APL Bioengineering, Journal Year: 2021, Volume and Issue: 5(2)
Published: April 5, 2021
One of the key challenges in engineering three-dimensional tissue constructs is development a mature microvascular network capable supplying sufficient oxygen and nutrients to tissue. Recent angiogenic therapeutic strategies have focused on vascularization constructed tissue, its integration
Language: Английский
Progress in Additive Manufacturing, Journal Year: 2022, Volume and Issue: 8(5), P. 1007 - 1041
Published: Dec. 27, 2022
Language: Английский
Citations
26
Nanotheranostics, Journal Year: 2024, Volume and Issue: 8(2), P. 127 - 149
Published: Jan. 1, 2024
Cardiovascular disease is one of the chief factors that cause ischemic stroke, myocardial infarction, and venous thromboembolism.The elements speed up thrombosis include nutritional consumption, physical activity, oxidative stress.Even though precise etiology pathophysiology remain difficult topics primarily rely on traditional medicine.The diagnosis management are being developed using discrete non-invasive non-surgical approaches.One emerging promising approach ultrasound photoacoustic imaging.The advancement nanomedicines offers concentrated therapy diagnosis, imparting efficacy fewer side effects which more significant than conventional medicine.This study addresses potential as theranostic agents for treatment thrombosis.In this article, we describe lead to its consequences, well summarize findings studies thrombus formation in preclinical clinical models also provide insights nanoparticles imaging therapy.
Language: Английский
Citations
6
Biomedical Technology, Journal Year: 2024, Volume and Issue: 7, P. 1 - 14
Published: June 5, 2024
Cardiovascular disease (CVD) remains a leading cause of mortality worldwide, claiming countless lives and posing formidable health challenge. Extensive efforts have been dedicated to combating this disease, including the development innovative biomaterials for blood vessel stents, drug delivery imaging diagnosis. These advancements substantially addressed issues such as patient rejection contamination. In review, we begin by outlining prevalence various forms CVD. Subsequently, delve into advanced biomaterials—including synthetic biomaterials, natural hybrid biomaterials—and medical instruments used in treatment or alleviation CVD, discussing their advantages limitations. Finally, offer insights future prospects strategies refining these technologies moving forward.
Language: Английский
Citations
6
Nano Convergence, Journal Year: 2024, Volume and Issue: 11(1)
Published: March 2, 2024
Abstract Tissue engineering and regenerative medicine have made great progress in recent decades, as the fields of bioengineering, materials science, stem cell biology converged, allowing tissue engineers to replicate structure function various levels vascular tree. Nonetheless, lack a fully functional system efficiently supply oxygen nutrients has hindered clinical application bioengineered tissues for transplantation. To investigate biology, drug transport, disease progression, vascularization engineered medicine, we analyzed different approaches designing microvascular networks create models. This review discusses advances field engineering, explores potential future challenges, offers methodological recommendations.
Language: Английский
Citations
5
Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15
Published: June 3, 2024
Methods: Herein, we obtained and characterized deltaN p63- adenosine triphosphate-binding cassette subfamily G member 2-expressing limbal stem cells (LSCs). Chitosan carboxymethyl chitosan (CTH) were cross-linked to be an in situ thermosensitive hydrogel (ACH), which was printed through four-dimensional (4D) printing obtain a porous carrier with uniform pore diameter (4D-CTH). Rabbits injected alloxan induce diabetes mellitus (DM). Following this, the LSC-carrying spread on surface of cornea diabetic rabbits cure corneal epithelium injury. Results: Compared control group (LSCs only), rapid wound healing observed treated 4D-CTH. Furthermore, test also showed better nerve repair ability. The results indicated potential 4D-CTH curing Conclusion: holds as useful tool for studying regenerative processes occurring during treatment various pathologies use cell-based technologies.
Language: Английский
Citations
5
Macromolecular Materials and Engineering, Journal Year: 2020, Volume and Issue: 306(2)
Published: Dec. 9, 2020
Abstract Microspheres applied in medical applications experience explosive development recent years, such as drug release, cell culture, and bone tissue engineering, etc. However, there are still some bottlenecks both economy technology lay that cannot be ignored. For instance, microsphere has not been used culture widely because of its uneconomical cost; the core drug‐loaded microsphere, targeted is mature enough. Besides, common fabrication methods: microfluidic or emulsion difficult to guarantee high biocompatibility due utilization photoinitiator, crosslinking agent, surfactant, other substances. Therefore, gas‐shearing proposed solve these above shortcomings successfully. This paper focuses more on heteromorphic microspheres rather than single which begins with a minute introduction preparation microfluidic, coaxial electrospray, emulsion, technology. Then applications: hemostasis discussed detail. The disadvantages methods for at present also stated. At end, perspectives put forward.
Language: Английский
Citations
35
Biofabrication, Journal Year: 2021, Volume and Issue: 14(1), P. 015003 - 015003
Published: Sept. 30, 2021
In the microvasculature, blood flow-derived forces are key regulators of vascular structure and function. Consequently, development hydrogel-based microvessel-on-chip systems that strive to mimic thein vivocellular organization mechanical environment has received great attention in recent years. However, despite intensive efforts, current suffer from several limitations, most notably failure produce physiologically relevant wall strain levels. this study, a novel based on templating technique using luminal flow actuation generate levels shear stress circumferential stretch is presented. Normal induced by pressure compress surrounding soft collagen hydrogel, dilate channel, create large strain. The fluid gradient system drives forward generates realistic pulsatile stresses. Rigorous characterization reveals crucial role played poroelastic behavior hydrogel determining magnitudes experimental measurements combined with an analytical model both lumen porous provide exceptionally versatile user manual for application-based choice parameters microvessels-on-chip. This unique strategy adds dimension capabilities provides more general framework improving hydrogel-basedin vitroengineered platforms.
Language: Английский
Citations
28
Nano Biomedicine and Engineering, Journal Year: 2024, Volume and Issue: 16(3), P. 357 - 369
Published: Aug. 12, 2024
Language: Английский
Citations
4
Small Methods, Journal Year: 2021, Volume and Issue: 5(10)
Published: Aug. 16, 2021
Abstract Although there are various pre‐existing technologies for engineering vasculatures, multiscale modeling of the architecture human vasculature at a capillary scale remains challenge. In this study, novel technology is developed production functional, microvasculature comprising endothelialized channels and tissue‐specific networks. Perfusable, bioprinted, after which angiogenic sprouts grown into user‐designed The induction branched liver‐lobule‐like networks confirm that can produce types microvasculatures. Further, capillaries deemed to be functional when evaluated in vitro. An ex vivo assay demonstrates induce neovessel ingrowth, integrate with host vessels, facilitate blood flow. Remarkably, flows through implanted network without any change its morphology. Finally, applied vascularized liver tissue; it significantly improves hepatic function. It believed new will create possibilities development highly tissues/organs on clinically relevant scale.
Language: Английский
Citations
24
Microfluidics and Nanofluidics, Journal Year: 2025, Volume and Issue: 29(3)
Published: Feb. 5, 2025
Language: Английский
Citations
0