Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
137(1)
Published: Sept. 21, 2024
Abstract
Phototheranostics
is
growing
into
a
sparking
frontier
in
disease
treatment.
Developing
single
molecular
species
synchronously
featured
by
powerful
absorption
capacity,
superior
second
near‐infrared
(NIR‐II)
fluorescence
and
prominent
photothermal
conversion
ability
highly
desirable
for
phototheranostics,
yet
remains
formidably
challenging.
In
this
work,
we
propose
design
philosophy
that
the
integration
of
noncovalent
conformational
locks
(NoCLs)
with
aggregation‐induced
emission
(AIE)
formulation
able
to
boost
multiple
photophysical
properties
efficient
phototheranostics.
The
introduction
NoCLs
skeleton
conformation‐locking
feature
center
architecture
indeed
elevates
structural
planarity
rigidity,
which
simultaneously
promotes
capacity
bathochromic‐shifts
wavelength
centered
NIR‐II
region.
Meanwhile,
AIE
tendency
mainly
originated
from
flexibly
propeller‐like
geometry
at
ends
eventually
endows
molecule
satisfactory
intensity
aggregates.
Consequently,
utilizing
optimized
molecule,
unprecedented
performance
on
fluorescence‐photoacoustic‐photothermal
trimodal
imaging‐guided
photothermal‐chemo
synergistic
therapy
demonstrated
precise
tumor
diagnosis
complete
ablation.
Polymers,
Journal Year:
2025,
Volume and Issue:
17(9), P. 1258 - 1258
Published: May 5, 2025
Conjugated
polymers
(CPs)
have
emerged
as
promising
candidates
for
photodynamic
therapy
(PDT)
in
cancer
treatment
due
to
their
high
fluorescence
quantum
yield,
excellent
photostability,
and
remarkable
reactive
oxygen
species
(ROS)
generation
capability.
This
review
systematically
summarizes
molecular
design
strategies
augment
CP
photosensitivity
efficiency,
including:
(1)
constructing
donor–acceptor
(D-A)
alternating
structures,
(2)
incorporating
aggregation-induced
emission
(AIE)
moieties,
(3)
employing
heavy-atom
effects,
(4)
designing
hyperbranched
architectures.
In
addition,
considering
the
limitations
of
monotherapy
like
tumor
heterogeneity,
we
will
further
discuss
synergistic
CP-mediated
PDT
combination
with
other
therapeutic
modalities,
including
photothermal
(PTT)-PDT,
immunotherapy-PDT,
chemotherapy-PDT,
Chemiluminescence
(CL)-PDT,
diagnostic
technology-PDT,
chemodynamic
(CDT)-PDT.
These
multimodal
approaches
leverage
complementary
mechanisms
achieve
enhanced
eradication
efficacy.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
64(1)
Published: Sept. 21, 2024
Phototheranostics
is
growing
into
a
sparking
frontier
in
disease
treatment.
Developing
single
molecular
species
synchronously
featured
by
powerful
absorption
capacity,
superior
second
near-infrared
(NIR-II)
fluorescence
and
prominent
photothermal
conversion
ability
highly
desirable
for
phototheranostics,
yet
remains
formidably
challenging.
In
this
work,
we
propose
design
philosophy
that
the
integration
of
noncovalent
conformational
locks
(NoCLs)
with
aggregation-induced
emission
(AIE)
formulation
able
to
boost
multiple
photophysical
properties
efficient
phototheranostics.
The
introduction
NoCLs
skeleton
conformation-locking
feature
center
architecture
indeed
elevates
structural
planarity
rigidity,
which
simultaneously
promotes
capacity
bathochromic-shifts
wavelength
centered
NIR-II
region.
Meanwhile,
AIE
tendency
mainly
originated
from
flexibly
propeller-like
geometry
at
ends
eventually
endows
molecule
satisfactory
intensity
aggregates.
Consequently,
utilizing
optimized
molecule,
unprecedented
performance
on
fluorescence-photoacoustic-photothermal
trimodal
imaging-guided
photothermal-chemo
synergistic
therapy
demonstrated
precise
tumor
diagnosis
complete
ablation.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(21), P. 27075 - 27086
Published: May 16, 2024
Multifaceted
nanoplatforms
integrating
fluorescence
imaging
and
chemotherapy
have
garnered
acknowledgment
for
their
potential
potency
in
cancer
diagnosis
simultaneous
situ
therapy.
However,
some
drawbacks
remain
traditional
organic
photosensitizers,
such
as
poor
photostability,
short
excitation
wavelength,
shallow
penetration
depth,
which
will
greatly
lower
the
treatment
efficiency.
Herein,
we
present
lipid-encapsulated
two-photon
active
aggregation-induced
emission
(AIE)
luminogen
paclitaxel
(PTX)
nanoparticles
(AIE@PTX
NPs)
with
bright
red
emission,
excellent
good
biocompatibility.
The
AIE@PTX
NPs
exhibit
dual
functionality
probes
visualizing
blood
vessels
tumor
structures,
achieving
depth
up
to
186
120
μm,
respectively.
Furthermore,
growth
of
HeLa-xenograft
model
can
be
effectively
prohibited
after
imaging-guided
PTX-induced
chemotherapy,
shows
great
clinical
application
cell
treatment.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
13(22)
Published: May 4, 2024
Near-infrared-II
(NIR-II)
fluorescence
imaging
is
pivotal
in
biomedical
research.
Organic
probes
exhibit
high
potential
clinical
translation,
due
to
advantages
such
as
precise
structure
design,
low
toxicity,
and
post-modifications
convenience.
In
related
preparation,
enhancement
of
NIR-II
tail
emission
from
NIR-I
dyes
an
efficient
method.
particular,
the
promotion
twisted
intramolecular
charge
transfer
(TICT)
relevant
a
convenient
protocol.
However,
present
TICT-type
still
show
disadvantages
relatively
emission,
large
particle
sizes,
or
limited
choice
dyes,
etc.
Herein,
synthesis
stable
small-sized
polymer
fluoroprobes
(e.g.,
7.2
nm),
integrating
TICT
Förster
resonance
energy
process
synergistically
enhance
reported.
Strong
enhanced
emissions
can
be
obtained
various
lanthanide
elements
twelvefold
at
1250
nm
Nd-DTPA/IR-808
sample).
The
fluorophore
provides
high-resolution
angiography,
with
high-contrast
on
middle
cerebral
artery
occlusion
model
mice
for
distinguishing
occlusion.
rapidly
excreted
kidney
(urine
≈65%
within
4
h)
normal
exhibits
long-term
renal
retention
acute
injury
mice,
showing
applications
prognosis
diseases.
This
development
effective
strategy
design
synthesize
fluoroprobes.
Chemistry of Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 9, 2024
Due
to
the
strong
light
trapping
ability,
good
biocompatibility,
and
easily
regulated
molecular
structure,
conjugated
polymers
are
becoming
a
promising
tool
for
phototheranostics
of
tumors,
which
can
achieve
both
precise
diagnosis
efficient
therapeutics.
Of
particular
interest
is
polymer-based
theranostic
agents
applying
second
near-infrared
(NIR-II)
window
(1000–1700
nm),
exhibit
great
potential
clinical
applications
on
account
extremely
long
wavelength.
Herein,
basic
mechanism,
advances
in
recent
6
years,
perspectives
polymer
NIR-II
toward
tumor
discussed
successively.
First,
mechanisms
most
widely
employed
modalities
presented.
In
view
heat
generation
property
under
photoexcitation,
fluorescence
imaging
(FLI)-guided
photothermal
therapy
(PTT)
photoacoustic
(PAI)-guided
PTT.
Then,
related
FLI-guided
PTT
technology,
PAI-guided
multimodel
theranostics
introduced.
Finally,
development
illustrated
practical
application
simultaneously
situ
tumor.
Journal of Innovative Optical Health Sciences,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 15, 2024
The
fluorescence
imaging
(FLI)
in
the
second
near-infrared
window
(NIR-II,
1000–1700[Formula:
see
text]nm)
has
attracted
considerable
attention
past
decade.
In
contrast
to
conventional
NIR-I
excitation
(808[Formula:
text]nm/980[Formula:
text]nm),
FLI
with
NIR-II
(1064[Formula:
text]nm/other
wavelength
beyond
1000[Formula:
can
afford
deeper
tissue
penetration
depth
high
clarity
due
merits
of
suppressed
photon
scattering
and
diminished
autofluorescence.
this
review,
we
have
summarized
excitable/emissive
organic/polymeric
fluorophores
recently
developed.
characteristics
these
such
as
chemical
structures
photophysical
properties
also
been
critically
discussed.
Furthermore,
latest
development
noninvasive
vivo
was
highlighted.
ideal
results
emphasized
importance
enabling
deep
high-resolution
imaging.
Finally,
a
perspective
on
challenges
prospects
We
expected
review
will
be
served
source
inspiration
for
researchers,
stimulating
creation
novel
excitable
fostering
bioimaging
applications.
Langmuir,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 9, 2024
Aggregation-induced
electrochemiluminescence
(AIECL)
combines
the
merits
of
aggregation-induced
emission
(AIE)
and
(ECL),
which
has
become
a
research
hot
spot
in
recent
years.
Therefore,
we
synthesized
novel
AIE
compound
(
