Construction of a Microenvironment‐Responsive Antibacterial Hydrogel Packed With Immunomodulatory Carbonized Polymer Dots for Periodontitis Treatment From Multiple Perspectives

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Periodontitis is an increasingly prevalent oral inflammatory disease, whose treatment faces potent challenges because of recurrent bacterial infections, excessive reactive oxygen species (ROS) production, as well unrelenting inflammation‐induced alveolar bone resorption during the pathological process. Herein, we present rational design and construction a multifunctional hydrogel platform composed quaternized chitosan/oxidized dextran (QCS/OD) component with high bactericidal activity immunomodulatory carbonized polymer dots from resveratrol (RSV‐CPDs) for periodontitis treatment. Such RSV‐CPDs@QCS/OD (RCQD) hydrogels exhibit characteristics including shape adaptability, self‐healing properties, pH‐responsibility, enabling it to adapt irregularly shaped periodontal tissues, degrade gradually in mildly acidic microenvironment periodontitis, release RSV‐CPDs controlled manner. Significantly, RCQD can effectively suppress proliferation bacteria alleviate oxidative stress, relieve inflammation via activating Nrf2/NF‐κB signaling pathway, ultimately fostering favorable environment regeneration both soft hard tissue. Overall, this study highlights great potential treating by addressing practical needs tissue regeneration.

Language: Английский

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Rationally constructing the theranostics hydrogels for targeted CT imaging and healing of inflammatory bowel disease

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162986 - 162986

Published: April 1, 2025

Language: Английский

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Berberine-Functionalized Bismuth-Doped Carbon Dots in a Pathogen-Responsive Hydrogel System: A Multifaceted Approach to Combating Periodontal Diseases

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Periodontal disease, a global health burden linked to dysbiotic oral polymicrobial communities and disrupted immune-inflammatory responses, is critically mediated byPorphyromonas gingivalis(Pg)─the keystone pathogen that sabotages host immunity, triggers tissue inflammation destruction, disrupts microbiota balance. Effective therapies should combine antimicrobial action, immune modulation, virulence suppression, microbiome restoration. Bismuth ions berberine, which exhibit epithelial barrier-protecting effects, show potential effectiveness in treating periodontal diseases but face practical limitations due poor water solubility bioavailability. To address this, we developed bismuth-doped carbon dots functionalized with structure-modified berberine (BiCD-Ber) as multifunctional nanomedicine. BiCD-Ber eradicated Pg various forms, restored Pg-perturbed responses gingival fibroblasts, preserved barrier integrity. The doped bismuth neutralized factors by blocking the catalytic sites of gingipains. facilitate vivo delivery, was encapsulated disulfide-modified hyaluronic acid hydrogel degrades response metabolites. This system modulated subgingival microbiota, alleviated gingiva, thereby prevented alveolar bone loss. approach concurrently eliminating Pg, modulating inflammatory , suppressing factors, restoring showcases great managing periodontitis effectively.

Language: Английский

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Azithromycin-loaded PLGA Microspheres Coated with Silk Fibroin Ameliorate Inflammation and Promote Periodontal Tissue Regeneration

Regenerative Biomaterials, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 14, 2024

Abstract Periodontitis, a widespread inflammatory disease, is the major cause of tooth loss in adults. While mechanical periodontal therapy benefits disease treatment, adjunctive also necessary. Topically applied anti-inflammatory agents have gained considerable attention periodontitis therapy. Although azithromycin (AZM) possesses excellent properties, its bioavailability limited owing to poor water solubility and absence sustained release mechanisms. Herein, we synthesized biodegradable microspheres (AZM@PLGA-SF) for AZM locally ameliorate inflammation facilitate tissue regeneration. was encapsulated poly (lactic-co-glycolic acid) (PLGA) (AZM@PLGA) using single emulsion-solvent evaporation, followed by surface coating with silk fibroin (SF) via electrostatic adsorption, reducing initial burst AZM. In vivo, local treatment AZM@PLGA-SF significantly reduced restored healthy levels. Mechanically, formulated regulated microenvironment levels pro-inflammatory cytokines (tumor necrosis factor -α, interleukin [IL]-6, interferon-γ, IL-2, IL-17A) gingival crevicular fluid promoted expression (IL-4 IL-10). demonstrated biological safety. Therefore, introduce an substantial potential mitigating encouraging repair regeneration tissues.

Language: Английский

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Two birds with one stone: Natural polyphenols boosted periodontitis treatment of chlorhexidine via reducing toxicity and regulating microenvironments

Materials Horizons, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Chlorhexidine (CHX) is considered the gold standard for controlling periodontal plaque and has been extensively used as a topical agent in treating periodontitis. Nevertheless, practical clinical application of CHX still constrained by inherent limitations its properties, including toxicity, inadequate biofilm scavenging capacity, single biological effect. In this study, polyphenolic epigallocatechin gallate (EGCG) employed to integrate with form an EGCG-CHX nanoplatform

Language: Английский

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Nanomaterial‐Mediated Reprogramming of Macrophages to Inhibit Refractory Muscle Fibrosis

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 16, 2024

Abstract Orofacial muscles are particularly prone to refractory fibrosis after injury, leading a negative effect on the patient's quality of life and limited therapeutic options. Gaining insights into innate inflammatory response‐fibrogenesis homeostasis can aid in development new strategies for muscle fibrosis. In this study, crucial role macrophages is identified regulation orofacial fibrogenesis injury. Hypothesizing that orchestrating macrophage polarization functions will be beneficial treatment, nanomaterials engineered with polyethylenimine functionalization regulate phenotype by capturing negatively charged cell‐free nucleic acids (cfNAs). This cationic nanomaterial reduces macrophage‐related inflammation vitr demonstrates excellent efficacy preventing vivo. Single‐cell RNA sequencing reveals proportion profibrotic Gal3 + through cfNA‐mediated TLR7/9‐NF‐κB signaling pathway, resulting shift fibro‐adipogenic progenitors (FAPs) from matrix‐producing Fabp4 subcluster matrix‐degrading Igf1 subcluster. The study highlights strategy target suggests exploited treating

Language: Английский

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Hydrogels in Alveolar Bone Regeneration

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Alveolar bone defects caused by oral trauma, alveolar fenestration, periodontal disease, and congenital malformations can severely affect function facial aesthetics. Despite the successful clinical applications of grafts or substitutes, optimal regeneration continues to be challenging due complex environment its unique physiological functions. Hydrogels that serve as promising candidates for tissue are under development meet specific needs increased capacity improved operational efficiency in repair. In this review, we emphasize considerations hydrogel design summarize latest hydrogels prevalent diseases related defects. The future perspectives challenges application field also discussed. Deepening our understanding these biomaterials will facilitate advent novel inventions improve outcome regeneration.

Language: Английский

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