Materials Today, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125285 - 125285
Published: Jan. 1, 2025
Language: Английский
Citations
2
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
MXenzymes, a promising class of catalytic therapeutic material, offer great potential for tumor treatment, but they encounter significant obstacles due to suboptimal efficiency and kinetics in the microenvironment (TME). Herein, this study draws inspiration from electronic structure transition metal vanadium, proposing leverage TME specific-features induce structural transformations sheet-like vanadium carbide MXenzymes (TVMz). These trigger cascading reactions that amplify oxidative stress, thereby significantly enhancing multimodal therapy. Specifically, engineered HTVMz, coated with hyaluronic acid, exhibits good stability generates thermal effect under NIR-II laser irradiation. The effect, combined characteristics, facilities transformation into ultra-small oxide nanozymes (VOx). enlarged surface area VOx substantially enhances ROS regeneration amplifies which promotes lysosomal permeability induces endoplasmic reticulum stress. high-valent interacts intracellular glutathione, disrupting redox homeostasis intensifying stress further. amplifications accelerate apoptosis, ferroptosis, suppress HSP90 expression. Consequently, heightened sensitivity HTVMz synergistically cell death via pathways. This presents an innovative strategy therapy by manipulating structures, advancing field
Language: Английский
Citations
1
Biomaterials Research, Journal Year: 2024, Volume and Issue: 28
Published: Jan. 1, 2024
Background: Chemodynamic therapy (CDT) is recognized as a promising cancer treatment. Recently, copper sulfide nanostructures have been extensively employed Fenton-like reagents that catalyze the formation of acutely toxic hydroxyl radicals (·OH) from hydrogen peroxide (H 2 O ). However, CDT therapeutic potency restricted by tumor microenvironment (TME), such insufficient amounts peroxide, excessive glutathione levels, etc. To address these disadvantages, glucose oxidase (GOx) or catalase (CAT) can be utilized to enhance CDT, while low efficacy still inhibits their future applications. Our previous study revealed mild photothermal effect could boost catalytic effectiveness well GOx enzyme activity over range. Results: We engineered and constructed hollow CuS nanoplatform loaded with CAT, coating macrophage membranes (M@GOx-CAT@CuS NPs). The nanoplatforms allowed enhancement reactive oxygen species creation rate activeness through phototherapy directed photoacoustic imaging. After actively targeting vascular cell adhesion molecule-1 (VCAM-1) in cells mediated membrane coating, M@GOx-CAT@CuS NPs released CAT under near-infrared irradiation. catalyzed H gluconic acid glucose, creating better environment for CDT. Meanwhile, CAT-catalyzed decomposition generate sufficient oxygen, appropriately alleviating shortage TME. In addition, starvation effects decreased adenosine triphosphate levels further underregulated heat shock protein expression reduce resistance cells, resulting outcome. Both vitro vivo experiments demonstrated newly developed has remarkable synergistic anticancer effects. Conclusion: cascade reaction-enhanced biomimetic opens up new avenue precision diagnostic research.
Language: Английский
Citations
1
Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12
Published: Aug. 16, 2024
Ionizing radiation is a significant risk factor for cataracts, but the pathogenesis of radiation-induced cataracts remains incompletely understood. Ferroptosis, an iron-dependent form programmed cell death discovered in recent years, has gained increasing attention its role various diseases. This article systematically reviews research progress on ionizing radiation, ferroptosis, age-related and cataracts. It proposes “ferroptosis hypothesis” Through ionization oxidative stress effects, leads to elevated free iron levels exacerbated lipid peroxidation lens cells, activating ferroptosis pathway resulting opacity. The involvement development suggests that it may also be important pathogenic mechanism Targeting novel strategy preventing treating Furthermore, developing new ferroptosis-specific inhibitors with improved targeting pharmacokinetic properties essential direction study provides insights into management potentially transforming from “inevitable” “preventable treatable.”
Language: Английский
Citations
1
Talanta, Journal Year: 2024, Volume and Issue: 281, P. 126839 - 126839
Published: Sept. 10, 2024
Language: Английский
Citations
1
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Dec. 19, 2024
Radiotherapy (RT) is a primary clinical approach for cancer treatment, but its efficacy often hindered by various challenges, especially radiation resistance, which greatly compromises the therapeutic effectiveness of RT. Mitochondria, central to cellular energy metabolism and regulation cell death, play critical role in mechanisms radioresistance. In this context, cuproptosis, novel copper-induced mitochondria-respiratory-dependent death pathway, offers promising avenue radiosensitization. study, an innovative theranostic nanoplatform was designed induce cuproptosis synergy with low-dose therapy (LDRT, i.e., 0.5–2 Gy) treatment situ hepatocellular carcinoma (HCC). This aims reverse hypoxic tumor microenvironment, promoting shift from glycolysis oxidative phosphorylation (OXPHOS), thereby enhancing sensitivity cuproptosis. Concurrently, Fenton-like reaction ensures sustained supply copper depletion glutathione (GSH), inducing disrupting mitochondrial function, interrupting supply. strategy effectively overcomes radioresistance enhances against tumors. conclusion, study elucidates intricate interactions among hypoxia reversal, metabolic reprogramming, radiosensitization, particularly context treating carcinoma, providing paradigm radiotherapy.
Language: Английский
Citations
1
Materials Today, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 1, 2024
Language: Английский
Citations
0