Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101198 - 101198
Published: Aug. 9, 2024
Bioprinting is a groundbreaking technology that enables precise distribution of cell-containing bioinks to construct organoid models accurately reflect the characteristics tumors
Language: Английский
Cellular Oncology, Journal Year: 2024, Volume and Issue: 47(3), P. 759 - 777
Published: Jan. 31, 2024
Language: Английский
Citations
9
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(35)
Published: April 27, 2023
Abstract Cancer kills millions of individuals every year all over the world (Global Observatory). The physiological and biomechanical processes underlying tumor are still poorly understood, hindering researchers from creating new, effective therapies. Inconsistent results preclinical research, in vivo testing, clinical trials decrease drug approval rates. 3D tumor‐on‐a‐chip (ToC) models integrate biomaterials, tissue engineering, fabrication microarchitectures, sensory actuation systems a single device, enabling reliable studies fundamental oncology pharmacology. This review includes critical discussion about their ability to reproduce microenvironment (TME), advantages drawbacks existing architectures, major components techniques. focus is on current materials micro/nanofabrication techniques used manufacture reproducible microfluidic ToC for large‐scale trial applications.
Language: Английский
Citations
19
Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11
Published: May 25, 2023
Three-dimensional (3D) bioprinting is an advanced tissue engineering technique that has received a lot of interest in the past years. We aimed to highlight characteristics articles on 3D bioprinting, especially terms research hotspots and focus. Publications related from 2007 2022 were acquired Web Science Core Collection database. have used VOSviewer, CiteSpace, R-bibliometrix perform various analyses 3,327 published articles. The number annual publications increasing globally, trend expected continue. United States China most productive countries with closest cooperation development investment funds this field. Harvard Medical School Tsinghua University are top-ranked institutions China, respectively. Dr. Anthony Atala Ali Khademhosseini, researchers may provide opportunities for interested researchers. Tissue Engineering Part A contributed largest publication number, while Frontiers Bioengineering Biotechnology was attractive journal potential. As keywords Bio-ink, Hydrogels (especially GelMA Gelatin), Scaffold decellularized extracellular matrix), extrusion-based engineering, vitro models (organoids particularly) analyzed current study. Specifically, topics “new bio-ink investigation,” “modification cell viability vascularization,” “application organoids model” “research personalized regenerative medicine” predicted be future research.
Language: Английский
Citations
19
Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14
Published: May 5, 2023
Hepatocellular carcinoma (HCC) is a major global health burden, causing approximately 8.3 million deaths each year, and it the third leading cause of cancer-related death worldwide, with relative 5-year survival rate around 18%. Due to advanced stage diagnosis in most patients, systemic treatment based on targeted therapy has become only feasible option. Genomic studies have established profile molecular alterations hepatocellular potentially actionable mutations, but these mutations yet be translated into clinical practice. The first drug approved for patients was Sorafenib, which milestone. Subsequent trials identified multiple tyrosine kinase inhibitors, such as Lenvatinib, Cabozantinib, Regorafenib, carcinoma, benefits patient. Ongoing include various immune-based combination therapies, some early results showing promise potential new plans. Systemic complicated by significant heterogeneity disease its propensity developing resistance. Therefore, essential choose better, individualized plan benefit patients. Preclinical models capable preserving vivo tumor characteristics are urgently needed circumvent overcome In this review, we summarize current approaches HCC establishment several patient-derived preclinical carcinoma. We also discuss challenges opportunities how achieve personalized continuous development therapies bioengineering technologies.
Language: Английский
Citations
14
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(7), P. 6071 - 6071
Published: March 23, 2023
Lung cancer still has one of the highest morbidity and mortality rates among all types cancer. Its incidence continues to increase, especially in developing countries. Although medical field witnessed development targeted therapies, new treatment options need be developed urgently. For discovery drugs, human models are required study drug efficiency a relevant setting. Here, we report generation non-small cell lung model with perfusion system. The bioprinted was produced by digital light processing (DLP). This technique advantage including simulated blood vessels, its simple assembly maintenance allow for easy testing candidates. In proof-of-concept study, applied gemcitabine determined IC50 values 3D 2D monolayer cultures compared response under static dynamic cultivation perfusion. As must penetrate hydrogel reach cells, value three orders magnitude higher constructs than cultures. Compared cultivation, viability cells significantly increased approximately 60% Dynamic also enhanced cytotoxicity tested drug, drug-mediated apoptosis fourfold fraction signal marker caspase-3 sixfold positive PARP-1. Altogether, this easily reproducible can used initial anticancer substances. subsequent in-depth characterization candidate further improvements will necessary, such as multi-cell type lining vascular structures endothelial cells.
Language: Английский
Citations
11
APL Bioengineering, Journal Year: 2023, Volume and Issue: 7(3)
Published: Sept. 1, 2023
Magneto-responsive soft hydrogels are used for a number of biomedical applications, e.g., magnetic hyperthermia, drug delivery, tissue engineering, and neuromodulation. In this work, type hydrogel has been fabricated from hyaluronan (HA) filled with binary system Al2O3 nanoparticles multicore particles (MCPs), which were obtained by clustering superparamagnetic iron oxide FeOx NPs. It was established that the presence diamagnetic several positive effects: it enhances storage modulus long-term stability in cell cultivation medium; prevents interaction among MCPs. The HA provides rapid heating 0.3 °C per min under exposure to low amplitude radio frequency alternating field. Furthermore, magneto-responsive successfully encapsulate cells extrusion-based 3D printing 87±6% viability, thus providing bio-ink. combination high efficiency, softness, cytocompatibility, printability leads material suitable applications.
Language: Английский
Citations
11
Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 730, P. 150339 - 150339
Published: July 8, 2024
The tumor microenvironment (TME) assumes a pivotal role in the treatment of oncological diseases, given its intricate interplay diverse cellular components and extracellular matrices. This dynamic ecosystem poses serious challenge to traditional research methods many ways, such as high costs, inefficient translation, poor reproducibility, low modeling success rates. These challenges require search for more suitable accurately model TME, emergence 3D bioprinting technology is transformative an important complement these precisely control distribution cells, biomolecules, matrix scaffolds within TME. Leveraging digital design, enables personalized studies with precision, providing essential experimental flexibility. Serving critical bridge between vitro vivo studies, facilitates realistic culturing cancer cells. comprehensive article delves into cutting-edge developments bioprinting, encompassing methodologies, biomaterial choices, various models. Exploration current challenges, including limited options, printing accuracy constraints, ethical considerations, contributes nuanced understanding. Despite holds immense potential simulating tissues, propelling medicine, constructing high-resolution organ models, marking trajectory research.
Language: Английский
Citations
4
Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
Abstract As an emerging technology for modeling cancer tissue in vitro, 3D bioprinting facilitates precise spatial manipulation of cells and biomaterials, allowing the replication complex architectures accurate recapitulation tumor microenvironment (TME) features. This review initially elucidates mechanisms underlying tumorigenesis associated TME complexity, with a particular focus on roles stromal cell populations characteristics extracellular matrix (ECM) progression. Moreover, this work summarizes recent advances bioprinted models, emphasizing their application studying cell‐ECM interactions, stromal‐tumor crosstalk, vasculature formation investigating occurrence metastasis, as well utility high‐throughput drug screening therapeutic development. Finally, discusses advantages challenges creating biomimetic while providing insights into future development trajectories potential translational applications research personalized medicine. By focusing these critical dimensions, aims to highlight transformative role advancing vitro models ultimate goal improving treatment, prevention, patient outcomes.
Language: Английский
Citations
0
ACS Materials Au, Journal Year: 2023, Volume and Issue: 3(6), P. 620 - 635
Published: Aug. 28, 2023
Cancer is a complex disease with global significance, necessitating continuous advancements in diagnostics and treatment. 3D printing technology has emerged as revolutionary tool cancer diagnostics, offering immense potential detection monitoring. Traditional diagnostic methods have limitations providing molecular genetic tumor information that crucial for personalized treatment decisions. Biomarkers become invaluable but their often requires specialized facilities resources. enables the fabrication of customized sensor arrays, enhancing multiple biomarkers specific to different types cancer. These 3D-printed arrays offer improved sensitivity, allowing low levels biomarkers, even samples. Moreover, specificity can be fine-tuned, reducing false-positive false-negative results. The streamlined cost-effective process makes these accessible, potentially improving on scale. By harnessing printing, researchers clinicians enhance early detection, monitor response, improve patient outcomes. integration holds significant promise future care.
Language: Английский
Citations
10
Biofabrication, Journal Year: 2024, Volume and Issue: 16(2), P. 022004 - 022004
Published: Feb. 2, 2024
The tumor microenvironment (TME) is critical for growth and metastasis. TME contains cancer-associated cells, matrix, secretory factors. fabrication of artificial tumors, so-called tumoroids, great significance the understanding tumorigenesis clinical cancer therapy. assembly multiple cells matrix components through interdisciplinary techniques necessary preparation various tumoroids. This article discusses current methods constructing tumoroids (tumor tissue slices cell co-culture) pre-clinical use. focuses on materials (natural synthetic materials) biofabrication (cell assembly, bioengineered tools, bioprinting, microfluidic devices) used in also points out shortcomings potential solutions. aims to promotes next-generation them basic research application.
Language: Английский
Citations
3