Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
33(21)
Published: Feb. 22, 2023
Abstract
Infectious
diseases
(such
as
wound
infections)
caused
by
pathogenic
microorganisms
can
lead
to
serious
consequences
and
even
threaten
life.
The
emergence
of
drug‐resistant
bacteria
has
severely
prevented
the
validity
traditional
antibiotics.
Therefore,
developing
novel
antimicrobial
strategies
without
holds
great
promise
for
maximizing
efficacy
minimizing
risk
drug‐resistance
resistant
bacterial
infections.
Herein,
near‐infrared
(NIR)‐absorbing
A–D–A
type
conjugated
oligomers
with
a
tunable
backbone
are
designed
synthesized
regulating
their
photothermal
conversion.
After
being
assembled
into
nanoparticles,
oligomer
CP‐F8P
nanoparticles
(NPs)
containing
strong
electron‐donating
component
show
strongest
conversion
efficiency
81.6%.
low
concentration
NPs
receive
over
99%
against
Amp
r
E.
coli
,
S.
aureus
C.
albicans
upon
NIR
irradiation,
phototherapy
treatment
effectively
promote
healing
in
diabetic
mice
good
biocompatibility.
This
work
provides
ideas
design
efficient
NIR‐activated
reagents
microbial
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
22, P. 141 - 167
Published: Sept. 29, 2022
Currently,
there
are
no
clinical
drugs
available
to
treat
acute
kidney
injury
(AKI).
Given
the
high
prevalence
and
mortality
rate
of
AKI,
development
effectively
AKI
is
a
huge
unmet
medical
need
research
hotspot.
Although
existing
evidence
fully
demonstrates
that
reactive
oxygen
nitrogen
species
(RONS)
burst
at
site
major
contributor
progression,
heterogeneity,
complexity,
unique
physiological
structure
make
most
antioxidant
anti-inflammatory
small
molecule
ineffective
because
lack
targeting
side
effects.
Recently,
nanodrugs
with
intrinsic
through
control
size,
shape,
surface
properties
have
opened
exciting
prospects
for
treatment
AKI.
Many
emerged
address
limitations
current
treatments.
In
this
review,
we
systematically
summarized
first
time
about
emerging
exploit
pathological
features
overcome
traditional
small-molecule
achieve
efficacy.
First,
analyzed
structural
characteristics
main
mechanism
AKI:
hypoxia,
harmful
substance
accumulation-induced
RONS
renal
despite
multifactorial
initiation
heterogeneity
Subsequently,
introduced
strategies
used
improve
reviewed
advances
nano-RONS-sacrificial
agents,
nanozymes,
nanocarriers
antioxidants
drugs.
These
demonstrated
excellent
therapeutic
effects,
such
as
greatly
reducing
oxidative
stress
damage,
restoring
function,
low
Finally,
discussed
challenges
future
directions
translating
into
treatment.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(31)
Published: June 7, 2023
Abstract
Due
to
the
emergence
of
drug
resistance
in
bacteria
and
biofilm
protection,
achieving
a
satisfactory
therapeutic
effect
for
bacteria‐infected
open
wounds
with
conventional
measures
is
problematic.
Here,
photothermal
cascade
nano‐reactor
(CPNC@GOx‐Fe
2+
)
constructed
through
supramolecular
strategy
hydrogen
bonding
coordination
interactions
between
chitosan‐modified
palladium
nano‐cube
(CPNC),
glucose
oxidase
(GOx),
ferrous
iron
(Fe
).
CPNC@GOx‐Fe
exhibits
excellent
effects
powers
GOx‐assisted
reaction
generate
hydroxyl
radicals,
enabling
chemodynamic
combination
therapy
against
biofilms.
Further
proteomics,
metabolomics,
all‐atom
simulation
results
indicate
that
damage
radical
function
structure
cell
membrane
thermal
enhance
fluidity
inhomogeneity
bacterial
membrane,
resulting
synergistic
antibacterial
effect.
In
biofilm‐associated
tooth
extraction
wound
model,
generated
from
process
can
initiate
polymerization
form
hydrogel
situ
protection.
vivo
experiments
confirm
protection
accelerate
healing
infected
tooth‐extraction
without
affecting
oral
commensal
microbiota.
This
study
provides
way
propose
multifunctional
system
treatment
infection.
Materials & Design,
Journal Year:
2023,
Volume and Issue:
233, P. 112231 - 112231
Published: Aug. 9, 2023
Bacterial
infection
continues
to
be
one
of
the
biggest
threats
human
health.
The
therapeutic
effect
is
significantly
reduced
as
a
result
development
super-bacteria-resistant
bacteria
due
overuse
antibiotics
for
conventional
antimicrobial
treatment.
emergence
drug-resistant
makes
it
necessary
develop
new
treatments.
Following
successful
application
photothermal
therapy
in
field
oncology
treatment,
more
and
researchers
are
applying
treatments
achieving
important
results,
especially
treatment
bacterial
infections.
As
non-invasive
anti-infection
method,
has
advantages
broad-spectrum
properties,
short
period,
low
systemic
impact.
In
PTT,
efficacy
strongly
depends
on
different
laser
properties
choice
agents
(PTAs).
purpose
this
review
discuss
most
recent
developments
nanomaterials
that
antibacterial.
We
will
delve
into
principles
spectrum
PTAs
provide
summary
current
synthesis,
classification,
structural
features,
physicochemical
antibacterial
performance
research.
challenges
future
prospects
enhanced
cytotoxicity
investigated.
Biomaterials Research,
Journal Year:
2022,
Volume and Issue:
26(1)
Published: Sept. 30, 2022
Near-infrared-II
(NIR-II,
1000-1700
nm)
light-triggered
photothermal
therapy
(PTT)
has
been
regarded
as
a
promising
candidate
for
cancer
treatment,
but
PTT
alone
often
fails
to
achieve
satisfactory
curative
outcomes.
Hollow
nanoplatforms
prove
be
attractive
in
the
biomedical
field
owing
merits
including
good
biocompatibility,
intrinsic
physical-chemical
nature
and
unique
hollow
structures,
etc.
On
one
hand,
themselves
can
NIR-II
agents
(PTAs),
cavities
of
which
are
able
carry
diverse
therapeutic
units
realize
multi-modal
therapies.
other
PTAs
capable
decorating
on
surface
combine
with
functions
components
encapsulated
inside
synergistic
treatment.
Notably,
generally
serve
photoacoustic
imaging
(PAI)
contrast
(CAs),
means
such
kind
also
expected
multifunctional
all-in-one
nanotheranostics.
In
this
review,
recent
advances
single-modal
PTT,
dual-modal
PTT/photodynamic
(PDT),
PTT/chemotherapy,
PTT/catalytic
PTT/gas
well
PTT/chemodynamic
(CDT)/chemotherapy,
PTT/chemo/gene
PTT/PDT/CDT/starvation
(ST)/immunotherapy
summarized
first
time.
Before
these,
typical
synthetic
strategies
structures
presented,
lastly,
potential
challenges
perspectives
related
these
novel
paradigms
future
research
clinical
translation
discussed.
RSC Advances,
Journal Year:
2023,
Volume and Issue:
13(21), P. 14443 - 14460
Published: Jan. 1, 2023
This
review
summarizes
the
common
inorganic
and
organic
photothermal
nanoagents
their
applications
in
tumor
therapy.
Additionally,
challenges
future
prospects
of
nanomaterial-based
therapy
cancer
treatment
are
discussed.
Biomaterials Research,
Journal Year:
2022,
Volume and Issue:
26(1)
Published: July 6, 2022
Theranostic
nanoplatforms
integrating
diagnostic
and
therapeutic
functions
have
received
considerable
attention
in
the
past
decade.
Among
them,
hollow
manganese
(Mn)-based
are
superior
since
they
combine
advantages
of
structures
intrinsic
theranostic
features
Mn
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(5), P. 5059 - 5071
Published: Feb. 27, 2023
Photosensitizer-based
therapy
often
suffers
from
unitary
and
easily
attenuated
photosensitive
effects,
limited
tumor
penetration
retention,
requirement
of
multiple
irradiation
for
combination
therapy,
which
largely
restrict
its
application.
Here,
bacteria
are
integrated
with
a
monochromatic
irradiation-mediated
ternary
photosensitizers
photoacoustic
imaging-guided
synergistic
photothermal
therapy.
Bacteria
that
bioengineered
to
express
natural
melanin
decorated
dual
synthetic
by
nanodeposition
indocyanine
green
polydopamine
under
cytocompatible
condition.
The
combined
photosensitizers,
share
an
adequate
excitation
at
808
nm,
endow
stable
triple
effect
irradiation.
Due
their
living
characteristics,
these
preferentially
colonize
hypoxic
tissue
homogeneous
distribution
durable
retention
generate
uniform
imaging
signals
sufficient
heating
upon
laser
Supported
significantly
inhibited
growth
extended
survival
animals
in
different
tumor-bearing
murine
models,
our
work
proposes
the
development
bacteria-based
innovative
