Recent advances for enhanced photodynamic therapy: from new mechanisms to innovative strategies

Chemical Science, Journal Year: 2024, Volume and Issue: 15(31), P. 12234 - 12257

Published: Jan. 1, 2024

Photodynamic therapy (PDT) has been developed as a potential cancer treatment approach owing to its non-invasiveness, spatiotemporal control and limited side effects. Currently, great efforts have made improve the PDT effect in terms of safety efficiency. In this review, we highlight recent advances innovative strategies for enhanced PDT, including (1) development novel radicals, (2) design activatable photosensitizers based on TME light, (3) photocatalytic NADH oxidation damage mitochondrial electron transport chain. Additionally, new mechanisms are also presented an inspiration PSs. Finally, discuss current challenges future prospects clinical practice these strategies. It is hoped that review will provide angle understanding relationship between intratumoural redox environment mechanisms, ideas smart systems.

Language: Английский

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Smart self-transforming nano-systems for overcoming biological barrier and enhancing tumor treatment efficacy

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 85 - 107

Published: Feb. 5, 2025

Language: Английский

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Hierarchically Engineered Self-Adaptive Nanoplatform Guided Intuitive and Precision Interventions for Deep-Seated Glioblastoma

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Glioblastoma multiforme (GBM), particularly the deep-seated tumor where surgical removal is not feasible, poses great challenges for clinical treatments due to complicated biological barriers and risk of damaging healthy brain tissue. Here, we hierarchically engineer a self-adaptive nanoplatform (SAN) that overcomes delivery by dynamically adjusting its structure, surface charge, particle size, targeting moieties precisely distinguish between parenchyma cells. We further devise

Language: Английский

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Glutathione/Cysteine Dual‐Consuming Prodrug Nanoassemblies for Potentiated Gas‐Photodynamic Therapy

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 14, 2025

Abstract Tuning the oxidative stress‐defense system plays a vital role in treatment of breast tumors. In this study, pyropheophorbide‐a (PPa)‐based prodrug nanoassembly is constructed by linking PPa with furoxan, cysteine‐depleting nitric oxide (NO) donor, through disulfide bond. The as‐prepared (NOSP) can assemble distearoyl phosphoethanolamine‐PEG 2000 (DSPE‐PEG ) to form nanoassemblies aqueous media. Following internalization tumor cells, NOSP respond cysteine (Cys) and induce NO release activate endogenous matrix metalloproteinases (MMP‐1, ‐2), leading collagen degradation improved drug delivery. addition, Cys consumption impede biosynthesis glutathione (GSH), while react high levels intracellular GSH within seconds, thus synergizing photodynamic therapy against tumors distant metastasis.

Language: Английский

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Dual‐Responsive Shape‐Transformable Charge‐Reversible Nanoparticles Combined with Chemo‐Photodynamic‐Immunotherapy for the Treatment of Breast Cancer and Lung Metastasis

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(48)

Published: July 1, 2024

Abstract Herein, a dual‐responsive shape‐transforming charge‐reversal integrated nanomedicine system (DHP@BPP) is developed for the co‐delivery of photosensitizer pyro pheophorbide‐α (Ppa), anti‐programmed cell death ligand 1 (PD‐L1) peptide (dPPA), and tumor‐associated macrophages (TAMs)‐regulating drug berberrubine (BBR). Hydrophobic Ppa hydrophilic BBR are linked by matrix metalloproteinase‐2 (MMP‐2) responsive (PMGMRKLVFF) to form BPP. BPP can self‐assemble into spherical nanoparticles with positive charge, which undergo shape transformation nanofibers upon cleavage MMP‐2 at tumor sites. The dPPA conjugated hexa‐histidine polyethylene glycol DHP, then electrostatically adsorbed onto surface DHP@BPP negative charge. DHP not only enhances tumor‐targeting but also induces disassociation charge reversal due protonation histidine site, thereby increasing penetration while maintaining long blood circulation. Most importantly, through combination chemo‐photodynamic‐immunotherapy, it repolarize TAMs from M2‐type M1‐type reducing PD‐L1 expression reshape immunosuppressive microenvironment, synergistically enhancing effect immunogenic death. In conclusion, this study offered simple effective idea treatment cancers reversal, integrating chemo‐photodynamic‐immunotherapy.

Language: Английский

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Dual‐Activatable Nano‐Immunomodulator for NIR‐II Fluorescence Imaging‐Guided Precision Cancer Photodynamic Immunotherapy

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 14, 2024

Abstract Photodynamic immunotherapy which combines photodynamic therapy with has become an important and effective method for the treatment of cancer. However, most cancer immunotherapeutic systems are not able to achieve precise release immunomodulators, resulting in systemic side effects poor patient outcomes. Herein, a dual‐activatable nano‐immunomodulator (DIR NP), both its effect agonist can be activated under specific stimuli, is reported precision immunotherapy. The DIR NP self‐assembled from R848‐conjugated amphiphilic polymer (mPEG‐TK‐R848) hydrophobic oxidized bovine serum albumin (BSA‐SOH)‐conjugatable photosensitizer (DIR). NPs may generate small amount 1 O 2 808 nm laser irradiation, leading cleavage thioketal (TK) moiety R848 DIR. released conjugate tumor‐overexpressed BSA‐SOH, improving efficiency NIR‐II fluorescence signal. Such improvement further enhance cargoes upon irradiation. induces immunogenic cell death (ICD) immune factors maturation dendritic cells inhibiting growth primary distant tumors eliminating lung metastasis. Therefore, this study provides intelligent regulation tumor

Language: Английский

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