitoring DOI Open Access

Chengcheng Gu,

Lei Zhang, Ting Hou

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Abstract Chronic wounds are a common complication of diabetes, causing significant inconvenience, persistent pain, and economic burden to patients. Real‐time monitoring wound status timely treatment with intelligent dressings is promising way treat infection accelerate healing. However, the traditional make it difficult simultaneously maintain true state meet dynamic needs chronic wounds. Herein, multifunctional self‐powered patch (MSPP) featured antibacterial, hypoglycemic, electrical stimulation designed promote healing real‐time status, in which laser‐induced nanozyme electrodes prepared situ through laser scanning technology construct highly stable nanozyme‐based glucose biofuel cells (GBFCs). Enzymatic cascade reaction GBFCs can use local hyperglycemia produce reactive oxygen species effective antibacterial properties, reduce while generating microcurrent, further diabetes In just 10 days, patch‐treated group achieves 100% shrinkage. Meanwhile, pH sensing module MSPP also monitor fluctuations correct test results, improving accuracy. brief, construction provides solutions for developing closed‐loop biomedical systems that integrate monitoring, diagnosis, treatment.

Language: Английский

Citations

1
An Unusual Application of Multifunctional Nanozyme Derived from COF: Augmenting Chemoimmunotherapy while Attenuating Cardiotoxicity DOI
Wenxin Lv, Guangwei Jiang, Xiaojun Lin

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Abstract Enhancing therapeutic efficacy while reducing the adverse effects of drugs is crucial in cancer treatments. In this study, nitrogen‐doped carbon nanospheres are synthesized with variable enzymatic activities through pyrolysis a covalent organic framework (COF). These show increased peroxidase (POD) and oxidase (OXD) tumor microenvironment, generating reactive oxygen species (ROS) that help eliminate cells. Under normal conditions, they display catalase (CAT) superoxide dismutase (SOD) activities, promoting antioxidative protection. Their porous structure π–π/hydrophobic interactions allow for loading chemotherapeutic agent doxorubicin (DOX). The then enveloped by cell membranes, stabilizing drug load enabling targeted delivery pH‐sensitive release. This system induces ferroptosis cells activates strong anti‐tumor immune response, leading to enhanced immunotherapy breast reduced metastasis lungs. Importantly, varied nanomedicine mitigate cardiotoxicity DOX chemotherapy, improving treatment minimizing side effects. approach introduces nano‐enzyme distinctive innovative preparation, setting new standard efficient, low‐toxicity therapy.

Language: Английский

Citations

6
Heterocyclic Effect Boosted Peroxidase-like Activity of MIL(Fe) Metal-Organic Framework for Colorimetric Assay and Dye Removal DOI

Dejie Ma,

Na Li, Dangqiang Zhu

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136148 - 136148

Published: Oct. 11, 2024

Language: Английский

Citations

6
The recent research progress in the application of the nanozyme-hydrogel composite system for drug delivery DOI Creative Commons
Haichang Li, Zhenghong Liu, Pu Zhang

et al.

Drug Delivery, Journal Year: 2024, Volume and Issue: 31(1)

Published: Oct. 25, 2024

Hydrogels, comprising 3D hydrophilic polymer networks, have emerged as promising biomaterial candidates for emulating the structure of biological tissues and delivering drugs through topical administration with good biocompatibility. Nanozymes can catalyze endogenous biomolecules, thereby initiating or inhibiting in vivo processes. A nanozyme-hydrogel composite inherits functions hydrogels nanozymes, where nanozyme serves catalytic core hydrogel forms structural scaffold. Moreover, concentrate nanozymes targeted lesions binding a specific group substrates, resulting pathological microenvironment remodeling drug-penetrating barrier impairment. The also shields to prevent burst release during production reduce related toxicity. Currently, application these composites has been extended antibacterial, anti-inflammatory, anticancer, tissue repair applications. In this review, we elucidate preparation methods composites, provide compelling evidence their advantages drug delivery comprehensive overview application.

Language: Английский

Citations

4