Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
11(6), P. 1981 - 1993
Published: Jan. 1, 2023
This
review
describes
the
classification
of
hydrogels,
methods
production
decellularised
extracellular
matrix
(dECM)
and
gel
formation.
Finally,
role
dECM
hydrogels
in
treatment
intervertebral
disc
degeneration
is
summarized.
Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 22, 2024
Intervertebral
disc
degeneration
(IVDD)
is
commonly
associated
with
many
spinal
problems,
such
as
low
back
pain,
and
significantly
impacts
a
patient's
quality
of
life.
However,
current
treatments
for
IVDD,
which
include
conservative
surgical
methods,
are
limited
in
their
ability
to
fully
address
degeneration.
To
combat
delivery-system-based
therapy
has
received
extensive
attention
from
researchers.
These
delivery
systems
can
effectively
deliver
therapeutic
agents
overcoming
the
limitations
these
agents,
reducing
leakage
increasing
local
concentration
inhibit
IVDD
or
promote
intervertebral
(IVD)
regeneration.
This
review
first
briefly
introduces
structure
function
IVD,
related
pathophysiology
IVDD.
Subsequently,
roles
drug-based
bioactive-substance-based
highlighted.
The
former
includes
natural
source
drugs,
nonsteroidal
anti-inflammatory
steroid
medications,
other
small
molecular
drugs.
latter
chemokines,
growth
factors,
interleukin,
platelet-rich
plasma.
Additionally,
gene-based
cell-based
involved.
Finally,
future
development
combination
treatment
discussed,
providing
insights
research.
