PEDOTs‐Based Conductive Hydrogels: Design, Fabrications, and Applications

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

Abstract Conductive hydrogels combine the benefits of soft with electrical conductivity and have gained significant attention over past decade. These innovative materials, including poly(3,4‐ethylenedioxythiophene) (PEDOTs)‐based conductive (P‐CHs), are promising for flexible electronics biological applications due to their tunable flexibility, biocompatibility, hydrophilicity. Despite recent advances, intrinsic correlation between design, fabrications, P‐CHs has been mostly based on trial‐and‐error‐based Edisonian approaches, significantly limiting further development. This review comprehensively examines design strategies, fabrication technologies, diverse P‐CHs. By summarizing such as molecular, network, phase, structural engineering, exploring both 2D 3D techniques, this offers a comprehensive overview in fields bioelectronics, actuators, energy devices, solar evaporators. Establishing critical internal connection fabrication, application aims guide future research stimulate innovation field functional P‐CHs, offering broad multidisciplinary researchers.

Language: Английский

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Tailoring Design of Microneedles for Drug Delivery and Biosensing

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Microneedles (MNs) are emerging as versatile tools for both therapeutic drug delivery and diagnostic monitoring. Unlike hypodermic needles, MNs achieve these applications with minimal or no pain customizable designs, making them suitable personalized medicine. Understanding the key design parameters challenges during contact biofluids is crucial to optimizing their use across applications. This review summarizes current fabrication techniques considerations tailored meet distinct requirements biosensing We further underscore state of theranostic that integrate propose future directions advancing toward clinical use.

Language: Английский

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Smart Microneedles in Biomedical Engineering: Harnessing Stimuli‐Responsive Polymers for Novel Applications

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)

Published: Dec. 1, 2024

ABSTRACT This review aims to provide a comprehensive analysis of recent advancements in smart microneedles (MNs) within the biomedical field, focusing on integration stimuli‐responsive polymers for enhanced therapeutic and diagnostic applications. Conventional drug delivery methods are known face limitations precision, safety, patient compliance, which can be addressed by innovative features MNs. Through use various polymers, these MNs have been designed react environmental or physiological cues, allowing on‐demand release, biomarker sensing, localized interventions. Fundamental materials used fabrication MNs, including metals, composite hydrogels, reviewed, different categories stimuli‐responsiveness, such as photo, electro, thermal, mechanical, biochemical, explored. Application‐specific designs areas delivery, cancer therapy, diabetes management, skin disease treatments also examined. this discussion, it is highlighted that poised play significant role advancing personalized noninvasive medical treatments.

Language: Английский

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Lighting the Path to Precision Healthcare: Advances and Applications of Wearable Photonic Sensors

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Abstract Recent advancements in wearable photonic sensors have marked a transformative era healthcare, enabling non‐invasive, real‐time, portable, and personalized medical monitoring. These leverage the unique properties of light toward high‐performance sensing form factors optimized for real‐world use. Their ability to offer solutions broad spectrum challenges – from routine health monitoring managing chronic conditions, inspires rapidly growing translational market. This review explores design development various healthcare applications. The strategies that power these technologies are first presented, alongside discussion define optimal use‐cases each approach. means by which mechanisms integrated into formats then discussed, with considerations material selection comfort functionality, component fabrication, management. developments space detailed, accounting both physical chemical stimuli detection through non‐invasive biofluids. Finally, comprehensive situational overview identifies critical translation, promising solutions. Associated future outlooks detail emerging trends stand enable integration mainstream practice, advancing medicine improving patient outcomes.

Language: Английский

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Recent progress in hydrogel microneedle sensors based on electrochemical and optical sensing

Applied Spectroscopy Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 41

Published: April 3, 2025

Language: Английский

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Microneedle technology for enhanced topical treatment of skin infections

Bioactive Materials, Journal Year: 2024, Volume and Issue: 45, P. 274 - 300

Published: Nov. 26, 2024

Language: Английский

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Surface-Functionalizing Strategies for Multiplexed Molecular Biosensing: Developments Powered by Advancements in Nanotechnologies

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(24), P. 2014 - 2014

Published: Dec. 14, 2024

Multiplexed biosensing methods for simultaneously detecting multiple biomolecules are important investigating biological mechanisms associated with physiological processes, developing applications in life sciences, and conducting medical tests. The development of biosensors, especially those advanced biosensors multiplexing potentials, strongly depends on advancements nanotechnologies, including the nano-coating thin films, micro–nano 3D structures, nanotags signal generation. Surface functionalization is a critical process applications, one which enables immobilization probes or other structures that assist capturing biomolecules. During this functionalizing process, nanomaterials can either be objects surface modification materials used to modify base surfaces. These surface-functionalizing strategies, involving coordination sensor materials, as well modifying methods, largely determinative performance applications. This review introduces current studies potentials focuses specifically roles design these biosensors. A detailed description paradigms method selection has been set forth understanding accelerate application novel nanotechnologies

Language: Английский

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Advances in Research of Hydrogel Microneedle-Based Delivery Systems for Disease Treatment

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1571 - 1571

Published: Dec. 9, 2024

Microneedles (MNs), composed of multiple micron-scale needle-like structures attached to a base, offer minimally invasive approach for transdermal drug delivery by penetrating the stratum corneum and delivering therapeutic agents directly epidermis or dermis. Hydrogel microneedles (HMNs) stand out among various MN types due their excellent biocompatibility, high drug-loading capacity, tunable drug-release properties. This review systematically examines matrix materials fabrication methods HMN systems, highlighting advancements in natural synthetic polymers, explores applications treating conditions such as wound healing, hair loss, cardiovascular diseases, cancer. Furthermore, potential HMNs disease diagnostics is discussed. The identifies key challenges, including limited mechanical strength, efficiency, lack standardization, while proposing strategies overcome these issues. With integration intelligent design enhanced control over dosage safety, are poised revolutionize expand personalized medicine.

Language: Английский

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