TiO2-Nanoparticle–Enhanced Sonodynamic Therapy for Prevention of Posterior Capsular Opacification and Ferroptosis Exploration of Its Mechanism DOI Creative Commons
Y. Li,

Pingjun Chang,

Liming Xu

et al.

Investigative Ophthalmology & Visual Science, Journal Year: 2024, Volume and Issue: 65(12), P. 24 - 24

Published: Oct. 17, 2024

To explore the application and potential ferroptosis mechanisms of sonodynamic therapy (SDT) using titanium dioxide nanoparticles (TiO2-NPs) as sonosensitizers for prevention posterior capsule opacification (PCO).

Language: Английский

Tumor Microenvironment Specific Regulation Ca‐Fe‐Nanospheres for Ferroptosis‐Promoted Domino Synergistic Therapy and Tumor Immune Response DOI
Xu Chu,

Hua‐Ying Hou,

Meng‐Die Duan

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: May 27, 2024

Abstract Reactive oxygen species (ROS)‐mediated emerging treatments exhibit unique advantages in cancer therapy recent years. While the efficacy of ROS‐involved tumor is greatly restricted by complex microenvironment (TME). Herein, a dual‐metal CaO 2 @CDs‐Fe (CCF) nanosphere, with TME response and regulation capabilities, are proposed to improve ROS lethal power multiple cascade synergistic therapeutic strategy domino effect. In weak acidic TME, CCF will decompose, accompanied intracellular Ca 2+ upregulated abundant H O produced reverse antitherapeutic TME. Then exposed CF cores can act as both Fenton agent sonosensitizer generate excessive regulated for enhanced CDT/SDT. combination calcium overloading, augmented induced oxidative stress cause more severe mitochondrial damage cellular apoptosis. Furthermore, also reduce GPX4 expression enlarge lipid peroxidation, causing ferroptosis apoptosis parallel. These signals finally initiate damage‐associated molecular patterns activate immune realize excellent antitumor This outstanding ROS/calcium loading effect endows anticancer efficiently eliminate apoptosis/ferroptosis/ICD vitro vivo.

Language: Английский

Citations

9
Tumor Microenvironment‐Activatable Metal‐Phenolic Nanoformulations for Ultrasound‐Boosted Ferroptosis through Triple Regulatory Pathways DOI

Zhendong Liu,

Sainan Liu,

Bin Liu

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: July 16, 2024

Abstract Despite its effectiveness in exterminating tumor cells, ferroptosis is seriously hampered by the high expression of antioxidant glutathione (GSH) and inadequacy endogenous H 2 O tumors. Herein, metal‐phenolic nanoformulations (FNCP NFs) composed sonosensitizer Chlorin e6 (Ce6), phenolic GSH consumer naphthazarin, Fe 3+ , followed modification PEG2000, are strategically designed fabricated for ultrasound‐boosted cells through triple regulatory pathways. The carrier‐free FNCP NFs can rapidly dissociate under microenvironment response with assistance ultrasound, releasing 2+ Ce6, naphthazarin. Ce6 capable producing singlet oxygen ( 1 ) hydroxyl radicals · OH) ultrasound‐activated sonodynamic therapy Fenton reaction‐mediated chemodynamic (CDT), respectively, which not only induce apoptotic cell death but also lead to effective accumulation lipid peroxidation (LPO), resulting ferroptosis. Meanwhile, released naphthazarin self‐cycling valence alternations /Fe promote significant decrease intracellular contents, further inducing inactivation peroxidase 4 (GPX4) up‐regulation LPO levels, eventually realizing synergistically enhanced This facile feasible design versatile offers a new strategy effectively improving efficiency multimodal cancer therapies.

Language: Английский

Citations

9
Photonic control of image-guided ferroptosis cancer nanomedicine DOI Creative Commons
Min Jun Ko, Woojung Yoo, Sunhong Min

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 500, P. 215532 - 215532

Published: Nov. 10, 2023

Language: Английский

Citations

19
A ferroptosis-reinforced nanocatalyst enhances chemodynamic therapy through dual H2O2 production and oxidative stress amplification DOI
X. L. Zhu, Tianyu Wang, Hao‐Ran Jia

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 892 - 904

Published: Feb. 24, 2024

Language: Английский

Citations

7
Light-activated nanoclusters with tunable ROS for wound infection treatment DOI Creative Commons

Xin Wang,

Jianing Ding,

Xiao Chen

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 41, P. 385 - 399

Published: July 30, 2024

Infected wounds pose a significant clinical challenge due to bacterial resistance, recurrent infections, and impaired healing. Reactive oxygen species (ROS)-based strategies have shown promise in eradicating infections. However, the excess ROS infection site after treatments may cause irreversible damage healthy tissues. To address this issue, we developed bovine serum albumin-iridium oxide nanoclusters (BSA-IrO

Language: Английский

Citations

7
Biodegradable iridium coordinated nanodrugs potentiate photodynamic therapy and immunotherapy of lung cancer DOI

Jingyao Li,

Huixi Yi,

Yuanyuan Fu

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 680, P. 9 - 24

Published: Oct. 30, 2024

Language: Английский

Citations

7
Folate-targeted iridium complexes amplify photodynamic therapy efficacy through ferroptosis DOI
Xiangdong He, Lai Wei, Jun Chen

et al.

Inorganic Chemistry Frontiers, Journal Year: 2023, Volume and Issue: 10(16), P. 4780 - 4788

Published: Jan. 1, 2023

Interest in targeted cancer therapies with fewer side effects has increased recent years.

Language: Английский

Citations

16
Ternary heterostructure-driven photoinduced electron-hole separation enhanced oxidative stress for triple-negative breast cancer therapy DOI Creative Commons
Shuqing Dong, Yuqi Huang,

Hanrong Yan

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: May 12, 2024

Abstract Zinc oxide nanoparticles (ZnO NPs) stand as among the most significant metal in trigger formation of reactive oxygen species (ROS) and induce apoptosis. Nevertheless, utilization ZnO NPs has been limited by shallowness short-wavelength light constrained production ROS. To overcome these limitations, a strategy involves achieving red shift towards near-infrared (NIR) spectrum, promoting separation restraining recombination electron-hole (e − -h + ) pairs. Herein, hybrid plasmonic system Au@ZnO (AZ) with graphene quantum dots (GQDs) doping (AZG) nano heterostructures is rationally designed for optimal NIR-driven cancer treatment. Significantly, multifold increase ROS generation can be achieved through following creative initiatives: (i) Au nanorods expands photocatalytic capabilities AZG into NIR domain, offering foundation NIR-induced clinical utilization; (ii) elaborate design mesoporous core-shell AZ structures facilitates redistribution pairs; (iii) incorporation GQDs structure could efficiently restrain e (iv) Modification hyaluronic acid (HA) enhance CD44 receptor mediated targeted triple-negative breast (TNBC). In addition, introduced NRs present catalysts enhancing photothermal therapy (PTT), effectively inducing apoptosis tumor cells. The resulting HA-modified (AZGH) exhibits efficient hot electron injection separation, affording unparalleled convenience enabling PDT treanment. As result, our well-designed AZGH photosensitizers exhibit excellent efficacy.

Language: Английский

Citations

6
A promising new approach to cancer therapy: Manipulate ferroptosis by hijacking endogenous iron DOI
Luwen Zhu, Yong‐Zhong Du

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124517 - 124517

Published: July 29, 2024

Language: Английский

Citations

5
Ferroptosis resistance in cancer: recent advances and future perspectives DOI
Zhang Xing, Xiang Li, Xia Ran

et al.

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 219, P. 115933 - 115933

Published: Nov. 22, 2023

Language: Английский

Citations

12