Fabrication of polymeric microspheres for biomedical applications

Materials Horizons, Journal Year: 2024, Volume and Issue: 11(12), P. 2820 - 2855

Published: Jan. 1, 2024

A systematic summary of fabrication technologies, a variety structures and biomedical applications polymeric microspheres.

Language: Английский

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Core-shell microparticles: From rational engineering to diverse applications

Advances in Colloid and Interface Science, Journal Year: 2021, Volume and Issue: 299, P. 102568 - 102568

Published: Nov. 24, 2021

Language: Английский

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Application advance of electrosprayed micro/nanoparticles based on natural or synthetic polymers for drug delivery system

Materials & Design, Journal Year: 2022, Volume and Issue: 220, P. 110850 - 110850

Published: June 15, 2022

Micro/nanoparticles-based drug delivery system has emerged significantly and influenced the pharma industry up to considerable extent. At same time, development of production methods that are cost effective, scalable reproducible becomes crucial ensure clinical translation any development. The application electrospray (ES) technology in micro-nano not only above advantages, but also can quickly obtain uniform stable micro/nanoparticles as carriers through its own characteristics. Natural or synthetic polymers often used raw materials for these micro/nanoparticles. prepared by change solubility bioavailability drugs reduce toxicity caused mass accumulation after sudden release. And reaching target site, they're easy degrade will accumulate body. In this review, taken together, we briefly describe principle advantages ES, well common preparation method. types electrosprayed their systems different routes diseases were discussed. prospects made future field medicine.

Language: Английский

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Injectable Amphipathic Artesunate Prodrug‐Hydrogel Microsphere as Gene/Drug Nano‐Microplex for Rheumatoid Arthritis Therapy

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(44)

Published: Aug. 24, 2022

Abstract Artemisinin and its derivatives (artemisinins) are first‐line chemotherapeutic agents of lethal malaria, which also showed tremendous value in many other diseases including chronic inflammation. Unfortunately, almost all artemisinins rapid‐acting medicines with an extremely short half‐life vivo, significantly limits their clinical application for these new adaptation diseases. In this study, a locally injectable long‐acting gene/artemisinin co‐delivery nano‐microplex consisting biodegradable hyaluronic acid (HA) microsphere releasable nano‐lipoplex is developed first, to obtain improved efficacy rheumatoid arthritis (RA). Briefly, cationic multicomponent drug‐embedded liposome pharmacological activity first reported based on two novel artemisinin (dAPC dACC), possess mimic phospholipids lipids, respectively. A artemisinin‐embedded lipoplex as medicative gene carrier here. An situ TNF‐α siRNA/artemisinin (MTAsi@MG) further prepared by immobilization siRNA/lipoplex porous microfluidic HA microspheres. Using intra‐articular injection, the sustaining therapy RA long‐term treatment realized. Undoubtedly, dAPC/dACC microspheres would be one most potent gene/drug systems therapy.

Language: Английский

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A comprehensive review of oral chitosan drug delivery systems: Applications for oral insulin delivery

Nanotechnology Reviews, Journal Year: 2024, Volume and Issue: 13(1)

Published: Jan. 1, 2024

Abstract Pharmaceutical scientists have long struggled to develop reliable and efficient systems of administering insulin orally due multiple barriers, including stomach acidity, enzymatic degradation, mucus barriers. However, various strategies were developed avoid degradation in the gastrointestinal tract (GIT) promote membrane permeability biological activity. Among these strategies, chitosan polymer-based carriers are widely researched their ability protect alimentary canal deliver it effectively through intestinal mucosa, improving its bioavailability. To improve properties, chemical physical modifications been developed, recently, nanoparticles, microparticles, beads exhibited potential for oral delivery (OID). This review facilitates an outline types diabetes mellitus, biosynthesis, barriers against insulin. Moreover, limitations subcutaneous alternative routes administration also discussed. As ideal most convenient route, challenges safe GIT elevate bioavailability highlighted. In addition, this focuses on recent advancements based OID future applications.

Language: Английский

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One‐Step Fabrication of Highly Customizable Porous Core–Shell Microspheres for the Construction of a 3D Physiologically Relevant Perivascular‐Endosteal Multi‐Microenvironment Model of Breast Cancer Bone Metastasis

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Abstract The 3D model of the perivascular‐endosteal multi‐microenvironment (PVM‐EM) is crucial for studying early stage breast cancer (BrCa) bone metastasis. However, existing models struggle to accurately represent composition and spatial intricacies multi‐microenvironments, limiting their ability support cellular functional expression within these systems. Here, nested aqueous two‐phase system emulsion as a template develop novel type core‐shell microsphere establishing PVM‐EM utilized. This enables precise control over chemical composition, macroporous structure, cell localization. By adjusting parameters in each microenvironment, it successfully reconstructed PVM with compartmentalized distribution core EM shell one step. outcomes indicate that porous architecture localization significantly enhance activity function microenvironment. Importantly, this effectively encapsulates key biological processes associated colonization BrCa metastasis, including elevated cytokine expression, extensive angiogenesis PVM, significant inhibition alkaline phosphatase EM. method paves way efficient physiologically relevant models, facilitating future preclinical research drug screening

Language: Английский

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Sodium alginate/low methoxyl pectin composite hydrogel beads prepared via gas-shearing technology for enhancing the colon-targeted delivery of probiotics and modulating gut microbiota

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140375 - 140375

Published: Jan. 1, 2025

Language: Английский

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Microspheres: Preparation Methods, Advances, Applications, and Challenges in Drug Delivery

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Language: Английский

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Injectable nanofiber microspheres modified with metal phenolic networks for effective osteoarthritis treatment

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 157, P. 593 - 608

Published: Nov. 24, 2022

Language: Английский

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Microspheres in bone regeneration: Fabrication, properties and applications

Materials Today Advances, Journal Year: 2022, Volume and Issue: 16, P. 100315 - 100315

Published: Nov. 2, 2022

In the last few decades, microspheres and microsphere-based scaffolds have demonstrated great potential in translational medicine. Various materials, including natural polymers, synthetic bioactive ceramics, their composites, been fabricated into for bone-defect repair. this review, we summarize specific steps research progress of various fabrication methods identify main limitations existing techniques. The appropriate materials surface-modification strategies that can increase biological properties are also described. Finally, discuss key application microsphere-functionalized bone tissue engineering. We expect review will enable more future investigations focus on field microsphere engineering, thus advance development technology facilitate regeneration.

Language: Английский

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