Nanoplatforms Targeting Intrinsically Disordered Protein Aggregation for Translational Neuroscience Applications DOI Creative Commons
Chih Hung Lo,

Lenny Yi Tong Cheong,

Jialiu Zeng

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(10), P. 704 - 704

Published: May 8, 2025

Intrinsically disordered proteins (IDPs), such as tau, beta-amyloid (Aβ), and alpha-synuclein (αSyn), are prone to misfolding, resulting in pathological aggregation propagation that drive neurodegenerative diseases, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), Parkinson’s (PD). Misfolded IDPs aggregate into oligomers fibrils, exacerbating progression by disrupting cellular functions the central nervous system, triggering neuroinflammation neurodegeneration. Furthermore, aggregated exhibit prion-like behavior, acting seeds released extracellular space, taken up neighboring cells, have a propagating pathology across different regions of brain. Conventional inhibitors, small molecules, peptides, antibodies, face challenges stability blood–brain barrier penetration, limiting their efficacy. In recent years, nanotechnology-based strategies, multifunctional nanoplatforms or nanoparticles, emerged promising tools address these challenges. These leverage tailored designs prevent remodel reduce associated neurotoxicity. This review discusses advances designed target Aβ, αSyn aggregation, with focus on roles reducing We examine critical aspects nanoplatform design, choice material backbone targeting moieties, which influence interactions IDPs. also highlight key mechanisms interaction between inhibit redirect cascade towards nontoxic, off-pathway species, disrupt fibrillar structures soluble forms. further outline future directions for enhancing IDP clearance, achieving spatiotemporal control, improving cell-specific targeting. nanomedicine strategies offer compelling paths forward developing more effective targeted therapies diseases.

Language: Английский

Recent Progress in Nanomedicine for the Diagnosis and Treatment of Alzheimer’s Diseases DOI

Han Yang,

Haozhe Tan,

Haifei Wen

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(50), P. 33792 - 33826

Published: Dec. 3, 2024

Alzheimer's disease (AD) is a neurodegenerative that causes memory loss and progressive permanent deterioration of cognitive function. The most challenging issue in combating AD its complicated pathogenesis, which includes the deposition amyloid β (Aβ) plaques, intracellular hyperphosphorylated tau protein, neurofibrillary tangles (NFT), etc. Despite rapid advancements mechanistic research drug development for AD, currently developed drugs only improve ability temporarily relieve symptoms but cannot prevent AD. Moreover, blood–brain barrier (BBB) creates huge to delivery brain. Therefore, effective diagnostic tools treatments are urgently needed. In recent years, nanomedicine has provided opportunities overcome challenges limitations associated with traditional diagnostics or treatments. Various types nanoparticles (NPs) play an essential role diagnosis treatment acting as carriers targeting bioavailability across/bypass BBB directly on lesions. This review categorizes different NPs summarizes their applications It also discusses clinical explores latest developments prospects

Language: Английский

Citations

4
Inspired by “Trojan Horse” Effect to Construct a Novel Chrome‐Free Tanning Agent—Achieving the Integration of Tanning‐Dyeing and Personal Thermal Management DOI Open Access
Ruilong Li, Longfang Ren, Xin Sun

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Among human deaths induced by abnormal weather, ≈95% are caused low temperatures. Personal thermal management (PTM) is more energy efficient than traditional central heating. Inspired “Trojan War” and combined with the advantages of natural leather, a novel chrome‐free tanning agent (OMFA) Horse” effect constructed based on ZrOCl 2 ‐assisted oxidation mineral fulvic acid. It innovatively realizes “One Stone Three Birds” integrated strategy tanning, dyeing PTM leather preparation. OMFA, just like Trojan horse, brings Zr 4+ into all hierarchy leather; as result, OMFA firmly fixed in collagen fibers chemical cross‐linking. The shrinking temperature resultant reaches 82.7 °C color difference less 0.2, showcasing good hydrothermal stability fastness. Moreover, solar absorption rate tanned 78.3%. In outdoor test, surface higher 20.9 3.4 ambient at noon evening, respectively. This study first time to confer properties onto means tanning. work expected replace chrome agent, reduce dye wastewater discharge, realize clean utilization.

Language: Английский

Citations

0
Phototherapy via Modulation of β‐Amyloid in Combating Alzheimer's Disease DOI Creative Commons
Yunhua Zhang,

Chengyuan Qian,

Yuncong Chen

et al.

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

ABSTRACT Alzheimer's disease (AD) is one of the most prevalent forms neurodegenerative disease. Although some controversy exists, β‐amyloid peptide (Aβ) recognized to play an essential role in pathophysiology AD. The Aβ species are known exist various forms, including soluble monomers, oligomers, and insoluble aggregates. Despite extensive efforts regulate aggregation, no successful medications have been developed date. Among strategies for AD treatment, phototherapy, photodynamic therapy (PDT), photothermal (PTT), photopharmacology, photobiomodulation (PBM) attracted increased attention because spatiotemporal controllability. Representative examples PDT, PTT, PBM discussed terms inhibitory mechanism, unique properties materials, design phototherapy modulators. major challenges against addressed promising prospects proposed. It concluded that noninvasive light‐assisted approaches will become a strategy intensifying modulation aggregation or promoting clearance thus facilitating treatment.

Language: Английский

Citations

0
Nano-Collision Electrochemistry for Real-Time Monitoring of Amyloid-β Oligomerization and Rapid Screening of Degrading Drugs DOI
Jinrong Liu, Luan Chen, Zhiling Zhang

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Toxic oligomers of amyloid-β (Aβ) are important in the pathology Alzheimer's disease (AD), and degradation Aβ (AβO) brain is considered a promising strategy for drug development. However, conventional screening techniques face challenges rapid real-time assessment AβO. Here, we report simple reliable nanocollision electrochemical method based on silver nanoparticles (AgNPs) "tagging" that can situ monitor oligomerization screen potential AβO-degrading drugs. The differences collision signals between AgNPs-Aβ complexes AgNPs were compared to achieve identification with different aggregation degrees. effect following addition drugs be quickly evaluated by recovery frequency (f, number peaks per unit time), which effective if f > 0.15. Degradation efficiency was further quantified using current lifetimes (τ, time required decay 1/e original), percentage τ ≤ 10 ms. practicability tested Aβ-degrading protease several small molecules, confirming offering novel accelerate development AD treatment.

Language: Английский

Citations

0
Nanoplatforms Targeting Intrinsically Disordered Protein Aggregation for Translational Neuroscience Applications DOI Creative Commons
Chih Hung Lo,

Lenny Yi Tong Cheong,

Jialiu Zeng

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(10), P. 704 - 704

Published: May 8, 2025

Intrinsically disordered proteins (IDPs), such as tau, beta-amyloid (Aβ), and alpha-synuclein (αSyn), are prone to misfolding, resulting in pathological aggregation propagation that drive neurodegenerative diseases, including Alzheimer’s disease (AD), frontotemporal dementia (FTD), Parkinson’s (PD). Misfolded IDPs aggregate into oligomers fibrils, exacerbating progression by disrupting cellular functions the central nervous system, triggering neuroinflammation neurodegeneration. Furthermore, aggregated exhibit prion-like behavior, acting seeds released extracellular space, taken up neighboring cells, have a propagating pathology across different regions of brain. Conventional inhibitors, small molecules, peptides, antibodies, face challenges stability blood–brain barrier penetration, limiting their efficacy. In recent years, nanotechnology-based strategies, multifunctional nanoplatforms or nanoparticles, emerged promising tools address these challenges. These leverage tailored designs prevent remodel reduce associated neurotoxicity. This review discusses advances designed target Aβ, αSyn aggregation, with focus on roles reducing We examine critical aspects nanoplatform design, choice material backbone targeting moieties, which influence interactions IDPs. also highlight key mechanisms interaction between inhibit redirect cascade towards nontoxic, off-pathway species, disrupt fibrillar structures soluble forms. further outline future directions for enhancing IDP clearance, achieving spatiotemporal control, improving cell-specific targeting. nanomedicine strategies offer compelling paths forward developing more effective targeted therapies diseases.

Language: Английский

Citations

0