Reactive Oxygen Species-Responsive Pillararene-Embedded Covalent Organic Frameworks with Amplified Antimicrobial Photodynamic Therapy for the Targeted Elimination of Periodontitis Pathogens

Nano Letters, Journal Year: 2024, Volume and Issue: 24(43), P. 13708 - 13717

Published: Oct. 17, 2024

Reactive oxygen species (ROS)-responsive drug delivery systems possess immense potential for targeted and controlled release of therapeutics. However, the rapid responsiveness to ROS sustained antibacterial drugs are often limited by challenging microenvironment periodontitis. Integrating ROS-responsive with photocatalytic technologies presents a strategic approach overcome these limitations. Herein, pillararene-embedded covalent organic framework (PCOF) incorporating prodrug thioacetal (TA) has been developed treat This drug-loaded nanoplatform, namely TA-loaded PCOF, utilizes self-amplifying property enhance therapeutic efficacy. PCOFs demonstrate exceptional photosensitivity generation capabilities when employed as carriers. When exposed ROS, TA within nanoplatform was activated cleaved into cinnamaldehyde (CA), highly potent compound. By leveraging visible light activate site-specific infection targeting, PCOF effectively alleviated periodontitis, thereby advancing field systems.

Language: Английский

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Nanoparticles Designed Based on the Blood‐Brain Barrier for the Treatment of Cerebral Ischemia‐Reperfusion Injury

Small, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Cerebral ischemia-reperfusion injury (CI/RI) is currently considered a significant factor affecting the prognosis of ischemic stroke. The blood-brain barrier (BBB) plays multiple roles in treatment ofCI/RI. BBB leakage allows bloodborne toxins to exacerbate stroke pathology. Yet as physiological that separates blood from brain, also poses obstacle therapeutic drug delivery. Therefore, it essential consider both crossing and repairing process CI/RI. Leveraging exceptional benefits nanoparticles (NPs) for penetration targeted repair, numerous NPs are developed promising delivery platforms. Considering complex role CI/RI, this review delves into strategies designing cross BBB, focusing on peptide-modified NPs, cell-mediated cell membrane-derived BBB-modulating NPs. Additionally, summarizes design targeting endothelial cells (ECs), astrocytes, those aimed at regulating microenvironment repair BBB. On basis, reveals prospects challenges designed around CI/RI treatment. And highlights need combine permeability promotion nanoparticle based achieve more effective

Language: Английский

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Inhibiting Chemotherapy Immune Tolerance and Reversing Tumor Microenvironment by Macrophage‐Targeted Nanohybrid Systems for Enhancing Tumor Chemo‐Immunotherapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Chemotherapy combined with immunotherapy (chemo‐immunotherapy) has emerged as a critical strategy in tumor treatment. However, chemotherapy induced immune tolerance and the immunosuppressive microenvironment limit its effectiveness. Secondary necrosis can generate additional immunogenic substances, enhancing immunogenicity of cells, but macrophage‐mediated clearance apoptotic cells inhibits occurrence secondary necrosis. In this study, tumor‐associated macrophage (TAM)‐targeting nanohybrid system, SC@P@U, is designed by combining poly (lactic‐co‐glycolic acid) (PLGA)‐loaded MerTK inhibitor UNC2025 (P@U) saccharomyces cerevisiae‐derived β‐glucan (SC shell). This system specifically targets TAMs, preventing them from clearing inhibiting their polarization into immune‐suppressive M2 macrophages. More importantly, it activates STING pathway, further stimulating dendritic initiating T cell‐mediated responses. vivo experiments demonstrated that when paclitaxel (PTX), significantly suppressed growth, activated anti‐tumor immunity, and, used conjunction checkpoint αPD‐1, markedly enhanced effect. overcomes traditional chemo‐immunotherapy, reverses microenvironment, offers promising approach to

Language: Английский

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Collagenase Degradable Biomimetic Nanocages Attenuate Porphyromonas gingivalis Mediated Neurocognitive Dysfunction via Targeted Intracerebral Antimicrobial Photothermal and Gas Therapy

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Porphyromonas gingivalis (P.g.), a pathogen linked to periodontitis, is reported be associated with severe neurocognitive dysfunction. However, there are few reports focusing on improving neurological function in the brain by eliminating P.g.. Therefore, we developed core-shell nanocomposite for targeted intracerebral P.g. clearance and ameliorating impairments, [email protected], consisting of platinum nanoparticles (Pt NPs) encapsulated within Au nanocages (Pt-Au) as core shell made collagen macrophage membranes from pretreated (C-P.g.-MM). This design enhanced nanocomposite's ability cross blood-brain barrier (BBB) specifically target through coating P.g.-MM. [email protected] depended neutralize excessive collagenase P.g., promoting its directed migration toward exhibited excellent photothermal effects under near-infrared (NIR) laser irradiation, while Pt NPs also provided an efficient antibacterial gas therapy generating oxygen expose anaerobic As result, contributed synergistic significantly reduced mediated dysfunction periodontitis mice induced oral infection. Based insights transcriptome sequencing analysis, anti-P.g. activity facilitated transition microglia M1 M2 phenotype stimulating PI3K-Akt pathway reducing neuronal damage Wnt/β-catenin pathway.

Language: Английский

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β‐1,3 Glucan Microparticles & Nanoparticles: Fabrication Methods & Applications in Immunomodulation & Targeted Drug Delivery

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Abstract Innate immune cells such as macrophages and dendritic play major roles in the progression of many cancerous, fibrotic, autoimmune diseases, often due to environmental cues that skew these toward a phenotype progresses or exacerbates disease state. As such, growing focus treating diseases is placed on exploiting high plasticity modify reverse their pro‐disease phenotypes using immunomodulatory materials. β‐1,3 glucans are one type material has exhibited diverse effects cells, including mitigation reversal adverse dysregulated cells. In this review, we outline various fabrication techniques produce glucan‐derived microparticles nanoparticles discuss particle properties can be obtained by tuning glucan chemistry, method, formulation components. Furthermore, applications particles highlighted with cell targeting, modulation, delivery small molecule macromolecular therapeutics.

Language: Английский

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Macrophage-Hitchhiked, Effervescence-Induced Nanoemulsions for Enhanced Oral Chemotherapy and Immunotherapy: Impact on Absorption Route

Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 123019 - 123019

Published: Dec. 15, 2024

Language: Английский

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Janus-Adhesive ionogels for wearable Real-Time monitoring and prevention of infantile meningitis

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156197 - 156197

Published: Sept. 1, 2024

Language: Английский

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