Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 158907 - 158907
Published: Dec. 1, 2024
Language: Английский
Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.
Language: Английский
Citations
4
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
Abstract Engineered modifications of nanomaterials inspired by nature hold great promise for disease‐specific imaging and therapies. However, conventional polyethylene glycol modification is limited immune system rejection. The manipulation gold nanorods (Au NRs) modified endogenous proteins (eP@Au) reported as an engineered biomodulator enhanced breast tumor therapy. results show that eP@Au NRs neither activate inflammatory factors in vitro nor elicit rejection responses vivo. Tumor‐specific exhibit a dual‐modal capability trigger mild photothermal effect under near‐infrared light irradiation, enabling highly efficient therapy tumors. Transcriptome sequencing confirmatory experiments reveal the antitumor mainly attributed to repression PI3K‐Akt/MAPK signaling pathways at molecular level. This powerful surprising situ eP‐regulated biomodulation demonstrates advantages convenient fabrication, inert immunogenicity, biocompatibility, providing alternative strategy biomedical
Language: Английский
Citations
1
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 3, 2025
Abstract Immunotherapy holds notable progress in the treatment of cancer. However, clinical therapeutic effect remains a significant challenge due to immune-related side effects, poor immunogenicity, and immunosuppressive microenvironment. Nanoparticles have emerged as revolutionary tool surmount these obstacles amplify potency immunotherapeutic agents. Prussian blue nanoparticles (PBNPs) exhibit multi-dimensional immune function cancer immunotherapy, including acting nanocarrier deliver agents, photothermal agent improve efficacy immunotherapy through therapy, nanozyme regulate tumor microenvironment, an iron donor induce events related ferroptosis tumor-associated macrophages polarization. This review focuses on advances applications PBNPs immunotherapy. First, biomedical functions are introduced. Then, based PBNPs, we systematically reviewed multidimensional application Finally, challenges future developments PBNPs-based highlighted. Graphical abstract
Language: Английский
Citations
0
Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 19
Published: March 10, 2025
Cancer remains a significant global health challenge, driving the search for innovative treatments. Photothermal therapy (PTT) has emerged as promising approach, using photothermal agents to convert near-infrared (NIR) light into heat tumor ablation. Among these agents, nano-molybdenum oxide, particularly non-stoichiometric MoO3-x (0 < x 1), stands out due its unique defect structure, strong NIR absorption, high conversion efficiency (PCE), and pH-responsive degradation. This review summarized recent advancements in oxide PTT, covering classification, synthesis, surface modification, tumor-targeting mechanisms. Subsequently, we explored applications PTT combination therapies, evaluated biocompatibility toxicity, discussed current achievements, challenges, future perspectives cancer treatment.
Language: Английский
Citations
0
ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1737 - 1745
Published: April 3, 2025
Language: Английский
Citations
0
Composites Part B Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 112504 - 112504
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 694, P. 137688 - 137688
Published: April 23, 2025
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 667, P. 124956 - 124956
Published: Nov. 15, 2024
Language: Английский
Citations
1
Biomaterials Advances, Journal Year: 2024, Volume and Issue: 169, P. 214161 - 214161
Published: Dec. 23, 2024
Language: Английский
Citations
1
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12
Published: Sept. 11, 2024
Spinal cord injury (SCI) is a serious neurological condition that currently lacks effective treatments, placing heavy burden on both patients and society. Prussian blue nanoparticles exhibit great potential for treating spinal injuries due to their excellent physicochemical properties biocompatibility. These have strong anti-inflammatory antioxidant capabilities, effectively scavenge free radicals, reduce oxidative stress damage cells. nanotechnology shows broad application in drug delivery, bioimaging, cancer therapy, treatment, biosensors. This article reviewed the applications of injuries, explored challenges solutions associated with its application, discussed future prospects this technology SCI treatment.
Language: Английский
Citations
0