Smart wound dressing for advanced wound management: Real-time monitoring and on-demand treatment

Materials & Design, Journal Year: 2023, Volume and Issue: 229, P. 111917 - 111917

Published: April 7, 2023

Timely and accurate assessment of wounds during the wound healing process is key for correct diagnosis treatment decisions repair. However, traditional management strategies often fail to provide timely information on status, thereby delaying or misleading treatments. Smart dressings that enable in situ real-time monitoring wound-related biomarkers, early on-demand adverse events, such as bacterial infection inflammation, by integrating wearable sensors, advanced drug delivery systems wireless communication technology have recently been developed could improve management. In this review, we provided an overview including temperature, pH, uric acid, glucose, reactive oxygen (ROS), enzymes, related events exiting sensors detecting these biomarkers based colorimetric, fluorimetric electrochemical approaches. Examples smart integrate controllable functions triggered both endogenous exogenous stimuli, all-in-one dressing capable treatment, major challenges exciting opportunities are presented comprehensively discussed.

Language: Английский

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Fluorescent quantum dots-based hydrogels: Synthesis, fabrication and multimodal biosensing

Talanta Open, Journal Year: 2023, Volume and Issue: 8, P. 100243 - 100243

Published: July 8, 2023

Hydrogels have a significant impact on the fields of biological study and medical diagnosis. They are becoming more useful in bioanalytical biosensing applications. The intriguing new nanomaterials quantum dots-hydrogel composites gained lot interest because their unmatched biocompatibility tolerable biodegradability, which opens up wide range possible Focusing synthesis techniques, this review describes current developments composites, such as hydrogel gelation dots (QDs) solution, inserting prepared QDs into hydrogels after gelation, generating situ inside preformed gel, cross-linking through QDs. Biomedical applications bioimaging specifically examined, then inherent problems design optimisation, biocompatibility, bimodal applications, well potential future development, discussed.

Language: Английский

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Challenges and Advances of Hydrogel-Based Wearable Electrochemical Biosensors for Real-Time Monitoring of Biofluids: From Lab to Market. A Review

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(20), P. 8160 - 8183

Published: Feb. 20, 2024

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTChallenges and Advances of Hydrogel-Based Wearable Electrochemical Biosensors for Real-Time Monitoring Biofluids: From Lab to Market. A ReviewHossein ChenaniHossein ChenaniDepartment Materials Science Engineering, Sharif University Technology, 14588 89694 Tehran, IranMore by Hossein ChenaniView Biographyhttps://orcid.org/0009-0009-6924-6491, Mohsen Saeidi*Mohsen SaeidiDepartment Iran*Tel: +98-21-6616 5262; Fax: +98-21-6600 5717; Email: [email protected]More SaeidiView Biographyhttps://orcid.org/0000-0001-5430-3339, MahsaSadat Adel RastkhizMahsaSadat RastkhizDepartment RastkhizView Biographyhttps://orcid.org/0009-0002-6628-6868, Nafiseh BolghanabadiNafiseh BolghanabadiDepartment BolghanabadiView Biographyhttps://orcid.org/0009-0004-1151-2201, Amir AghaiiAmir AghaiiDepartment AghaiiView Biographyhttps://orcid.org/0009-0006-2561-9119, Mina OroujiMina OroujiDepartment OroujiView Biographyhttps://orcid.org/0009-0007-6375-6437, HatamieAmir HatamieDepartment Chemistry Molecular Biology, Gothenburg, Sweden; Department Chemistry, Institute Advanced Studies in Basic Sciences (IASBS), Prof. Sobouti Boulevard, PO Box 45195-1159, Zanjan 45137-66731, HatamieView Biographyhttps://orcid.org/0000-0002-7085-893X, Abdolreza Simchi*Abdolreza SimchiDepartment IranCenter Bioscience Convergence Tehran 14588-89694, 5226; SimchiView Biographyhttps://orcid.org/0000-0002-9111-2977Cite this: Anal. Chem. 2024, 96, 20, 8160–8183Publication Date (Web):February 2024Publication History Received2 September 2023Accepted1 February 2024Revised24 January 2024Published online20 inissue 21 May 2024https://pubs.acs.org/doi/10.1021/acs.analchem.3c03942https://doi.org/10.1021/acs.analchem.3c03942review-articleACS PublicationsCopyright © 2024 American Chemical SocietyRequest reuse permissionsArticle Views1518Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article downloads since November 2008 (both PDF HTML) across all institutions individuals. These metrics regularly updated reflect usage leading up last few days.Citations number other articles citing this article, calculated Crossref daily. Find more information about citation counts.The Altmetric Attention Score is a quantitative measure attention that research has received online. Clicking on donut icon will load page at altmetric.com with additional details score social media presence given article. how calculated. Share Add toView InAdd Full Text ReferenceAdd Description ExportRISCitationCitation abstractCitation referencesMore Options onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Biotechnology,Carbohydrates,Electrodes,Hydrogels,Sensors Get e-Alerts

Language: Английский

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Tough Hydrogels for Load‐Bearing Applications

Advanced Science, Journal Year: 2024, Volume and Issue: 11(12)

Published: Jan. 15, 2024

Abstract Tough hydrogels have emerged as a promising class of materials to target load‐bearing applications, where the material has resist multiple cycles extreme mechanical impact. A variety chemical interactions and network architectures are used enhance properties fracture mechanics making them stiffer tougher. In recent years, tough, high‐performance been benchmarked, however, this is often incomplete important variables like water content largely ignored. review, aim clarify reported state‐of‐the‐art tough by providing comprehensive library property data. First, common methods for characterization such introduced. Then, various modes energy dissipation obtain discussed categorize individual datasets helping asses material's (fracture) properties. Finally, current applications considered, compared with existing materials, future opportunities discussed.

Language: Английский

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Wireless Battery-free and Fully Implantable Organ Interfaces

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2205 - 2280

Published: Feb. 21, 2024

Advances in soft materials, miniaturized electronics, sensors, stimulators, radios, and battery-free power supplies are resulting a new generation of fully implantable organ interfaces that leverage volumetric reduction mechanics by eliminating electrochemical storage. This device class offers the ability to provide high-fidelity readouts physiological processes, enables stimulation, allows control over organs realize therapeutic diagnostic paradigms. Driven seamless integration with connected infrastructure, these devices enable personalized digital medicine. Key advances carefully designed material, electrophysical, electrochemical, electromagnetic systems form implantables mechanical properties closely matched target deliver functionality supports sensors stimulators. The elimination operation, anywhere from acute, lifetimes matching subject physical dimensions imperceptible operation. review provides comprehensive overview basic building blocks related topics such as implantation, delivery, sterilization, user acceptance. State art examples categorized system an outlook interconnection advanced strategies for computation leveraging consistent influx elevate this current battery-powered is highlighted.

Language: Английский

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Theranostic hydrogels: Construction strategies and applications

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159545 - 159545

Published: Jan. 13, 2025

Language: Английский

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A Review of Functional Hydrogels for Flexible Chemical Sensors

Advanced Sensor Research, Journal Year: 2023, Volume and Issue: 3(3)

Published: May 3, 2023

Abstract Hydrogels have drawn considerable attention in the field of flexible chemical sensors due to their unique 3D structure, high permeability, ion‐conductivity, and tissue‐like mechanical properties. These structures properties allow them be functionalized into diverse sensing components respond signals complex environments. Herein, an overview functional hydrogel‐based is provided. First, representative hydrogel materials are introduced operating principles for discussed. Then, state‐of‐the‐art applications highlighted including gas sensors, humidity pH glucose wound monitoring, others. Finally, major challenges opportunities this

Language: Английский

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Electrochemical Wearable Biosensors and Bioelectronic Devices Based on Hydrogels: Mechanical Properties and Electrochemical Behavior

Biosensors, Journal Year: 2023, Volume and Issue: 13(8), P. 823 - 823

Published: Aug. 15, 2023

Hydrogel-based wearable electrochemical biosensors (HWEBs) are emerging biomedical devices that have recently received immense interest. The exceptional properties of HWEBs include excellent biocompatibility with hydrophilic nature, high porosity, tailorable permeability, the capability reliable and accurate detection disease biomarkers, suitable device–human interface, facile adjustability, stimuli responsive to nanofiller materials. Although biomimetic three-dimensional hydrogels can immobilize bioreceptors, such as enzymes aptamers, without any loss in their activities. However, most suffer from low mechanical strength electrical conductivity. Many studies been performed on electroactive nanofillers, including biomacromolecules, carbon-based materials, inorganic organic nanomaterials, tackle these issues. Non-conductive even conductive may be modified by well redox species. All modifications led design development efficient nanocomposites biosensors. In this review, both conductive-based non-conductive-based derived natural synthetic polymers systematically reviewed. main synthesis methods characterization techniques addressed. behavior discussed detail. Finally, prospects potential applications biosensing, healthcare monitoring, clinical diagnostics highlighted.

Language: Английский

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Advances in electrochemical sensors for real-time glucose monitoring

Sensors & Diagnostics, Journal Year: 2024, Volume and Issue: 3(6), P. 893 - 913

Published: Jan. 1, 2024

This manuscript emphasizes advancements in electrochemical sensors for real-time glucose monitoring, showcasing their pivotal role enhancing personalized healthcare through continuous, reliable measurement of biochemical markers.

Language: Английский

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Integrated Electrochemical Aptamer Biosensing and Colorimetric pH Monitoring via Hydrogel Microneedle Assays for Assessing Antibiotic Treatment

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Abstract Current methods for therapeutic drug monitoring (TDM) have a long turnaround time as they involve collecting patients' blood samples followed by transferring the to medical laboratories where sample processing and analysis are performed. To enable real‐time minimally invasive TDM, microneedle (MN) biosensor monitor levels of two important antibiotics, vancomycin (VAN) gentamicin (GEN) is developed. The MN composed hydrogel (HMN), an aptamer‐functionalized flexible (Flex) electrode, named HMN‐Flex. HMN extracts dermal interstitial fluid (ISF) transfers it Flex electrode sensing target antibiotics happens. HMN‐Flex performance validated ex vivo using skin models well in live rat animal models. Data leveraged from system construct pharmacokinetic profiles VAN GEN compare these with conventional blood‐based measurements. Additionally, track pH patient's response during antibiotic treatment, developed that employs colorimetric method detect changes pH, HMN‐pH assay, whose has been both vitro vivo. Further, multiplexed detection achieved simultaneously employing on animals.

Language: Английский

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