Bioinspired double network hydrogels: from covalent double network hydrogelsviahybrid double network hydrogels to physical double network hydrogels

Materials Horizons, Journal Year: 2020, Volume and Issue: 8(4), P. 1173 - 1188

Published: Dec. 10, 2020

This minireview discusses the advantages and challenges in constructing bioinspired double-network hydrogels mimicking structure and/or properties of biological tissue.

Language: Английский

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Enhancing Biopolymer Hydrogel Functionality through Interpenetrating Networks

Trends in biotechnology, Journal Year: 2020, Volume and Issue: 39(5), P. 519 - 538

Published: Sept. 16, 2020

Language: Английский

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A Logic‐Based Diagnostic and Therapeutic Hydrogel with Multistimuli Responsiveness to Orchestrate Diabetic Bone Regeneration

Advanced Materials, Journal Year: 2021, Volume and Issue: 34(11)

Published: Dec. 18, 2021

The regeneration of diabetic bone defects remains challenging as the innate healing process is impaired by glucose fluctuation, reactive oxygen species (ROS), and overexpression proteinases (such matrix metalloproteinases, MMPs). A "diagnostic" therapeutic dual-logic-based hydrogel for therefore developed through design a double-network consisting phenylboronic-acid-crosslinked poly(vinyl alcohol) gelatin colloids. It exhibits logic to interpret pathological cues (glucose ROS, MMPs) determines when release drug in microenvironment program different cargo match immune-osteo cascade better tissue regeneration. also shown be mechanically adaptable local complexity at defect. Furthermore, underlying mechanism elucidated, whereby logic-based enables regulation macrophage polarization remodeling mitochondria-related antioxidative system, resulting enhanced osteogenesis defects. This study provides critical insight into biological tissue-engineering strategies

Language: Английский

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Hydrogel‐Based Growth Factor Delivery Platforms: Strategies and Recent Advances

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(5)

Published: April 3, 2023

Growth factors play a crucial role in regulating broad variety of biological processes and are regarded as powerful therapeutic agents tissue engineering regenerative medicine the past decades. However, their application is limited by short half-lives potential side effects physiological environments. Hydrogels identified having promising to prolong growth mitigate adverse restricting them within matrix reduce rapid proteolysis, burst release, unwanted diffusion. This review discusses recent progress development factor-containing hydrogels for various biomedical applications, including wound healing, brain repair, cartilage bone regeneration, spinal cord injury repair. In addition, introduces strategies optimizing factor release affinity-based delivery, carrier-assisted stimuli-responsive spatial structure-based cellular system-based delivery. Finally, presents current limitations future research directions factor-delivering hydrogels.

Language: Английский

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Progress in Gelatin as Biomaterial for Tissue Engineering

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(6), P. 1177 - 1177

Published: May 31, 2022

Tissue engineering has become a medical alternative in this society with an ever-increasing lifespan. Advances the areas of technology and biomaterials have facilitated use engineered constructs for issues. This review discusses on-going concerns latest developments widely employed biomaterial field tissue engineering: gelatin. Emerging techniques including 3D bioprinting gelatin functionalization demonstrated better mimicking native by reinforcing gelatin-based systems, among others. breakthrough facilitates, on one hand, manufacturing process when it comes to practicality cost-effectiveness, which plays key role transition towards clinical application. On other can be concluded that could considered as promising future trends, focus might detection diagnosis diseases rather than treatment.

Language: Английский

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An All-in-One Tannic Acid-Containing Hydrogel Adhesive with High Toughness, Notch Insensitivity, Self-Healability, Tailorable Topography, and Strong, Instant, and On-Demand Underwater Adhesion

ACS Applied Materials & Interfaces, Journal Year: 2021, Volume and Issue: 13(8), P. 9748 - 9761

Published: Feb. 16, 2021

Hydrogels that are mechanically tough and capable of strong underwater adhesion can lead to a paradigm shift in the design adhesives for variety biomedical applications. We hereby innovatively develop facile but efficient strategy prepare hydrogel with instant adhesion, on-demand detachment, high toughness, notch-insensitivity, self-healability, low swelling index, tailorable surface topography. Specifically, polymerization lyophilization conjugation fabrication method was proposed introduce tannic acid (TA) into covalent network consisting polyethylene glycol diacrylate (PEGDA) substantially molecular weight. The presence TA facilitated wet various substrates by forming collectively noncovalent bonds offering hydrophobicity allow water repellence also provided reversible cross-link within binary improve mechanical performance gels. long-chain PEGDA enhanced efficacy stability contributed gel mechanics allowing chain diffusion entanglement formation. Moreover, PEGDA/TA hydrogels were demonstrated be biocompatible accelerating wound healing skin animal model as compared commercial tissue applied treatment both epidermal intracorporeal wounds. Our study provides new, critical insight principle all-in-one outstanding adhesive properties potentially enhance healing.

Language: Английский

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Exosomes from adipose-derived stem cells regulate M1/M2 macrophage phenotypic polarization to promote bone healing via miR-451a/MIF

Stem Cell Research & Therapy, Journal Year: 2022, Volume and Issue: 13(1)

Published: April 8, 2022

Abstract Objectives Bone defects caused by diseases and trauma are usually accompanied inflammation, the implantation of biomaterials as a common repair method has also been found to cause inflammatory reactions, which affect bone metabolism new formation. This study investigated whether exosomes from adipose-derived stem cells (ADSC-Exos) plays an immunomodulatory role in traumatic elucidated underlying mechanisms. Methods ADSC-Exos were loaded biomaterial named gelatine nanoparticles (GNPs), physical chemical properties analysed zeta potential, surface topography rheology. A rat model skull defect was used for our vivo studies, micro-CT histological staining analyse changes area. RT-qPCR western blotting performed verify that could regulate M1/M2 macrophage polarization. MicroRNA (miRNA) array analysis conducted determine miRNA expression profiles ADSC-Exos. After macrophages treated with miR-451a mimic, inhibitor ISO-1, relative genes proteins measured blotting. Results In vivo, showed exosome-loaded GNPs (GNP-Exos) hydrogel, good biocompatibility strong mechanical adaptability, exhibited effect mainly regulating immunity promoting tissue healing. Immunofluorescence further indicated reduced M1 marker (iNOS) increased M2 (CD206) expression. Moreover, vitro inhibited upregulated MiR-451a enriched targeted migration inhibitory factor (MIF). Macrophages mimic lower markers. contrast, treatment markers downregulated markers, while ISO-1 (a MIF inhibitor) Conclusion GNP-Exos can effectively immune promote healing partly through regulation miR-451a, may provide therapeutic direction repair.

Language: Английский

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Tough adhesion enhancing strategies for injectable hydrogel adhesives in biomedical applications

Advances in Colloid and Interface Science, Journal Year: 2023, Volume and Issue: 319, P. 102982 - 102982

Published: Aug. 13, 2023

Language: Английский

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An Injectable silk-based hydrogel as a novel biomineralization seedbed for critical-sized bone defect regeneration

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 274 - 290

Published: Feb. 8, 2024

The healing process of critical-sized bone defects urges for a suitable biomineralization environment. However, the unsatisfying repair outcome usually results from disturbed intricate milieu and lack in situ mineralization resources. In this work, we have developed composite hydrogel that mimics natural processes serves as seedbed regeneration. oxidized silk fibroin fibrin are incorporated rigid geogrids, amorphous calcium phosphate (ACP) platelet-rich plasma serve fertilizers loam, respectively. Encouragingly, demonstrates excellent mechanical properties stable scaffold promotes vascularized regeneration vivo. Additionally, succinate-like function via PI3K-Akt signaling pathway subsequently orchestrates mitochondrial uptake, further converting exogenous ACP into endogenous ACP. realizes succession resources evolution biotemplate to collagen. Therefore, our work has established novel silk-based functions an in-situ seedbed, providing new insight defect

Language: Английский

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The application of injectable platelet-rich fibrin in regenerative dentistry: A systematic scoping review of In vitro and In vivo studies

Japanese Dental Science Review, Journal Year: 2022, Volume and Issue: 58, P. 89 - 123

Published: March 29, 2022

Ongoing research in the dental field has begun to focus on use of injectable platelet-rich fibrin (I-PRF) as a regenerative tool with potential prompt tissue regeneration. In this regard, systematic scoping review aimed collect, map, and appraise vitro vivo studies regarding role I-PRF or soft hard regeneration relation oral maxillofacial structures. A electronic search Medline, Scopus, Web Science, Embase databases was performed from 2000 December 2021 using combination keywords. All studies, written English concerning dentistry were considered. total, 18 5 animal 6 case reports, 31 clinical have evaluated effect The investigated verified anti-inflammatory, anti-microbial efficacy positive effects application for wound, periodontal, bone, cartilage, pulp regeneration, well acceleration tooth movement during orthodontic treatment. Current literature approves feasibility promising adjunct procedures.

Language: Английский

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