Journal of the American Chemical Society,
Journal Year:
2024,
Volume and Issue:
146(47), P. 32582 - 32594
Published: Nov. 13, 2024
Near-infrared
II
(NIR-II)
phototheranostic
agents
have
become
prominent
for
the
early
diagnosis
and
precise
treatment
of
cancer.
Organic
open-shell
diradicaloids
with
distinct
structure
narrow
band
gap
are
promising
candidates
phototherapeutic
due
to
their
strong
spin-coupling
effect
NIR
light-harvesting
capacity.
However,
achieving
stable
efficient
NIR-II
luminescent
is
crucial
yet
rather
challenging
considering
high
chemical
reactivity
self-absorption.
Herein,
two
highly
diradicaloids,
2PhNVDPP
PhNVDPP,
were
successfully
fabricated
by
employing
an
acceptor
planarization/π-conjugation
extension
donor
rotation
strategy.
After
encapsulation
into
water-dispersible
nanoparticles
(NPs),
NPs
exhibit
luminescence,
PCE
53%,
improved
photo/heat
stability.
In
vivo
experiments
demonstrated
clear
visualization
blood
vessels
tumors,
as
well
successful
imaging-guided
photothermal
ablation
tumors.
This
study
not
only
develops
a
pioneering
diradicaloid
agent
luminescence
but
also
provides
unique
perspective
effectiveness
multimodal
anticancer
therapy.
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Photothermal
therapy
(PTT)
is
a
cutting-edge
technique
that
harnesses
light
energy
and
converts
it
into
heat
for
precise
tumor
ablation.
By
employing
photothermal
agents
to
selectively
generate
target
cancer
cells,
PTT
has
emerged
as
promising
treatment
strategy.
Notably,
therapies
conducted
in
the
second
near-infrared
(NIR-II)
window
exhibit
superior
therapeutic
outcomes,
owing
deeper
tissue
penetration
reduced
scattering.
In
this
study,
we
developed
biomimetic
NIR-II
aggregation-induced
emission
(AIE)
nanoparticles
(2TB-NPs@TM)
high-efficiency
imaging
targeted
phototherapy
of
ovarian
cancer.
The
core
nanoparticle
aggregates
(2TB-NPs)
display
strong
fluorescence
high
conversion
efficiency,
while
outer
cell
membrane
coating
facilitates
active
targeting
recognition
tissues.
This
design
imparts
excellent
biocompatibility
enhances
drug
delivery
leading
potent
synergistic
effects.
Our
findings
open
new
avenues
advancing
targeted,
high-performance
diagnostics
treatment.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 19, 2025
Cell
membrane-coated
nanoparticle-based
delivery
systems
often
struggle
with
inevitable
drug
leakage
during
the
process
and
inefficient
release
at
tumor
site,
resulting
in
unsatisfactory
antitumor
outcomes.
Here,
we
present
an
electrostatically
stabilized
light-activated
membrane
system
(Hybrid
nanoparticles,
[Hm]@NPs)
for
leak-free
delivery,
coupled
precisely
site-specific
controllable
release,
to
elevate
cancer
treatment.
[Hm]@NPs
are
constructed
by
encapsulating
aggregation-induced
emission
(AIE)
photosensitizer
(Phenalen-1-one-quinoline
malonitrile-thiophene
tribenamine,
Phe-Qui-T)
into
a
positively
charged
reactive
oxygen
species
(ROS)-responsive
polymer
(F127-TP-U11)
form
nanoparticle
then
coating
it
negatively
hybrid
containing
red
blood
cell
Panc-1
membrane.
high
stability
effectively
prevent
through
electrostatic
interaction
between
nanoparticle.
Simultaneously,
Phe-Qui-T
light-controlled
ROS
generation
efficiently
destroys
both
ROS-responsive
membrane,
ensuring
precise
sufficient
while
enabling
photodynamic
therapy
(PDT),
thereby
augmenting
efficacy.
show
impressive
inhibition
pancreatic
mouse
models,
highlighting
potential
of
this
membrane-disruption
strategy
advanced
nanodelivery
design.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
31, P. 101488 - 101488
Published: Jan. 13, 2025
Photothermal
therapy
(PTT)
utilizes
photothermal
materials
to
convert
light
energy
into
heat
under
external
irradiation,
effectively
killing
cancer
cells.
Therefore,
the
efficacy
of
PTT
is
largely
determined
by
conversion
efficiency
material.
In
this
study,
we
developed
a
novel
ladder-type
conjugated
polymer,
PPAPA,
via
phenazine
ring
fusion
reaction.
PPAPA
exhibits
high
75.2
%
1064
nm
laser
comparable
benchmark
organic
agent
SWCNT.
Notably,
synthesis
avoids
use
noble
metal
catalysts,
eliminating
potential
biotoxicity
caused
residual
catalysts
and
ensuring
optimal
stability
efficiency.
Furthermore,
demonstrates
efficient
near-infrared
II
(NIR-II)
enabling
deeper
tissue
penetration
reduced
absorption.
This
work
comprehensively
investigates
properties
evaluates
its
in
tumor
PTT,
demonstrating
as
effective
therapeutic
strategy
for
treatment,
offering
new
hope
patients.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 27, 2025
Abstract
The
stacking
mode
in
aggregate
state
results
from
a
delicate
balance
of
supramolecular
interactions,
which
closely
affects
the
optoelectronic
properties
organic
π‐conjugated
systems.
Then,
managing
these
interactions
is
crucial
for
advancing
phototheranostics,
yet
remains
challenging.
A
subtle
strategy
involving
peripheral
phenyl
groups
debuted
herein
to
transform
X‐aggregated
SQ‐H
into
J‐aggregated
SQ‐Ph,
reorienting
intermolecular
dipole
while
rationally
modulating
π–π
interactions.
Co‐assembled
with
liposomes
(DSPE‐PEG2000),
SQ‐Ph
nanoparticles
(NPs)
exhibit
low
toxicity,
superior
biocompatibility,
and
bathochromic
shift
1064
nm
match‐excited
NIR‐II
region,
fluorescence
brightness
(ε
Φ
)
4129
M
−1
cm
photothermal
conversion
efficiency
(PCE)
48.3%.
Preliminary
vivo
experiments
demonstrate
that
NPs
achieve
signal‐to‐background
ratio
(SBR)
up
14.29
imaging
(FLI),
enabling
highly
efficient
therapy
(PTT)
tumors
guided
by
combined
photoacoustic
(PAI).
This
study
not
only
enriches
J‐aggregation
library
but
also
provides
paradigm
optimizing
photosensitizers
at
level.
Inorganic Chemistry Frontiers,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
In
this
work,
novel
zinc(
ii
)
phthalocyanine
nanoparticles
(ZnPcNPs)
have
been
developed
and
verified
to
be
a
promising
PTT/PDT
agent
with
high
photoconversion
efficiency
of
30.01%
under
660
nm
NIR-I
laser
exposure.
Immunotherapy
as
a
transformative
cancer
treatment
modality
frequently
struggles
with
the
immunosuppressive
tumor
microenvironment,
which
hinders
effective
immune
responses.
In
this
report,
we
construct
biomimetic
cell
membrane-cloaked
porous
covalent
organic
framework
(COF)
nanophotosensitizers
(CMSCOFs)
to
synergistically
enhance
photodynamic
therapy
(PDT)
and
stimulate
interferon
genes
(STING)-mediated
immunotherapy.
CMSCOF
is
prepared
from
porphyrin
benzothiadiazole-based
units
cloaked
4T1
membranes
for
homologous
targeting.
The
structure
of
COF
enables
efficient
encapsulation
non-nucleotide
STING
agonist
SR717.
Upon
660
nm
light
irradiation,
CMSCOFs
trigger
both
type
I
II
effects
by
producing
superoxide
(O2•-)
singlet
oxygen
(1O2).
design
improves
stability
mimics
natural
cells
enhanced
blood
circulation,
accumulation,
homologous-targeting
tumors.
Inside
tissues,
unique
leads
immunogenic
death
(ICD)
upon
exposure
irradiation.
Furthermore,
encapsulated
SR717
released
after
cellular
internalization
activate
pathway
elicit
potent
antitumor
response.
This
synergistic
approach
effectively
reverses
enhances
cytotoxic
T
infiltration,
suppresses
primary
metastatic
tumors,
demonstrating
potential
promising
platform
