Journal of Polymer Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
ABSTRACT
Burn
wounds
care
and
healing
are
very
difficult
in
clinic.
Herein,
a
multifunctional
waterproof
hydrogel
was
fabricated
with
photothermal
antimicrobial
NO
anti‐inflammatory
properties.
In
the
as‐prepared
hydrogel,
polyethyleneimine
(PEI)
thioctic
acid
(TA)
were
cross‐linked
by
electrostatic
interactions
hydrogen
bonding
while
aggregation
of
TA
could
be
favor
to
formation
hydrophobic
caves.
Benefit
from
caves,
CuS
BNN6
(N,
N′‐dibutyl‐N,
N′‐dinitroso‐1,4‐phenylenediamine)
incorporated
PEI/TA‐based
air
permeability
also
increased.
Interestingly,
mild
increased
temperature
conversion
not
only
endowed
ability
but
promoted
release
BNN6.
The
PEI/TA/CuS/BNN6
good
biocompatibility,
self‐healing
water
resistance
suitable
for
promoting
burn
healing.
It
provides
new
platform
designing
novel
wound
dressing
wounds.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: July 1, 2024
The
applications
of
hydrogels
have
expanded
significantly
due
to
their
versatile,
highly
tunable
properties
and
breakthroughs
in
biomaterial
technologies.
In
this
review,
we
cover
the
major
achievements
potential
therapeutic
applications,
focusing
primarily
on
two
areas:
emerging
cell-based
therapies
promising
non-cell
modalities.
Within
context
cell
therapy,
discuss
capacity
overcome
existing
translational
challenges
faced
by
mainstream
therapy
paradigms,
provide
a
detailed
discussion
advantages
principal
design
considerations
for
boosting
efficacy
as
well
list
specific
examples
different
disease
scenarios.
We
then
explore
drug
delivery,
physical
intervention
therapies,
other
areas
(e.g.,
bioadhesives,
artificial
tissues,
biosensors),
emphasizing
utility
beyond
mere
delivery
vehicles.
Additionally,
complement
our
latest
progress
clinical
application
outline
future
research
directions,
particularly
terms
integration
with
advanced
biomanufacturing
This
review
aims
present
comprehensive
view
critical
insights
into
selection
both
tailored
meet
requirements
diverse
diseases
situations.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(26)
Published: Feb. 25, 2024
Abstract
Bacterial
infection
at
wound
sites
can
easily
induce
robust
inflammation.
M1
macrophages
cause
cascade
inflammatory
reactions
to
mediate
a
vicious
inflammation
cycle.
Meanwhile,
the
hypoxia
situation
further
aggravates
destruction
and
contraction
of
blood
vessels
in
microenvironment,
therefore,
hindering
infected
healing
process.
Here,
thermosensitive
hydrogel
is
reported
solve
above
challenges
by
eliminating
bacteria
based
on
photothermal
effect,
regulating
immune
providing
oxygen
(O
2
).
In
vitro
vivo
experiments
confirmed
that
has
great
O
‐producing
properties.
Based
excellent
properties
AIEgens,
good
bactericidal
effect
against
S.
aureus
(100%)
E.
coli
(98.85%).
The
RNA‐sequencing
revealed
Cur@AIE@MnO
/gel
interfere
with
metabolic
process
genetic
material
repair
impact
proliferation
biofilm
dispersal,
thus
achieving
anti‐bacterial
efficacy.
Moreover,
also
up‐regulate
anti‐inflammatory
genes,
down‐regulate
pro‐inflammatory
genes
macrophages,
facilitate
promotion
macrophage
polarization
from
M2
relieve
therapeutic
show
this
accelerated
wound‐healing
Therefore,
work
may
open
new
avenues
for
development
novel
dressings
bacterial‐infected
wounds.
Small,
Journal Year:
2024,
Volume and Issue:
20(34)
Published: April 9, 2024
Abstract
Bacterial
infections
and
inflammation
progression
yield
huge
trouble
for
the
management
of
serious
skin
wounds
burns.
However,
some
hydrogel
dressing
exhibit
poor
wound‐healing
capabilities.
Additionally,
little
information
is
given
on
molecular
theory
gelation
mechanisms
drug
release
performance
from
drug‐polymer
network
in
water
environment.
Herein,
cationic
guar
gum
(CG)
first
mixed
with
dipotassium
glycyrrhizinate
(DG),
then
crosslinked
Cu
2+
to
strengthen
mechanical
strength
followed
by
encapsulating
mussel
adhesive
protein
(MAP)
as
composite
dressings.
Intriguingly,
CG‐Cu
0.5
‐DG
10
possessed
proper
rheological
properties
predominantly
driven
strong
CG‐H
2
O‐Cu
‐CG
hydrogen
bonding
interaction.
Weak
DG‐CG
only
controlled
DG
initial
4
h,
while
main
force
regulating
sustained
within
48
h.
The
incorporation
MAP
further
loosened
tight
crosslinking
10.
screened
/MAP
excellent
self‐healing,
injectability,
antibacterial,
anti‐inflammatory,
cell
proliferation‐promotion
activities
high
biocompatibility.
Therefore,
expedited
wound
closure
S.
aureus
‐infected
full‐thickness
model
lowered
necrosis
unburned
interspaces
a
rat
burn
model.
results
highlight
promising
translational
potential
‐inspired
hydrogels
burns
infected
wounds.
Arabian Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
17(10), P. 105968 - 105968
Published: Aug. 17, 2024
Hydrogels
are
three-dimensional
structures
that
serve
as
substitutes
for
the
extracellular
matrix
(ECM)
and
possess
outstanding
physicochemical
biochemical
characteristics.
They
gaining
importance
in
regenerative
medicine
because
of
their
similarity
to
natural
terms
moisture
content
wound
tissue
healing
permeability.
Tissue
engineering
advancements
have
resulted
development
flexible
hydrogels
mimic
dynamic
characteristics
ECM.
Several
approaches
been
applied
produce
from
biopolymers
with
enhanced
functional
structural
different
applications
(TERM).
This
review
provides
a
comprehensive
overview
hydrogel
healing,
engineering,
drug
delivery
systems.
We
outline
types
based
on
physical
chemical
crosslinking,
fundamental
properties,
TERM.
article
provided
recent
literature
within
five
years.
Recent
developments
biopolymer-based
state-of-the-art
discussed,
emphasizing
significant
challenges
future
perspectives.
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 8, 2025
Janus
hydrogels
have
promising
applications
in
tendon
healing
and
anti-peritendinous
adhesions.
However,
their
complicated
preparation
methods,
weak
mechanical
properties,
unstable
adhesion
interfaces
severely
limited
application
suture-free
high-quality
healing.
In
this
work,
by
controlling
the
interfacial
distribution
of
free
-COOH
groups
cationic-π
structures
on
both
sides
hydrogels,
a
series
PZBA-EGCG-ALC
with
varying
degrees
asymmetric
properties
are
successfully
prepared
using
simple
efficient
one-step
synthesis
method.
The
tensile
strength
elongation
at
break
hydrogel
as
high
0.51
±
0.04
MPa
922.89
28.59%.
addition,
can
achieve
difference
(nearly
20-fold)
while
maintaining
strong
bottom
(up
to
524.8
33.1
J
m-2).
spatial
dimension,
its
excellent
compliance
one-sided
behavior
provide
effective
support
physical
barriers
for
injured
Achilles
tendons.
More
importantly,
also
minimize
early
inflammation
generation
time
dimension
via
ROS-responsive
PZBA-EGCG
prodrug
macromolecules.
This
study
provided
more
convenient
strategy
constructing
promote
European journal of medical research,
Journal Year:
2023,
Volume and Issue:
28(1)
Published: Nov. 24, 2023
Abstract
This
paper
gives
a
detailed
analysis
of
nanotechnology's
rising
involvement
in
numerous
surgical
fields.
We
investigate
the
use
nanotechnology
orthopedic
surgery,
neurosurgery,
plastic
oncology,
heart
vascular
ophthalmic
thoracic
and
minimally
invasive
surgery.
The
details
how
helps
with
arthroplasty,
chondrogenesis,
tissue
regeneration,
wound
healing,
more.
It
also
discusses
employment
nanomaterials
implant
surfaces,
bone
grafting,
breast
implants,
among
other
things.
article
explores
various
uses,
including
stem
cell-incorporated
nano
scaffolds,
nano-surgery,
hemostasis,
nerve
nanorobots,
diagnostic
applications.
ethical
safety
implications
using
surgery
are
addressed.
future
possibilities
investigated,
pointing
to
possible
route
for
improved
patient
outcomes.
essay
finishes
comment
on
transformational
influence
applications
its
promise
breakthroughs.
Graphical
Asian Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
19(3), P. 100911 - 100911
Published: April 14, 2024
Precision
therapy
has
become
the
preferred
choice
attributed
to
optimal
drug
concentration
in
target
sites,
increased
therapeutic
efficacy,
and
reduced
adverse
effects.
Over
past
few
years,
sprayable
or
injectable
thermosensitive
hydrogels
have
exhibited
high
potential.
These
can
be
applied
as
cell-growing
scaffolds
drug-releasing
reservoirs
by
simply
mixing
a
free-flowing
sol
phase
at
room
temperature.
Inspired
their
unique
properties,
been
widely
delivery
treatment
platforms
for
precision
medicine.
In
this
review,
state-of-the-art
developments
are
investigated,
which
covers
from
thermo-gelling
mechanisms
main
components
biomedical
applications,
including
wound
healing,
anti-tumor
activity,
osteogenesis,
periodontal,
sinonasal
ophthalmic
diseases.
The
most
promising
applications
trends
of
also
discussed
light
features.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 9, 2024
Abstract
Bacteria
share
a
longstanding
and
complex
relationship
with
humans,
playing
role
in
protecting
gut
health
sustaining
the
ecosystem
to
cause
infectious
diseases
antibiotic
resistance.
Luminogenic
materials
that
aggregation‐induced
emission
(AIE)
characteristics
have
emerged
as
versatile
toolbox
for
bacterial
studies
through
fluorescence
visualization.
Numerous
research
efforts
highlight
superiority
of
AIE
this
field.
Recent
advances
are
categorized
into
four
areas:
understanding
interactions,
antibacterial
strategies,
diverse
applications,
synergistic
applications
bacteria.
Initial
focuses
on
visualizing
unseen
bacteria
progresses
developing
strategies
involving
electrostatic
amphiphilic
luminogens
(AIEgens),
various
enhance
affinity.
progress
includes
using
photodynamic
photothermal
therapies,
toxicity
studies,
combined
therapies.
Diverse
from
environmental
disinfection
disease
treatment,
utilizing
coatings,
sensors,
wound
healing
materials,
etc.,
also
provided.
Finally,
combining
achieve
enhanced
outcomes
explored.
This
review
summarizes
developmental
trend
is
expected
provide
future
directions
advancing
methodologies.
BMEMat,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 24, 2024
Abstract
With
high
biocompatibility
and
degradability,
polysaccharide‐based
hydrogels
are
favorable
healthcare
materials.
However,
in
many
biomedical
applications,
these
materials
inconvenient
to
handle
with
fixed
morphology,
unable
closely
match
the
wounds,
easy
detach
due
insufficient
adhesion.
Inspired
by
superior
wet
adhesive
properties
of
marine
mussels,
researchers
have
used
mussel‐inspired
chemistry
create
mussel‐mimetic
injectable
that
simple
operate,
controllable
shape,
highly
adhesive,
significantly
extended
their
applications
such
as
tissue
adhesives,
delivery
vehicles,
engineering
scaffolds,
wearable
sensors.
there
few
comprehensive
reviews
on
both
adhesion
injectability,
critical
analyses
hydrogels'
preparation
methods
applications.
This
review
fills
this
gap
systematically
summarizes
strategies
for
novel
hydrogels,
including
modifying
polysaccharides
catechol‐
or
pyrogallol‐containing
small
molecules
leveraging
different
interactions
between
catechol‐/pyrogallol‐modified
other
substances
form
crosslinked
hydrogels.
Furthermore,
recent
discussed,
future
challenges
research
trends
proposed.
