Recent advance development in pillar[5]arene-based nanomaterials for cancer therapy

Chemical Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

In this review, we summarize five different types of pillar[5]arene-based nanomaterials and their applications in chemotherapy, photodynamic therapy, photothermal multimodal synergistic therapy for tumors.

Language: Английский

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3D printing of multifunctional hydrogel scaffolds based on recombinant collagen for bile duct repair

APL Materials, Journal Year: 2025, Volume and Issue: 13(2)

Published: Feb. 1, 2025

Bile duct injuries remain a significant clinical challenge following hepatobiliary surgeries. Recently, 3D-printed tubular scaffolds have shown promise as effective solutions for bile tissue repair. This study presents novel bi-layered scaffold, fabricated using advanced three-dimensional printing technology. The inner layer of this scaffold is constructed from poly(ε-caprolactone) methacrylate (PCLMA), which imparts high mechanical strength. outer composed biocompatible methacrylated recombinant type I collagen (rColMA) and ε-poly(L-lysine)-methacrylamide (EPLMA), providing excellent antibacterial properties. In addition, encapsulated interleukin-6-loaded liposomes (IL-6@Lip) are incorporated into the to further promote regeneration. innovative design creates an optimal microenvironment growth differentiation bone marrow mesenchymal stem cells (BMSCs) duct-like cells. These differentiated contribute regeneration, evidenced by expression key markers, including CK7, CK19, AQP1, AE2, CX43. rColMA/EPLMA/IL-6@Lip hydrogel in significantly enhances BMSC proliferation their epithelial Furthermore, vivo experiments show that PCLMA//rColMA/EPLMA/IL-6@Lip does not induce stasis. novel, pre-differentiated active offers valuable insights regeneration replacement research.

Language: Английский

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Study on synergistic mechanism of Cu-TCPP@MnO2 composites for photothermal/photodynamic/chemodynamic treatment of infected wound healing

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162334 - 162334

Published: April 1, 2025

Language: Английский

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Regulating Enol-to-Keto Tautomerization of Pillararene-Based Conjugated Macrocycle Polymers for H₂O₂ Photosynthesis

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: April 10, 2025

Porous organic polymers have emerged as promising materials for energy conversion, pollutant adsorption, and heterogeneous catalysis because of their tunable pore structures high surface areas. However, most porous are still limited by insufficient conjugation inefficient electron-hole separation, hindering the tunability photoelectric properties overall functionality. By integrating macrocyclic compounds a new building block, which feature electron-rich cavities rigid ring structures, into polymer network, resulting conjugated macrocycle expected to provide an innovative approach enrich functionalities polymers. Herein, enaminone-based pillararene photocatalyst, TpAP[5], is constructed covalently linking functionalized pillar[5]arene through Schiff base condensation efficient photocatalytic reactions. This material demonstrates exceptional performance in production hydrogen peroxide, achieving rate 2343 μmol g-1 h-1. In-depth investigations reveal that incorporation pillararenes enables synergistic water oxidation oxygen reduction reactions significantly enhances catalyst stability regulating molecular tautomerization. work opens avenues designing high-performance multifunctional with significant potential clean conversion.

Language: Английский

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Review of light activated antibacterial nanomaterials in the second biological window

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 15, 2025

Language: Английский

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A Microenvironment‐Responsive Graphdiyne‐Iron Nanozyme Hydrogel with Antibacterial and Anti‐Inflammatory Effect for Periodontitis Treatment

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Periodontitis is a chronic inflammatory disease caused by dental plaque, which leads to tooth loosening and shifting or even loss. Current treatments, including mechanical debridement antibiotics, often fail eradicate recalcitrant biofilms mitigate excessive inflammation. Moreover, these interventions can disrupt the oral microbiome, potentially compromising long-term treatment outcomes. To address limitations, an injectable nanoenzyme hydrogel composed of dopamine (DA)-modified hyaluronic acid (HA) scaffold graphdiyne-iron (GDY-Fe) complex, named GDY-Fe@HA-DA, exhibits excellent tissue adhesion, self-healing, antibacterial properties, biocompatibility. Under near-infrared laser irradiation, GDY-Fe@HA-DA effectively eradicates variety pathogens, Escherichia coli, Staphylococcus aureus, Porphyromonas gingivalis, through synergistic combination chemodynamical photothermal therapies. The hydrogel's efficacy further validated in both bacterial-infected skin wounds rat periodontitis models. It alleviates environment promotes wound healing periodontal recovery. This findings highlight potential as promising therapeutic material for other injuries.

Language: Английский

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Tunable Nano-Supramolecules Based on Cucurbiturils for Near-Infrared Phosphorescence Imaging

Nano Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

Nano-supramolecules based on artificial macrocycles can not only regulate assembly morphology but also boost phosphorescence resonance energy transfer (PRET). Herein, a water-soluble supramolecule was constructed from the hyaluronic acid-modified bromophenylpyridinium (HAPY), cucurbit[

Language: Английский

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