Nanomaterials-based photothermal therapies for antibacterial applications

Materials & Design, Journal Year: 2023, Volume and Issue: 233, P. 112231 - 112231

Published: Aug. 9, 2023

Bacterial infection continues to be one of the biggest threats human health. The therapeutic effect is significantly reduced as a result development super-bacteria-resistant bacteria due overuse antibiotics for conventional antimicrobial treatment. emergence drug-resistant makes it necessary develop new treatments. Following successful application photothermal therapy in field oncology treatment, more and researchers are applying treatments achieving important results, especially treatment bacterial infections. As non-invasive anti-infection method, has advantages broad-spectrum properties, short period, low systemic impact. In PTT, efficacy strongly depends on different laser properties choice agents (PTAs). purpose this review discuss most recent developments nanomaterials that antibacterial. We will delve into principles spectrum PTAs provide summary current synthesis, classification, structural features, physicochemical antibacterial performance research. challenges future prospects enhanced cytotoxicity investigated.

Language: Английский

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Harnessing the Power of Stimuli‐Responsive Nanoparticles as an Effective Therapeutic Drug Delivery System

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(24)

Published: March 6, 2024

Abstract The quest for effective and reliable methods of delivering medications, with the aim improving delivery therapeutic agent to intended location, has presented a demanding yet captivating field in biomedical research. concept smart drug systems is an evolving approach, serving as model directing drugs specific targets or sites. These have been developed specifically target regulate administration substances diverse array chronic conditions, including periodontitis, diabetes, cardiac diseases, inflammatory bowel rheumatoid arthritis, different cancers. Nevertheless, numerous comprehensive clinical trials are still required ascertain both immediate enduring impacts such nanosystems on human subjects. This review delves into benefits vehicles, aiming enhance comprehension their applicability addressing present medical requirements. Additionally, it touches upon current applications these stimuli‐reactive biomedicine outlines future development prospects.

Language: Английский

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Enhanced photothermal catalytic CO₂ reduction by CeO₂-based multicomponent catalysts

Journal of Materials Chemistry C, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Based on the understanding of photothermal catalysis, this review summarizes recent progress CeO 2 -based multicomponent catalysts for catalytic CO reduction.

Language: Английский

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Advances in cuproptosis harnessing copper-based nanomaterials for cancer therapy

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.

Language: Английский

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Preclinical advance in nanoliposome-mediated photothermal therapy in liver cancer

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 31, 2025

Language: Английский

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Biomineralized Polydopamine Nanoparticle-Based Sodium Alginate Hydrogels for Delivery of Anti-serine/Threonine Protein Kinase B-Rapidly Accelerated Fibrosarcoma siRNA for Metastatic Melanoma Therapy

ACS Nano, Journal Year: 2023, Volume and Issue: 17(18), P. 18318 - 18331

Published: Sept. 10, 2023

Malignant melanoma, as a highly aggressive skin cancer, is strongly associated with mutations in serine/threonine protein kinase B-RAF (BRAF, where RAF stands for rapidly accelerated fibrosarcoma). Targeted therapy anti-BRAF small interfering RNA (siBRAF) represents crucial aspect of metastatic melanoma treatment. In this study, an injectable hydrogel platform based on sodium alginate (SA), multifunctions photothermal and Ca2+-overload cell apoptosis, was explored siBRAF carrier therapy. We employed polydopamine nanoparticles (PDAs) core constructed calcium phosphate (CaP) shell via biomineralization (PDA@CaP) to load (PDA@siBRAF/CaP). The pH-sensitive CaP facilitated the release Ca2+ under weakly acidic tumor microenvironment, triggering gelation PDA@siBRAF/CaP-SA localized at sites interruption RAS-RAF-MEK-ERK (MAPK) pathway. Besides, continuous could also lead apoptosis. Moreover, effect PDA regulated kinetics, resulting coordinated therapeutic abilities individual components hydrogels. Consequently, effective inhibition growth metastasis achieved vitro vivo using line B16F10 model, by combining ablation, overload, BRAF silencing. Our work provides proof-of-concept system that simultaneously targets multiple mechanisms involved progression has potential be translated into clinical use

Language: Английский

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Synergistic therapeutic strategies and engineered nanoparticles for anti-vascular endothelial growth factor therapy in cancer

Life Sciences, Journal Year: 2024, Volume and Issue: 341, P. 122499 - 122499

Published: Feb. 10, 2024

Language: Английский

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Pillar[n]arene‐Based Supramolecular Nanodrug Delivery Systems for Cancer Therapy

ChemMedChem, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Abstract Macrocyclic supramolecular materials play an important role in encapsulating anticancer drugs to improve the efficiency and reduce toxicity normal tissues through host‐guest interactions. Among them, pillar[n]arenes, as emerging class of macrocyclic compounds, have attracted increasing attention drug delivery drug‐controlled release due their high biocompatibility, excellent chemistry, simplicity modification. In this review, we summarize research progress pillar[n]arene‐based nanodrug systems (SNDs) recent years field tumor therapy, including release, imaging diagnostics therapeutic modalities. Furthermore, opportunities major limitations SNDs for therapy are discussed.

Language: Английский

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Melanin/melanin-like nanoparticles in tumor photothermal and targeted therapies

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125354 - 125354

Published: Feb. 1, 2025

Language: Английский

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Nanomaterials modulate tumor-associated macrophages for the treatment of digestive system tumors

Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 376 - 412

Published: March 21, 2024

The treatment of digestive system tumors presents challenges, particularly in immunotherapy, owing to the advanced immune tolerance system. Nanomaterials have emerged as a promising approach for addressing these challenges. They provide targeted drug delivery, enhanced permeability, high bioavailability, and low toxicity. Additionally, nanomaterials target immunosuppressive cells reshape tumor microenvironment (TIME). Among various TIME, tumor-associated macrophages (TAMs) are most abundant play crucial role progression. Therefore, investigating modulation TAMs by is great significance. Here, we present comprehensive review utilization modulate gastric cancer, colorectal hepatocellular carcinoma, pancreatic cancer. We also investigated underlying mechanisms which treat Furthermore, this summarizes macrophage-derived tumors. Overall, research offers valuable insights into development tailored

Language: Английский

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