Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 27, 2024
Abstract
Delayed
union
or
nonunion
remains
an
extremely
challenging
predicament
even
after
the
application
of
currently
available
engineering
scaffolds
for
treatment
critical‐sized
bone
defects.
The
angiogenesis
throughout
artificial
repair
scaffold
to
achieve
“angiogenic‐osteogenic
coupling”
is
regarded
as
effective
approach
solving
this
issue.
newly
formed
blood
vessels
can
accelerate
supply
oxygen
and
nutrients,
thereby
triggering
subsequent
regeneration.
Therefore,
featuring
angiogenic
microenvironment
that
promotes
cell
adhesion
migration
should
be
designed
superior
repair.
Herein,
a
magnesium
ion‐doped
hierarchical
fabricated
using
polymer
blend
system
chitosan/polyethyleneimine
with
inherent
micro‐phase
separation
complexation.
Due
microscopic
sea‐island
structure
stable
doped
ions,
behavior
underwent
significant
transformation.
Meanwhile,
pathways
related
adhesion,
migration,
are
activated,
critical
target
thrombospondin
1
upregulated.
Consequently,
capacity
augmented,
6
times
rate
attained,
human
umbilical
vein
endothelial
cells
significantly
expedited.
Eventually,
rapid
ingrowth
satisfactory
defect
approximated
in
vivo,
making
composite
promising
clinical
candidate
engineering.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(48)
Published: June 26, 2024
Abstract
The
growing
concerns
regarding
cancer
recurrence,
unpredictable
bone
deficiencies,
and
postoperative
bacterial
infections
subsequent
to
the
surgical
removal
of
tumors
have
highlighted
need
for
multifaceted
scaffolds
that
afford
tumor
therapy,
effective
vascularized
reconstruction.
However,
challenging
trilemma
has
emerged
in
realm
balance
between
achieving
appropriate
mechanical
strength,
ensuring
biocompatibility,
optimizing
a
degradation
rate
aligns
with
bone‐regenerative
rate.
Considering
these
challenges,
innovative
theragenerative
platform
is
developed
by
utilizing
3D
printing‐based
nanospikes
first
time.
This
comprises
tissue‐specific
nanospiked
hydroxyapatite
decorated
magnesium
(nMg)
adhesive
DNA
(aDNA).
incorporation
nMg
within
polylactic
acid
(PLA)
matrix
confers
photothermal
capabilities
helps
modulate
properties
improve
biocompatibility
platform.
Simultaneously,
immobilized
aDNA
contributed
enhancement
healing.
These
3D‐printed
tissue‐adhesive
platforms
exhibit
superior
offer
controlled
degradability.
Moreover,
they
enable
eradication
bacteria
osteosarcoma
through
hyperthermia
promote
angiogenesis
osteogenesis,
both
vitro
vivo.
groundbreaking
approach
poised
pave
way
fabrication
design
novel
implantable
biomaterials
integrate
therapeutic
regenerative
functions.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
Regeneration
of
diabetic
bone
defects
remains
a
formidable
challenge
due
to
the
chronic
hyperglycemic
state,
which
triggers
accumulation
advanced
glycation
end
products
(AGEs)
and
reactive
oxygen
species
(ROS).
To
address
this
issue,
we
have
engineered
bimetallic
metal–organic
framework-derived
Mn@Co3O4@Pt
nanoenzyme
loaded
with
alendronate
Mg2+
ions
(termed
MCPtA)
regulate
microenvironment
recover
osteogenesis/osteoclast
homeostasis.
Notably,
Mn
atom
substitution
in
Co3O4
nanocrystalline
structure
could
modulate
electronic
significantly
improve
SOD/CAT
catalytic
activity
for
ROS
scavenging.
By
integration
GOx-like
Pt
nanoparticles,
MCPtA
achieved
effective
multiple
cascade
performance
that
facilitated
clearance
glucose
ROS.
Furthermore,
was
encapsulated
within
glucose-responsive
hydrogel
cross-linked
via
borate
ester
bond,
termed
PAM,
evaluate
potential
composite
cranial
defect
repair
rats.
The
vitro/vivo
experiments
as
well
RNA
sequencing
analysis
demonstrated
disrupt
glucose-ROS-induced
inflammation
promoted
osteogenesis
angiogenesis,
consequence,
improving
therapeutic
effects
regeneration.
This
study
provided
crucial
insights
into
nanoenzyme-mediated
microenvironmental
regulation
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 31, 2025
Abstract
There
is
a
critical
unmet
need
to
improve
the
treatment
of
battlefield
burns.
Rapid
and
efficient
wound
protection
closure
are
essential
prevent
infections,
reduce
pain,
minimize
scarring.
This
study
introduces
portable,
field‐applicable
spray
system
designed
instantly
apply
protective
hydrogel
coating
with
therapeutic
agents
wounds
varying
sizes
shapes
for
emergency
treatments.
By
mimicking
natural
silk‐spinning
processes,
current
spray‐on
optimized
create
self‐standing,
spider‐web‐like
interwoven
structure
that
supports
tissue
adhesion,
cell
viability,
vascular
regeneration.
In
vivo
testing
in
porcine
burn
model
demonstrates
these
silk‐based
coatings,
especially
when
combined
antibiotics,
significantly
accelerated
healing
deep
partial‐thickness
burns
compared
standard
rapid
effective
performance
medical
use,
offering
an
advancement
functional
biomaterials.
Bone Research,
Journal Year:
2025,
Volume and Issue:
13(1)
Published: Feb. 14, 2025
Abstract
Infectious
bone
defects
represent
a
substantial
challenge
in
clinical
practice,
necessitating
the
deployment
of
advanced
therapeutic
strategies.
This
study
presents
treatment
modality
that
merges
mild
photothermal
therapy
hydrogel
with
pulsed
drug
delivery
mechanism.
The
system
is
predicated
on
matrix
thermally
responsive,
characteristic
defect
sites,
facilitating
controlled
and
site-specific
release.
cornerstone
this
incorporation
nanoparticles,
which
are
activated
within
temperature
range
40–43
°C,
thereby
enhancing
precision
efficacy
delivery.
Our
findings
demonstrate
response
significantly
augments
localized
agents,
mitigating
systemic
side
effects
bolstering
at
site.
synchronized
release,
cooperated
therapy,
effectively
addresses
infection
control,
promotes
regeneration.
approach
signifies
considerable
advancement
management
infectious
defects,
offering
an
effective
patient-centric
alternative
to
traditional
methods.
research
endeavors
extend
its
applicability
wider
spectrum
tissue
regeneration
scenarios,
underscoring
transformative
potential
realm
regenerative
medicine.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 18, 2025
Abstract
Contemporary
clinical
interventions
for
cartilage
injuries
focus
on
symptom
management
through
pharmaceuticals
and
surgical
procedures.
Recent
research
has
aimed
at
developing
innovative
scaffolds
with
biochemical
elements,
yet
challenges
like
inadequate
targeted
delivery
reduced
load‐bearing
capacity
hinder
their
adoption.
Inspired
by
the
spatial
gradients
of
biophysical
cues
in
native
osteochondral
tissues,
a
silk‐based
hydrogel
that
facilitates
spontaneous
dual‐gradient
formation,
including
mechanical
growth
factor
gradients,
tissue
regeneration,
is
presented.
Driven
an
electrical
field,
transitions
from
stiff
to
soft
along
anode‐to‐cathode
direction,
mimicking
anisotropic
structure
natural
tissues.
Simultaneously,
incorporated
factors
encapsulated
charged
monomers
migrate
cathode
region,
creating
another
parallel
gradient
enables
sustained
release.
This
design
maintains
bioactivity
enhances
programmable
concentration
defect
environment.
In
rabbit
model
full‐thickness
defects,
demonstrates
significant
potential
promoting
offering
promising
tool
translation.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101532 - 101532
Published: Jan. 29, 2025
Materials-mediated
piezoelectric
signals
have
been
widely
applied
in
bone
regeneration.
Collagen
is
the
most
abundant
protein
human
body,
and
native
collagen
with
complete
tertiary
structure
shows
efficient
piezoelectricity.
However,
traditional
scaffolds
are
lack
of
piezoelectricity
due
to
destruction
structure.
Here,
natural
were
prepared.
Alkali
treatment
made
scaffold
lose
The
with/without
(PiezoCol/NCol)
both
possessed
good
cytocompatibility
promoted
cell
adhesion.
After
being
implanted
subcutaneously,
NCol
almost
did
not
affect
regeneration
ultrasound
treatment.
under
treatment,
PiezoCol
new
formation
enhanced
osteogenic
differentiation,
angiogenesis,
neural
meaning
that
endows
satisfactory
promotion
for
Meanwhile,
can
also
accelerate
without
which
should
be
attributed
daily
exercise-caused
weak
stimulation.
Further,
proteomic
analysis
revealed
mechanism
by
tissue
via
mainly
upregulating
PI3K-Akt
signaling
pathway.
This
study
provides
a
strategy
enhance
osteoinduction
maintaining
intrinsic
