Gas Empowered Dual‐Cascade Strategy for Augmented Single‐Atom Nanotherapies DOI
Yong Liu,

Xiao‐Qiong Li,

Qiao Yu

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Abstract Single‐atom nanotherapies have received numerous attention in malignant oncotherapy. However, the insufficient enzyme substrate and upregulation of heat shock proteins during therapeutic interventions are seldom concurrently noticed. Herein, a novel gas empowered dual‐cascade synergistic treatment strategy is demonstrated with domino effect, which can sequentially reinforce single‐atom nanozyme (SAzyme)‐based enzymatic therapeutics mild photothermal therapy (PTT) (< 45 °C). In proof‐of‐concept study, Fe single atom (Fe/SAzyme) loaded hydrogen sulfide (H 2 S) donor NaHS developed for HSPs‐silencing mediated PTT. The generated H S suppresses catalase activity to achieve “intracellular O conservation”, thereby furnishing Fe/SAzyme produce abundant cytotoxic hydroxyl radicals (·OH) augmented therapeutics. Then, excess ·OH induced mitochondrial dysfunction blocks adenosine triphosphate (ATP) energy supply realize cellular remodeling, hinders overexpression HSPs enhances PTT both vitro vivo. Consequently, gas‐triggered achieves S/·OH/mitochondrial endowing SAzymes maximum antitumor efficacy via combined This dual‐cascaded gas/enzymatic/mild oncotherapy not only exhibits new pathway gas‐facilitated PTT, but also offers valuable paradigm application “1 + 1 > 3” multimodal tumor therapy.

Language: Английский

Acid‐Responsive Nanoregulators Elicit Hydrogen Sulfide‐Mediated Tumor Oxygenation and Selective Sonosensitization for Hypoxic Tumors DOI Open Access
Qi Yu, Qin Zhang, Yujing Zhou

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Oxygen (O 2 ) tension within a tumor is considered hallmark of sonodynamic therapy (SDT). Herein, multifunctional nanoregulators, CMCS‐Au‐SrS (CAS), are reported, which assembled by carboxymethyl chitosan(CMCS) tethered gold nanoclusters (Au NCs) as sonosensitizers and sulfurate donors strontium sulfide nanoparticles (SrS NPs), to evoke selective SDT in hypoxic tumors. CAS possess tumor‐acidity responsiveness form large‐size aggregated Au NCs with shortened bandgap so that effectively induce powerful reactive oxygen species generation. On the other hand, acidity triggers degradation SrS NPs release hydrogen (H S), evoking oxygenation overcome hypoxia. This junction accelerated sonosensiting ability boosts amplified efficacy. More importantly, specific glycolysis induced acidification leads selectively accumulated cancer cells, further guaranteeing execution advanced therapeutic manners. Additionally, doping Nd 3+ endows second near‐infrared fluorescence facilitate vivo tracing property good tissue penetration (up 6 mm). strategy may play pioneering role develop theranostic reagents improved enrichment capacity enhanced hypoxia

Language: Английский

Citations

3
Bacterial derivatives mediated drug delivery in cancer therapy: a new generation strategy DOI Creative Commons
Muhammad Ijaz,

Ikram Hasan,

Tamoor Hamid Chaudhry

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Aug. 24, 2024

Cancer is measured as a major threat to human life and leading cause of death. Millions cancer patients die every year, although burgeoning number researchers have been making tremendous efforts develop medicine fight against cancer. Owing the complexity heterogeneity cancer, lack ability treat deep tumor tissues, high toxicity normal cells, it complicates therapy However, bacterial derivative-mediated drug delivery has raised interest in overcoming restrictions conventional chemotherapy. In this review, we show various examples tumor-targeting bacteria derivatives for anticancer drugs. This review also describes advantages limitations delivering treatment drugs under regulated conditions employing these their membrane vesicles. study highlights substantial potential clinical translation bacterial-based carriers, improve work with other modalities, provide more powerful, dependable, distinctive therapy.

Language: Английский

Citations

12
Engineering Strain‐Defects to Enhance Enzymatic Therapy and Induce Ferroptosis DOI Open Access

Shiliang Cao,

Shuming Dong, Lili Feng

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Abstract The effect of mimetic enzyme catalysis is often limited by insufficient activity and a single therapy not sufficient to meet the application requirements. In this study, multifunctional nanozyme, MMSR‐pS‐PEG, designed fabricated modifying poly (ethylene glycol) grafted phosphorylated serine (pS‐PEG) on mesoporous hollow MnMoO x spheres, followed loading sorafenib (SRF) into pores. Strain engineering‐induced oxygen defects endow nanozyme with enhanced dual‐enzymatic mimic catalase oxidase‐like activities, which catalyze conversion endogenous H 2 O subsequently superoxide ions in acidic tumor microenvironment. Moreover, as an n‐type semiconductor, generates reactive species separating electrons holes upon ultrasonic irradiation simultaneously deplete glutathione holes, thereby further augmenting its catalytic effect. As ferroptosis inducer, SRF restrains system c − indirectly inhibits synthesis, synergistically interacting stimulate promoting lipid peroxidation accumulation downregulation peroxidase 4. These results provide valuable insights design enzymatic high performance highlight promising approach for synergism therapy.

Language: Английский

Citations

8
A hyaluronic acid modified advanced nanoagent activated by tumor microenvironment enables a reciprocal dual-modality therapy DOI
Jiaxuan Li,

Zelong Chen,

Zhichao Pei

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159884 - 159884

Published: Feb. 1, 2025

Language: Английский

Citations

1
Direct Visualization of Self-Mineralized Biohybrid-Triggered Apoptosis–Ferroptosis Synergistic Tumor Therapy by Cryo-Soft X-ray Tomography DOI
Zheng Dang, Yuting Wang, Yong Guan

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Bionano robots have been recognized as a tumor-selective and effective platform for therapeutic outcomes they synergize the merits of living organisms nanoparticles. Here, we construct self-mineralized system (denoted SO@FeS) by employing facultative anaerobic bacterium Shewanella oneidensis MR-1 to biosynthesize FeS NPs cancer therapy with dual cell death pathways. Biogenic are embedded into surface inherent photothermal conversion ability low crystallinity tend simultaneously release Fe2+ hydrogen sulfide (H2S) in an acidic environment. As result, obtained SO@FeS hybrid can couple versatility nanoparticles respiration tumor-targeting capacities bacterium, ultimately leading collaborative clearance tumor cells. Specifically, cryo-soft X-ray tomography (cryo-SXT) is near-native 3D imaging modality that directly displays trafficking pathway More importantly, cryo-SXT captures maps SO@FeS-initiated ferroptosis apoptosis, evidenced remodeling cytoplasmic organelles. This work offers valuable theoretical insights from perspective organelle morphology, links subcellular reorganization pathways, facilitates design nanoplatforms integrate multiple therapies.

Language: Английский

Citations

0
Natural mineral drugs inspired functional nanomaterials: design, synthesis, and biomedical applications DOI

Yefan Duan,

Xiangdong Ding,

Elizat Ablikim

et al.

Journal of the American Ceramic Society, Journal Year: 2025, Volume and Issue: unknown

Published: May 5, 2025

Abstract Functional nanomaterials inspired by natural minerals hold significant promise for biomedical applications, attributed to their distinctive physicochemical characteristics. This study explores the impact of contemporary technology on advancement nanoscale transformation mineral drugs, taking into account historical applications. Through “top‐down” and “bottom‐up” synthesis strategies, size morphology are controlled precisely optimize bioavailability efficacy. In realm these have proven be highly effective in both standalone combined therapies, notably enhancing targeted drug delivery, magnetic resonance imaging, photothermal therapy. Furthermore, article delves cutting‐edge delivery methods that leverage extracellular space. These anticipated overcome constraints imposed blood‐brain barrier open new avenues treating brain diseases. The extensive utilization renowned exceptional biosafety therapeutic effectiveness, establishes a robust foundation integrating nanotechnology. integration holds great advancing clinical translation drugs. Future research must delve deeper evaluating stability potential use materials within broad spectrum

Language: Английский

Citations

0
Current progress in the regulation of endogenous molecules for enhanced chemodynamic therapy DOI Creative Commons
Jun Wang, Yina Liu, Tingting Cui

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(26), P. 9915 - 9926

Published: Jan. 1, 2024

A comprehensive summary of how different endogenous molecules' metabolic processes (including H 2 O , iron, lactate, GSH, and lipid metabolisms) impact Fenton chemistry is provided in this perspective for advancing chemodynamic therapy against cancer.

Language: Английский

Citations

3
Gas Empowered Dual‐Cascade Strategy for Augmented Single‐Atom Nanotherapies DOI
Yong Liu,

Xiao‐Qiong Li,

Qiao Yu

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Abstract Single‐atom nanotherapies have received numerous attention in malignant oncotherapy. However, the insufficient enzyme substrate and upregulation of heat shock proteins during therapeutic interventions are seldom concurrently noticed. Herein, a novel gas empowered dual‐cascade synergistic treatment strategy is demonstrated with domino effect, which can sequentially reinforce single‐atom nanozyme (SAzyme)‐based enzymatic therapeutics mild photothermal therapy (PTT) (< 45 °C). In proof‐of‐concept study, Fe single atom (Fe/SAzyme) loaded hydrogen sulfide (H 2 S) donor NaHS developed for HSPs‐silencing mediated PTT. The generated H S suppresses catalase activity to achieve “intracellular O conservation”, thereby furnishing Fe/SAzyme produce abundant cytotoxic hydroxyl radicals (·OH) augmented therapeutics. Then, excess ·OH induced mitochondrial dysfunction blocks adenosine triphosphate (ATP) energy supply realize cellular remodeling, hinders overexpression HSPs enhances PTT both vitro vivo. Consequently, gas‐triggered achieves S/·OH/mitochondrial endowing SAzymes maximum antitumor efficacy via combined This dual‐cascaded gas/enzymatic/mild oncotherapy not only exhibits new pathway gas‐facilitated PTT, but also offers valuable paradigm application “1 + 1 > 3” multimodal tumor therapy.

Language: Английский

Citations

0