Abstract
The
electrical
microenvironment
is
considered
a
pivotal
determinant
in
various
pathophysiological
processes,
including
tissue
homeostasis
and
wound
healing.
Consequently,
extensive
research
endeavors
have
been
directed
toward
applying
electricity
to
cells
tissues
through
external
force
devices
or
biomaterial-based
platforms.
In
addition
situ
electroconductive
matrices,
new
class
of
electroactive
biomaterials
responsive
stimuli
has
emerged
as
focal
point
interest.
These
materials,
response
intrinsic
biochemical
(e.g.,
glucose)
physical
light,
magnetism,
stress),
hold
significant
potential
for
cell
stimulation
regeneration.
this
communication,
we
underscore
distinct
category
biomaterials,
discussing
the
currently
developed
biomaterial
platforms
their
biological
roles
stimulating
during
healing
regeneration
process.
We
also
critically
evaluate
inherent
limitations
challenges
these
while
offering
forward-looking
insights
into
promise
future
clinical
translations.
Graphical
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
25, P. 399 - 414
Published: Nov. 29, 2022
Natural
bone
is
a
composite
tissue
made
of
organic
and
inorganic
components,
showing
piezoelectricity.
Whitlockite
(WH),
which
natural
magnesium-containing
calcium
phosphate,
has
attracted
great
attention
in
formation
recently
due
to
its
unique
piezoelectric
property
after
sintering
treatment
sustained
release
magnesium
ion
(Mg2+).
Herein,
scaffold
(denoted
as
PWH
scaffold)
composed
WH
(PWH)
poly(ε-caprolactone)
(PCL)
was
3D
printed
meet
the
physiological
demands
for
regeneration
neuro-vascularized
tissue,
namely,
providing
endogenous
electric
field
at
defect
site.
The
Mg2+
from
scaffold,
displaying
multiple
biological
activities,
thus
exhibits
strong
synergistic
effect
with
piezoelectricity
on
inhibiting
osteoclast
activation,
promoting
neurogenic,
angiogenic,
osteogenic
differentiation
marrow
mesenchymal
stromal
cells
(BMSCs)
vitro.
In
rat
calvarial
model,
this
remarkably
conducive
efficient
neo-bone
rich
neurogenic
angiogenic
expressions.
Overall,
study
presents
first
example
biomimetic
vivo,
offers
new
insights
regenerative
medicine.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(14)
Published: Jan. 10, 2024
Electrical
stimulation
(ES)
has
shown
beneficial
effects
in
repairing
injured
tissues.
However,
current
ES
techniques
that
use
tissue-traversing
leads
and
bulky
external
power
suppliers
have
significant
limitations
translational
medicine.
Hence,
exploring
noninvasive
vivo
to
provide
controllable
electrical
cues
tissue
engineering
is
an
imminent
necessity.
Herein,
a
conductive
hydrogel
with
situ
generation
capability
as
biodegradable
regeneration
scaffold
wireless
platform
for
spinal
cord
injury
(SCI)
repair
demonstrated.
When
soft
insulated
metal
plate
placed
on
top
of
the
site
transmitter,
implanted
at
can
serve
receiver,
capacitive
coupling
between
receiver
transmitter
generate
alternating
owing
electrostatic
induction
effect.
In
complete
transection
model
SCI
rats,
hydrogels
capacitive-coupling
enhance
functional
recovery
neural
by
promoting
remyelination,
accelerating
axon
regeneration,
facilitating
endogenous
stem
cell
differentiation.
This
facile
wireless-powered
electroactive-hydrogel
strategy
thus
offers
on-demand
adjustable
timeline,
duration,
strength
holds
great
promise
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
25, P. 100950 - 100950
Published: Jan. 11, 2024
Nerve
injuries
pose
a
drastic
threat
to
nerve
mobility
and
sensitivity
lead
permanent
dysfunction
due
low
regenerative
capacity
of
mature
neurons.
The
electrical
stimuli
that
can
be
provided
by
electroactive
materials
are
some
the
most
effective
tools
for
formation
soft
tissues,
including
nerves.
Electric
output
provide
distinctly
favorable
bioelectrical
microenvironment,
which
is
especially
relevant
nervous
system.
Piezoelectric
biomaterials
have
attracted
attention
in
field
neural
tissue
engineering
owing
their
biocompatibility
ability
generate
piezoelectric
surface
charges.
In
this
review,
an
outlook
recent
achievements
described
with
emphasis
on
polymers
engineering.
First,
general
recommendations
design
optimal
scaffold
discussed.
Then,
specific
mechanisms
determining
regeneration
via
stimulation
considered.
Activation
responses
natural
body
movements,
ultrasound,
magnetic
fillers
also
examined.
use
magnetoelectric
combination
alternating
fields
thought
promising
controllable
reproducible
cyclic
deformations
deep
permeation
without
heating.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(33)
Published: March 22, 2024
Abstract
Nerve
injury
can
lead
to
defects
in
related
motor
functions.
It
is
critical
achieve
long‐term
and
convenient
real‐time
evaluation
of
function
recovery
status
during
nerve
repair.
In
this
study,
an
implantable
PLLA/BTO
piezoelectric
sensor
(PBPS)
with
good
biodegradability
biocompatibility
for
real
time
the
after
developed.
PLLA
fibers
doped
BTO
are
employed
as
material
PBPS,
which
convert
biomechanical
signals
generated
by
motion
into
electrical
signals.
PBPS
be
implant
simultaneously
commonly
used
tissue
scaffolds
treatment
rats
sciatic
injury.
The
linearity
pressure
output
voltage
≈0.9445.
For
effectiveness,
process
progresses,
exhibited
consistency
EMG
signals,
indicating
effectively
function.
Moreover,
integration
wireless
module
break
limitations
space
sensing
realize
rat.
based
on
may
bring
new
ideas
development
bioelectronics.
Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
53(17), P. 8632 - 8712
Published: Jan. 1, 2024
Bioelectronics
is
a
hot
research
topic,
yet
an
important
tool,
as
it
facilitates
the
creation
of
advanced
medical
devices
that
interact
with
biological
systems
to
effectively
diagnose,
monitor
and
treat
broad
spectrum
health
conditions.
Electrical
stimulation
(ES)
pivotal
technique
in
bioelectronics,
offering
precise,
non-pharmacological
means
modulate
control
processes
across
molecular,
cellular,
tissue,
organ
levels.
This
method
holds
potential
restore
or
enhance
physiological
functions
compromised
by
diseases
injuries
integrating
sophisticated
electrical
signals,
device
interfaces,
designs
tailored
specific
mechanisms.
review
explains
mechanisms
which
ES
influences
cellular
behaviors,
introduces
essential
principles,
discusses
performance
requirements
for
optimal
systems,
highlights
representative
applications.
From
this
review,
we
can
realize
based
bioelectronics
therapy,
regenerative
medicine
rehabilitation
engineering
technologies,
ranging
from
tissue
neurological
modulation
cardiovascular
cognitive
functions.
underscores
versatility
various
biomedical
contexts
emphasizes
need
adapt
complex
clinical
landscapes
addresses.
ACS Applied Materials & Interfaces,
Journal Year:
2024,
Volume and Issue:
16(8), P. 9839 - 9853
Published: Feb. 19, 2024
Magnetoelectric
stimulation
is
a
promising
therapy
for
various
disorders
due
to
its
high
efficacy
and
safety.
To
explore
potential
in
chronic
skin
wound
treatment,
we
developed
magnetoelectric
dressing,
CFO@CTAB/PVDF
(CCP),
by
electrospinning
cetyltrimethylammonium
bromide-modified
CoFe2O4
(CFO)
particles
with
polyvinylidene
fluoride.
Cetyltrimethylammonium
bromide
(CTAB)
serves
as
dispersion
surfactant
CFO,
quaternary
ammonium
cations
imparting
antibacterial
hydrophilic
properties
the
dressing.
Electrospinning
polarizes
fluoride
(PVDF)
molecules
forms
fibrous
membrane
flexibility
breathability.
With
wearable
electromagnetic
induction
device,
dynamic
magnetic
field
established
induce
magnetostrictive
deformation
of
CFO
nanoparticles.
Consequently,
piezoelectric
generated
on
surface
PVDF
nanofibers
enhance
endogenous
electrical
wound,
achieving
cascade
coupling
electric–magnetic–mechanical–electric
effects.
Bacteria
cell
cultures
show
that
2%
CTAB
effectively
balances
property
fibroblast
activity.
Under
stimulation,
CCP
dressing
demonstrates
significant
upregulation
TGF-β,
FGF,
VEGF,
promoting
L929
adhesion
proliferation.
Moreover,
it
facilitates
healing
diabetic
rat
wounds
infected
Staphylococcus
aureus
within
2
weeks.
Histological
molecular
biology
evaluations
confirm
anti-inflammatory
effect
accelerated
formation
collagen
vessel
stimulation.
This
work
provides
insights
into
application
wounds.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(18)
Published: Jan. 4, 2024
Abstract
Bioelectronic
implants
delivering
electrical
stimulation
offer
an
attractive
alternative
to
traditional
pharmaceuticals
in
electrotherapy.
However,
achieving
simple,
rapid,
and
cost‐effective
personalization
of
these
for
customized
treatment
unique
clinical
physical
scenarios
presents
a
substantial
challenge.
This
challenge
is
further
compounded
by
the
need
ensure
safety
minimal
invasiveness,
requiring
essential
attributes
such
as
flexibility,
biocompatibility,
lightness,
biodegradability,
wireless
capability.
Here,
flexible,
biodegradable
bioelectronic
paper
with
homogeneously
distributed
functionality
simple
introduced.
The
synergistically
combines
i)
lead‐free
magnetoelectric
nanoparticles
(MENs)
that
facilitate
response
external
magnetic
field
ii)
flexible
nanofibers
(NFs)
enable
localization
MENs
high‐selectivity
stimulation,
oxygen/nutrient
permeation,
cell
orientation
modulation,
biodegradation
rate
control.
effectiveness
vitro
through
enhanced
neuronal
differentiation
neuron‐like
PC12
cells
controllability
their
microstructural
are
shown.
Also,
scalability,
design
rapid
customizability
shown
creating
various
3D
macrostructures
using
crafting
techniques
cutting
folding.
platform
holds
promise
temporary
minimally
invasive
therapies.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: March 5, 2024
Abstract
Electrical
stimulation
is
a
fundamental
tool
in
studying
neural
circuits,
treating
neurological
diseases,
and
advancing
regenerative
medicine.
Injectable,
free-standing
piezoelectric
particle
systems
have
emerged
as
non-genetic
wireless
alternatives
for
electrode-based
tethered
systems.
However,
achieving
cell-specific
high-frequency
remains
challenging
due
to
high-intensity
thresholds,
non-specific
diffusion,
internalization
of
particles.
Here,
we
develop
cell-sized
20
μm-diameter
silica-based
magnetic
Janus
microparticles
(PEMPs),
enabling
clinically-relevant
primary
neurons
under
low-intensity
focused
ultrasound.
Owing
its
functionally
anisotropic
design,
half
the
PEMP
acts
electrode
via
conjugated
barium
titanate
nanoparticles
induce
electrical
stimulation,
while
nickel-gold
nanofilm-coated
provides
spatial
orientational
control
on
external
uniform
rotating
fields.
Furthermore,
surface
functionalization
with
targeting
antibodies
enables
binding/targeting
dopaminergic
neurons.
Taking
advantage
such
functionalities,
design
offers
unique
features
towards
minimally
invasive
treatment
diseases.
Exploration,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 30, 2024
Cell
behavior
is
intricately
intertwined
with
the
in
vivo
microenvironment
and
endogenous
pathways.
The
ability
to
guide
cellular
toward
specific
goals
can
be
achieved
by
external
stimuli,
notably
electricity,
light,
ultrasound,
magnetism,
simultaneously
harnessed
through
biomaterial-mediated
responses.
These
triggers
become
focal
points
within
body
due
interactions
biomaterials,
facilitating
a
range
of
pathways:
electrical
signal
transmission,
biochemical
cues,
drug
release,
cell
loading,
modulation
mechanical
stress.
Stimulus-responsive
biomaterials
hold
immense
potential
biomedical
research,
establishing
themselves
as
pivotal
point
interdisciplinary
pursuits.
This
comprehensive
review
systematically
elucidates
prevalent
physical
stimuli
their
corresponding
biomaterial
response
mechanisms.
Moreover,
it
delves
deeply
into
application
domain
biomedicine.
A
balanced
assessment
distinct
stimulation
techniques
provided,
along
discussion
merits
limitations.
aims
shed
light
on
future
trajectory
stimulus-responsive
disease
treatment
outline
prospects
for
development.
poised
spark
novel
concepts
advancing
intelligent,
biomaterials.
